6. FORMULASI DAN UJI EFEKTIVITAS SEDIAAN SIRUP EKSTRAK ETANOL DAUN WARU (Hibiscus tiliaceus L.) SEBAGAI ANTIPIRETIK TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI DENGAN VAKSIN DPT

Authors

  • Mersi Molantong

DOI:

https://doi.org/10.35799/pha.3.2014.6045

Abstract

Formulasi dan Uji Efektivitas Sediaan Sirup Ekstrak Etanol Daun Waru (Hibiscus tiliaceus L.) Sebagai Antipiretik Terhadap Tikus Putih Jantan Galur Wistar yang Diinduksi dengan Vaksin DPT

Mersi Molantong, Fatimawali, Hamidah Sri Supriati

Program Studi Farmasi, FMIPA UNSRAT Manado

 

ABSTRACT

Waru leaves (Hibiscus tiliaceus L.) are used empirically by people to treat fever. This research aims to test the stability of the ethanol extract syrup of Waru leaves and its antipyretic effect on white male galur wistar rats after the fever was induced with DPT vaccine. Waru leaves ethanol extract syrup is made in three variations of the concentration of the active substance, they are 5%, 10%, 15% and stability test. The next test of the antipyretic effect is done by measuring animals rectal temperature using a digital thermometer. Result of stability testing on ethanol extract syrup of Waru leaves was homogenous with no precipitate is obtained that has bitter taste, the color is yellow with brown, as well as the characteristic of the smell, has a pH of 5-5,5. In testing antipyretic, ethanol extract syrup of Waru leaves concentration of 10% showed antipyretic effects while ethanol extract syrup of Waru leaves concentration of 5% and 15% did not. The conclusion of this research is that ethanol extract syrup of Waru leaves has good stability which is seen from homogeneity, organoleptic, and pH itself. Furthermore the antipyretic effects are shown by ethanol extract syrup of Waru leaves concentration of 10%, while concentration 5% and 15% did not.

Key words: Antipyretic, Hibiscus tiliaceus L., Syrup

ABSTRAK

Daun Waru (Hibiscus tiliaceus L.) digunakan secara empiris oleh masyarakat untuk mengobati demam. Penelitian ini bertujuan untuk menguji stabilitas sirup ekstrak etanol daun Waru dan efek antipiretiknya terhadap tikus putih jantan galur wistar setelah diinduksi dengan vaksin DPT. Sirup ekstrak etanol daun Waru dibuat dalam 3 variasi konsentrasi zat aktif yaitu 5%, 10%, 15% dan diuji Stabilitasnya. Selanjutnya dilakukan pengujian efek antipiretik dengan mengukur suhu rektal hewan uji menggunakan termometer digital. Hasil pengujian stabilitas sirup ekstrak etanol daun Waru ialah homogen dengan tidak diperolehnya endapan, memiliki rasa yang pahit, berwarna kuning kecoklatan, serta berbau khas, memiliki pH 5-5,5. Pada pengujian antipiretik, sirup ekstrak etanol daun Waru konsentrasi 10% menunjukan efek antipiretik sedangkan konsentrasi 5% dan 15% tidak memiliki efek antipiretik. Kesimpulan penelitian ini ialah sirup ekstrak etanol daun Waru memiliki stabilitas yang baik dilihat dari uji homogenitas, organoleptik, dan pH sediaan. Selanjutnya efek antipiretik ditunjukan oleh sirup ekstrak etanol daun Waru konsentrasi 10%, sedangkan konsentrasi 5% dan 15% tidak menunjukan efek antipiretik.

 

Kata kunci : Antipiretik, Hibiscus tiliaceus L., Sirup

 

 

 

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Published

2014-11-04

How to Cite

Molantong, M. (2014). 6. FORMULASI DAN UJI EFEKTIVITAS SEDIAAN SIRUP EKSTRAK ETANOL DAUN WARU (Hibiscus tiliaceus L.) SEBAGAI ANTIPIRETIK TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI DENGAN VAKSIN DPT. PHARMACON, 3(4). https://doi.org/10.35799/pha.3.2014.6045

Issue

Vol. 3 No. 4 (2014): pharmacon

Section

Articles

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