Hubungan Lingkar Pinggang, Homeostasis Model Assessment of Insulin Resistance, dan Prostaglandin-I2 dengan Test Agregasi Trombosit pada Subyek Obesitas Sentral

Abstract

Abstract: Overweight and obese are global health problems and tend to increase in Indonesia. Central obesity is associated with inflammation, insulin resistance, and increased reactive oxidative stress. Insulin resistance can cause a decrease in prostaglandin I₂ (PGI₂) and nitric oxide (NO) levels, and an increase in platelet aggregation. Its effect in platelet aggregation may increase thrombus formation in blood vessels. This study was aimed to determine the relationship between waist circumference (WC) with HOMA-IR, PGI₂ and platelet aggregation test (PAT) in central obese subjects. This was an observational and analytical correlational study with a cross-sectional design conducted at Prof. dr. R. D. Kandou Hospital, Manado. Samples were 33 central obese subjects, 19 were male and 14 were female. Insulin resistance was measured by using HOMA- IR, urine PGI₂, and PAT. The Spearmann and Pearson correlation test showed a positive correlation between WC and HOMA-IR (r=0.366, p=0.036). There was a negative correlation but not significant between WC and PGI₂ (r=-0.169, p=0.347); between WC and PAT (r=0.094, p=0.603); between HOMA-IR and PGI₂ (r=-0.218, p=0.223); and between HOMA-IR and PAT (r=0.080, p=0.658). In conclusion, in central obese people, there  is a relationship between WC and HOMA-IR, but there is no relationship between WC, PGI₂, and PAT.

Keywords: central obesity, HOMA-IR, prostaglandin-I2, platelet aggregation test

Abstrak: Berat badan berlebih atau obesitas merupakan masalah kesehatan global dan terus meningkat di Indonesia. Pada obesitas sentral terjadi inflamasi, resistensi insulin, dan mening-katnya reaktif oksidatif stress. Resistensi insulin mampu menyebabkan penurunan kadar prostaglandin I₂ (PGI₂) dan nitrik oksida (NO). Penurunan kadar PGI₂ dapat menyebabkan peningkatan agregasi trombosit yang selanjutnya meningkatkan kemungkinan terjadinya trombus dalam pembuluh darah. Penelitian ini bertujuan untuk mengetahui hubungan antara lingkar pinggang dengan HOMA-IR, PGI₂, dan test agregasi trombosit (TAT) pada subyek obes sentral. Jenis penelitian ialah observasional analitik bentuk korelasional dengan desain potong lintang. Penelitian dilakukan di RSUP Prof. dr. R. D. Kandou Manado. Total sampel 33  subyek dengan obesitas sentral, 19 laki-laki dan 14 perempuan. Pengukuran resistensi insulin menggunakan HOMA-IR, PGI₂ urin, dan TAT. Uji korelasi Spearmann dan Pearson. mendapatkan korelasi positif antara LP dengan HOMA-IR (r=0,366; p=0,036). Terdapat korelasi negatif tidak bermakna pada hubungan antara LP dengan PGI₂ (r=-0,169; p=0,347); hubungan antara LP dengan TAT (r=0,094; p=0,603); hubungan antara HOMA-IR dengan PGI₂ (r=-0,218;p=0,223); dan hubungan antara HOMA-IR dengan TAT (r=0,080; p=0,658). Simpulan penelitian ini ialah pada subyek obes sentral terdapat hubungan antara lingkar pinggang dengan HOMA-IR, tetapi tidak terdapat hubungan antara lingkar pinggang dengan PGI₂ dan TAT.  

Kata kunci: obesitas sentral, HOMA-IR, prostaglandin-I₂, tes agregasi trombosit