Hubungan Kadar Hemoglobin dengan Laju Filtrasi Glomerulus pada Pasien Penyakit Ginjal Kronik Stadium 3 dan 4 Di RSUP Prof. Dr. R. D. Kandou Manado Periode Januari 2017 - Desember 2018
DOI:
https://doi.org/10.35790/ecl.v8i1.27190Abstract
Abstract: Chronic kidney disease (CKD) is defined as kidney damage which occured more than 3 months, with structural or functional abnormalities such as decreasing of glomerular filtration rate (GFR) <60ml/min/1,73m2. This kidney damage will certainly disrupt one of the kidney’s functions as a producer of erythropoietin hormone which plays a role in the process of erythropoiesis. This is related to the hemoglobin levels in the erythocytes themselves. This study was aimed to determine the relationship between Hb level and GFR in patients with stage 3 and 4 CKD at Prof. Dr. R. D. Kandou Hospital Manado. This was an analytical and retrospective study with a cross-sectional design using medical record of patient with stage 3 and 4 CKD at Prof. Dr. R. D. Kandou Hospital from January 2017 to December 2018 as secondary data. The results showed that there were 50 patients with stage 3 and 4 CKD who met the inclusion criteria of 57 existing patients. The Pearson correlation test obtained a p-value of 0.023 and an r value of 0.32 for the relationship between Hb level and GFR. In conclusion, there was a significant relationship between Hb level and GFR in patients with stage 3 and 4 CKD at Prof. Dr. R. D. Kandou Manado from January 2017 to December 2018.
Keywords: CKD, eGFR, hemoglobin level
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Abstrak: Penyakit ginjal kronik (PGK) ditandai dengan adanya kerusakan ginjal yang terjadi lebih dari 3 bulan, berupa kelainan struktural atau fungsional seperti menurunnya laju filtrasi glomeurulus (LFG) <60ml/menit/1,73m2. Kerusakan ginjal pada PGK akan mengganggu fungsi ginjal sebagai penghasil hormon eritropoietin yang berperan dalam eritropoiesis yang berhubungan dengan kadar hemoglobin (Hb) dalam eritrosit. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar Hb dan LFG pada pasien PGK stadium 3 dan 4 di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah analitik retrospektif dengan desain potong lintang menggunakan catatan rekam medik pasien PGK stadium 3 dan 4 di RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2017-Desember 2018 sebagai data sekunder. Hasil penelitian mendapatkan 50 pasien PGK stadium 3 dan 4 yang memenuhi kriteria inklusi dari 57 pasien yang ada. Hasil uji korelasi Pearson mendapatkan nilai p=0,023 dan r=0,320 untuk hubungan antara kadar Hb dengan LFG. Simpulan penelitian ini ialah terdapat hubungan bermakna antara kadar Hb dengan LFG pada pasien PGK stadium 3 dan 4 di RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2017-Desember 2018.
Kata kunci: PGK, LFG, kadar hemoglobin
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