HUBUNGAN ANTARA DERAJAT PENYAKIT GINJAL KRONIK DENGAN NILAI AGREGASI TROMBOSIT DI RSUP PROF. DR. R. D. KANDOU MANADO

Authors

  • Melti Tandi Universitas Sam Ratulangi
  • Arthur Mongan Universitas Sam Ratulangi
  • Firginia Manoppo Universitas Sam Ratulangi

DOI:

https://doi.org/10.35790/ebm.v2i2.5076

Abstract

Abstract: Chronic kidney disease has got a lot of attention and more widely studied despite reached end stage renal failure, patients still live a long life witha fairly good quality of life although the prevalence is increases throughout the year. one of the circumstances in chronic kidney disease is uremia which is a clinical and laboratory syndrome that occurs inorgans. In uremia interference with platelet function, the production ofprostacyclinin blood vesselswould increase, and excessurea levels in blood would be a potential vasodilator and platelet aggregation antagonist. Methods: An analytic observational cross-sectional study. Samples were patients that diagnosed with chronic kidney disease at the Hospital Clinic of Nephrology-Hypertension Prof. Dr.R. D.Kandou Manado in December toFebruary 2014. Criteria included were patients  <80 years old and has been diagnosed with chronic kidney disease in this case had done a physical examination and investigations by doctors, using medical record of urea-creatinine and also a complete blood countand platelet aggregation in Prokita Laboratory Manado. Forstatistical analysisusedShapiro-Wilk testalsoPearsonCorrelationstest. Result: There were 20 patients with chronic kidney disease sampled in this study. It was found that there is a relationship between of urea-creatinine and aggregation results in trace ADP5(P=0.004) while the value ADP10 no significant correlation(P =0.399). Conclusion: In chronic kidney disease patients, urea-creatininewiththe value of platelet aggregation intrace ADP5had a relation ship while intrace ADP10 had not a relationship.

Keywords: Chronic kidney disease, platelet aggregation.

Author Biographies

Melti Tandi, Universitas Sam Ratulangi

Kandidat Skripsi FK Unsrat

Arthur Mongan, Universitas Sam Ratulangi

Bagian Patologi Klinik FK Unsrat

Firginia Manoppo, Universitas Sam Ratulangi

Bagian Patologi Klinik FK Unsrat

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