Uji efektivitas ekstrak daun sendok (Plantago major L.) terhadap waktu perdarahan pada tikus Wistar jantan (Rattus norvegicus)

Authors

  • Abedneju R. Kainde
  • Damajanty H.C. Pangemanan
  • Bernart S.P. Hutagalung

DOI:

https://doi.org/10.35790/eg.4.2.2016.14221

Abstract

Abstract: Herbal plant is often used to treat any kind of disease. There are many kinds of plants in Minahasa used as traditional medicine, inter alia daun sendok (Plantago major L.). Daun sendok is often used to treat bleeding. This study was aimed to obtain the effectiveness of daun sendok extract on bleeding time in male Wistar rats. This was a true experimental study with a posttest only group design. This study was conducted at the Laboratory of Pharmacology Faculty of Medicine University of Sam Ratulangi. Total samples were 14 rats divided into 2 groups: control group and treatment group. Wounds of 2 mm depth were perfomed on the rat tails of the treatment group followed by application of daun sendok extract. The results showed that the average bleeding time of the control group was 51.87 seconds meanwhile of the treatment group was 29.67 seconds. The unpaired t-test between the two groups showed a p value of 0.000. Conclusion: Daun sendok (Plantago major L.) extract could reduce the bleeding time in male Wistar rats.

Keywords: bleeding time, daun sendok, Wistar rat

 

Abstrak: Tanaman obat seringkali digunakan untuk mengobati berbagai macam jenis penyakit. Di wilayah Minahasa terdapat banyak jenis tanaman yang digunakan sebagai obat tradisional, salah satunya ialah daun sendok (Plantago major L.) yang seringkali digunakan untuk mengobati perdarahan. Penelitian ini berrtujuan untuk mengetahui efektivitas ekstrak daun sendok terhadap waktu perdarahan tikus Wistar jantan. Jenis penelitian ialah true experimental dengan post test only control group design yang dilakukan di Laboratorium Farmakologi Fakultas Kedokteran Unsrat dengan total sampel berjumlah 14 ekor tikus Wistar yang dibagi menjadi 2 kelompok yaitu: kelompok kontrol dan kelompok perlakuan menggunakan ekstrak daun sendok. Pada kelompok uji diaplikasikan ekstrak daun sendok setelah dilakukan perlukaan di bagian ekor tikus sedalam 2 mm. Hasil penelitian memperlihatkan rerata waktu perdarahan pada kelompok kontrol ialah 51,87 detik sedangkan pada kelompok perlakuan 29,67 detik. hasil uji t tidak berpasangan antara kedua kelompok mendapatkan nilai p=0,000. Simpulan: Ekstrak daun sendok (Plantago major L.) efektif dalam memperpendek waktu perdarahan pada tikus Wistar.

Kata kunci: waktu perdarahan, daun sendok, tikus Wistar

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Published

2016-12-03

How to Cite

Kainde, A. R., Pangemanan, D. H., & Hutagalung, B. S. (2016). Uji efektivitas ekstrak daun sendok (Plantago major L.) terhadap waktu perdarahan pada tikus Wistar jantan (Rattus norvegicus). E-GiGi, 4(2). https://doi.org/10.35790/eg.4.2.2016.14221

Issue

Vol. 4 No. 2 (2016): e-GiGi

Section

Articles

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