Gambaran hasil pemeriksaan fungsi hati pada anak dengan infeksi dengue periode Januari 2011-Oktober 2016 di RSUP Prof. Dr. R. D. Kandou Manado
DOI:
https://doi.org/10.35790/ecl.v4i2.14476Abstract
Abstract : Dengue infection still one of the global health problem. Hepatic dysfunction is common in dengue infection and the spectrum of liver dysfunction in children with dengue infection is wide and has been associated with disease severity. Hepatic dysfunction can be measured with aminotransferase levels. Significant rise of aminotransferase level helps in recognition of severe form of dengue infection. This study aimed to obtain the profile of aminotransferase levels of children diagnosed with dengue infection. This was a descriptive retrospective study using medical record data of patients in Pediatrics Department Prof. Dr. R.D. Kandou Hospital Manado. There were 432 patients with dengue infection during the period 2011-2016. Patients performed liver function test were 222 patients, however, only 183 patients that meet the inclusion criteria. All cases were grouped into Dengue Fever (DF), Dengue hemorrhagic fever (DHF) and Dengue shock syndrome (DSS) according to WHO criteria. Most patient diagnosed with DSS. Aminotransferase levels rise more significant in DSS and DHF group compared to DF group. AST was elevated more than ALT.
Keywords: dengue infection, children, liver function, AST, ALT
Â
Abstrak: Infeksi dengue masih merupakan masalah kesehatan global. Disfungsi hati umum ditemukan pada infeksi dengue dan spektrum disfungsi hati pada anak dengan infeksi dengue luas dan berkaitan dengan keparahan penyakit. Disfungsi hati dapat diukur dengan kadar aminotransferase. Peningkatan signifikan kadar enzim transaminase dapat membantu mengenali infeksi berat virus dengue. Penelitian ini bertujuan untuk mengetahui gambaran hasil pemeriksaan fungsi hati pada anak dengan infeksi dengue. Penelitian ini adalah penelitian deskritif retrospektif dengan menggunakan data rekam medik pasien di Bagian Ilmu Kesehatan Anak RSUP Prof. Dr. R. D. Kandou Manado. Sebanyak 432 pasien infeksi virus dengue periode 2011-2016 dan yang diperiksa fungsi hati sebanyak 222 pasien, namun hanya 183 pasien yang memenuhi kriteri inklusi. Semua kasus dikelompokkan menjadi Demam Dengue (DD), Demam berdarah dengue (DBD), dan Sindroma Syok Dengue (SSD). Pasien terbanyak adalah pasien SSD. Peningkatan kadar enzim aminotransferase lebih signifikan pada kelompok SSD dan DBD dibandingkan DD. SGOT meningkat lebih tinggi dibandingkan SGPT.
Kata kunci: infeksi dengue, anak, fungsi hati, AST, ALT
Downloads
How to Cite
Issue
Section
License
COPYRIGHT
Authors who publish with this journal agree to the following terms:
Authors hold their copyright and grant this journal the privilege of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that permits others to impart the work with an acknowledgment of the work's origin and initial publication by this journal.
Authors can enter into separate or additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (for example, post it to an institutional repository or publish it in a book), with an acknowledgment of its underlying publication in this journal.
Authors are permitted and encouraged to post their work online (for example, in institutional repositories or on their website) as it can lead to productive exchanges, as well as earlier and greater citation of the published work (See The Effect of Open Access).
