UJI DAYA HAMBAT EKSTRAK DAUN DURIAN (Durio zybethinus) TERHADAP PERTUMBUHAN Candida albicans SECARA IN VITRO

Authors

  • Fryano Kandoli

DOI:

https://doi.org/10.35799/pha.5.2016.11223

Abstract

UJI DAYA HAMBAT EKSTRAK DAUN DURIAN

(Durio zybethinus) TERHADAP PERTUMBUHAN

Candida albicans SECARA IN VITRO

Fryano Kandoli1),  Jimmy Abijulu2),  Michael Leman1)

1)Program Studi Kedokteran Gigi Fakultas Kedokteran UNSRAT

2)Jurusan Kimia FMIPA UNSRAT

ABSTRACTS

Candidiasis is fungi infection that common found in dentistry practice. The cause is Candida where seventy percent of  Candida species that infecting is Candida albicans. Durian (Durio zybethinus) is original tropical fruit from Indonesia that enriched with many benefits. Durian leaf contains Saponin and Flavanoid compound that can be used as antifungal agent.  The purpose of this research is to find out the effectiveness of durian leaves against Candida albicans. This research is experimental research with Post test only control group design plan. The method in this antifungal test is Kirbybauer modification method using Paper disk. The concentration of durian leaf used in this research is 100%, positive control Ketokonazole, and aquades as negative control. The Candida albicans are taken from the fungus storage in Chemistry laboratory of Mathematics and Science Faculty of Sam Ratulangi University Manado.The result of this research showed that the extract of durian leaf contains antifungal activity from the inhibition zone that formed around the paper disk contained durian leaf’s extract. This research conclude that durian leaf extract has antifungal activity in inhibiting Candida albicans’s growth as the main cause of Candidiasis.

Key words: Durian leaf (Durio zybethinus), Candida albicans, antifungi

ABSTRAK

 

Kandidiasis merupakan infeksi jamur yang sering dijumpai dalam praktek kedokteran gigi.Penyebabnya adalah jamur Candida dimana sekitar tujuh puluh persen  spesies Candida yang menginfeksi adalah Candida albicans. Durian (Durio zybethinus) merupakan tanaman buah tropis asli Indonesia yang kaya akan beragam  manfaat. Daun durian memiliki senyawa Saponin dan Flavanoid yang memiliki efek antijamur. Tujuan penelitian ini untuk meneliti efektivitas ekstrak daun durian dalam menghambat pertumbuhan jamur Candida albicans. Penelitian ini merupakan penelitian eksperimental dengan rancangan penelitian Post test only control group design. Metode yang digunakan sebagai uji antijamur adalah metode modifikasi Kirbybauer menggunakan Paper Disk. Konsentrasi ekstrak daun durian yang dipakai dalam penelitian ini yaitu 100%, kontrol positif Ketoconazole, serta kontrol negatif menggunakan aquades.  Jamur Candida albicans diambil dari stok jamur Laboratorium Kimia Fakultas MIPA Universitas Sam Ratulangi Manado. Hasil penelitian menunjukan bahwa ekstrak daun durian mempunyai efek anti jamur yang ditunjukan dengan terbentuknya daerah zona hambat di sekitar paper disk yang diberi ekstrak daun durian. Dari penelitian ini dapat disimpulkan bahwa ekstrak daun durian memiliki efek antijamur dalam menghambat pertumbuhan Candida albicans sebagai jamur penyebab Kandidiasis.

 

Kata kunci: Daun durian (Durio zybethinus), Candida albicans, antijamur

 

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Published

2016-02-09

How to Cite

Kandoli, F. (2016). UJI DAYA HAMBAT EKSTRAK DAUN DURIAN (Durio zybethinus) TERHADAP PERTUMBUHAN Candida albicans SECARA IN VITRO. PHARMACON, 5(1). https://doi.org/10.35799/pha.5.2016.11223

Issue

Vol. 5 No. 1 (2016): Pharmacon

Section

Articles

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