Profil Penyakit Jantung Bawaan pada Neonatus yang Dirawat di Ruang Perawatan Intensif Neonatal RSUP Prof. Dr. R. D. Kandou Periode 2022-2024
DOI:
https://doi.org/10.35790/9twm1e49Keywords:
penyakit jantung bawaan; neonatus; tipe penyakit; asianotik; sianotikAbstract
Abstract: Congenital heart disease (CHD) is the most common congenital anomaly in neonates with the highest mortality rate in the first week of life. This study aimed to determine the profile of CHD in neonates admitted to the Neonatal Intensive Care Unit of Prof. Dr. R. D. Kandou General Hospital, Manado, during 2022-2024. This was a retrospective descriptive study with a cross-sectional approach using medical records of neonates with CHD. The results showed that there were 762 CHD cases with increasing incidence of 9.68% from 2022 to 2023, and of 23.62% from 2023 to 2024. Most patients were male (59.58%), born by caesarean section (71%), referred (59.32%), premature (50%), from mothers aged 25–29 years (23.10%), and from singleton pregnancies (93.83%). Acyanotic CHD dominated (98.23% in single defects) with ASD as the most common type (76.98%). Mean age at diagnosis was 5 days, length of stay 15 days, with mortality rate of 35.30%. CMV infection and UDT were the most common associated anomalies. In conclusion, there is a significant increase in CHD incidence among neonates with ASD as the dominant type, relatively early diagnosis, but still high mortality.
Keywords: congenital heart disease; neonates; types of disease; acyanotic; cyanotic
Abstrak: Penyakit jantung bawaan (PJB) merupakan kelainan kongenital tersering pada neonatus dengan tingkat mortalitas tertinggi pada minggu pertama kehidupan. Penelitiann ini bertujuan untuk mengetahui profil PJB pada neonatus yang dirawat di Ruang Perawatan Intensif Neonatal RSUP Prof. Dr. R. D. Kandou Manado periode 2022-2024. Jenis penelitian ialah deskriptif retrospektif dengan desain potong lintang menggunakan data rekam medis neonatus dengan PJB. Hasil penelitian mendapatkan 762 kasus PJB dengan peningkatan insidensi sebesar 9,68% dari tahun 2022 ke 2023, dan sebesar 23,62% dari tahun 2023 ke 2024. Mayoritas pasien ialah laki-laki (59,58%), lahir secara sectio cesarea (71%), rujukan (59,32%), prematur (50%), dari kelompok ibu berusia 25 – 29 tahun (23,10%), dan dari kehamilan tunggal (93,83%). Jenis PJB asianotik mendominasi (98,23% pada single defect) dengan ASD sebagai jenis tersering (76,98%). Rerata usia diagnosis 5 hari, lama rawat inap 15 hari, dengan tingkat mortalitas 35,30%. Infeksi CMV dan UDT merupakan kelainan penyerta tersering. Simpulan penelitian ini ialah terdapat peningkatan signifikan kejadian PJB pada neonatus dengan ASD sebagai jenis dominan, dengan diagnosis relatif dini, namun mortalitas masih tinggi.
Kata kunci: penyakit jantung bawaan; neonates; tipe penyakit; asianotik; sianotik
References
1. Meng X, Song M, Zhang K, Lu W, Li Y, Zhang C, et al. Congenital heart disease: types, pathophysiology, diagnosis, and treatment options. MedComm. 2024;5(7):1-41. Doi: https://doi.org/10.1002/pd.6617
2. Xu J, Li Q, Deng L, Xiong J, Cheng Z, Ye C. Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021. Front Cardiovasc Med. 2025;12:1-12. Doi: https://doi.org/10.3389/fcvm.2025.1522644.
3. Marwali EM, Purnama Y, Roebiono PS. Modalitas Deteksi Dini Penyakit Jantung Bawaan di Pelayanan Kesehatan Primer. J Indonesian Med Assoc. 2021;71(2):100–9. Available from: https://mki-ojs.idionline.org/jurnal/article/download/241/197/
4. Kementerian Kesehatan RI. Survei Kesehatan Indonesia (SKI) 2023 Dalam Angka. Jakarta: Kemenkes; 2023.
5. Khan A. Neonatal diseases & disorders: a comprehensive overview. J Neonatal Stud. 2023;6(4):23–5. Doi: https://doi.org/10.37532/jns.2023.6(4).92-95
6. Ali N, Donofrio MT. Delivery room and early postnatal management of neonates with congenital heart disease. Prenat Diagn. 2024;44(8):915–24. Doi: https://doi.org/10.1002/pd.6617
7. Bachnas MA, Andonotopo W, Pribadi A, Dewantiningrum J, Pramono MBA, Sulistyowati S, et al. Fetal cardiac diagnostics in Indonesia: a study of screening and echocardiography. J Perinat Med. 2025;53(5):561–75. Doi: https://doi.org/10.1515/jpm-2025-0037.
8. Manopo BR, Kaunang ED, Umboh A. Gambaran penyakit jantung bawaan di Neonatal Intensive Care Unit RSUP Prof. Dr. R. D. Kandou Manado periode 2013-2017. e-CliniC. 2018;6(2):87-93. Doi: https://doi.org/10.35790/ecl.v6i2.22124
9. Cabral GHB, Guerra JVN, Pedrosa KU, Conrado PLM, Fonseca JHDA, Luna VLM, et al. Congenital heart disease: epidemiological profile of live births, geographical distribution and temporal trends in Brazil from 2012 to 2022. BMC Cardiovasc Disord. 2025;25(1):1-11. Doi: https://doi.org/10.1186/s12872-025-05079-8
10. Cavilha LG, Dalri MCF, Da Rocha FR, Hebeda CB. Outcome and prevalence of congenital heart diseases in neonates at a tertiary hospital in the State of Santa Catarina. Ann Pediatr Child Health. 2023;11(5):1–6. Doi: https://doi.org/10.47739/2373-9312/1318
11. Nastiti AA, Triharini M, Santika NKA, Dewi YS, Barnawi EA, Arifin H. Determinants of caesarean section delivery: a nationwide study in Indonesia. Br J Midwifery. 2022;30(5):282–9. Doi: https://doi.org/10.12968/bjom.2022.30.5.282
12. Mannan MA, Afroze S, Ruba IJ, Sultana T, Rahman T, Shaon SNU, et al. Pattern of congenital heart disease with its outcome among 100 newborns admitted in a tertiary care hospital in Dhaka, Bangladesh. J Pediatr Neonatal. 2022;4(3):1-5. Doi: https://doi.org/10.33425/2689-1085.1050
13. Badan Pusat Statistik Indonesia. Angka Kelahiran menurut Kelompok Umur Ibu (ASFR) Menurut Provinsi 1971-2020. Jakarta: BPS; 2020.
14. Zaidi F, Iqbal M, Zafar F, Khan L, Khalid A, Lawa S. Prevalence and risk factors of congenital heart disease in patients admitted in NICU. Pak J Health Sci. 2025;6(4):70–5. Doi: https://doi.org/10.54393/pjhs.v6i4.2884
15. Gerede A, Orgianelis I, Stavros S, Potiris A, Drakaki E, Tsimpoukis I, et al. Unmasking the placenta–heart axis: a comprehensive review of placental abnormalities in congenital heart disease. Diagnostics. 2025;15(17):2159. Doi: https://doi.org/10.3390/diagnostics15172159
16. Alabdali AK, Softah EM, Alansari AS, Turkistani SA, Yagmoour AT, Alosaimi FG, et al. Neonatal congenital heart defects: prevalence, maternal factors and survival outcomes at a tertiary hospital in Jeddah. J Adv Trends Med Res. 2025;2(1):76–81. Doi: https://doi.org/10.4103/ATMR.ATMR_26_25
17. Yan H, Zhai B, Feng R, Wang P, Zhang Y, Wang Y, et al. Prevalence of congenital heart disease in Chinese children with different birth weights and its relationship to the neonatal birth weight. Front Pediatr. 2022;10:1-13. Doi: https://doi.org/10.3389/fped.2022.828300
18. Akhter K, Malek A, Ikram S, Sultana R, Hamid MA, Afroz F. Common pattern of congenital heart disease with outcome in sick term and preterm neonates admitted in NICU. The Planet. 2024;8(1):43–7. Available from: https://bdjournals.org/planet/article/view/614
19. Hasan AA, Abu Lehyah NAA, Al Tarawneh MK, Abbad MY, Fraijat AG, Al-Jammal RA, et al. Incidence and types of congenital heart disease at a referral hospital in Jordan. Front Pediatr. 2023;11:1-6. Doi: https://doi.org/10.3389/fped.2023.1261130.
20. Singh RK, Jain PK, Dhakar JS, Shrivastava M, Gohiya P. Clinical profile and pattern of congenital heart disease in neonates. SSR Inst Int J Life Sci. 2024;10(3):5497–503. Doi: https://doi.org/10.21276/SSR-IIJLS.2024.10.3.1
21. Thirumurugan P, Kumaran S, Prakabar D. Study of congenital heart disease in neonates. Int J Acad Med Pharm. 2023;5(2):499–503. Doi: https://doi.org/10.47009/jamp.2023.5.2.105
22. Singh Y, Tissot C. Echocardiographic evaluation of transitional circulation for the neonatologists. Front Pediatr. 2020;8. Doi: https://doi.org/10.3389/fped.2018.00140
23. Khasawneh W, Hakim F, Abu Ras O, Hejazi Y, Abu-Aqoulah A. Incidence and patterns of congenital heart disease among Jordanian infants. Front Pediatr. 2020;8:1-6. Doi: https://doi.org/10.3389/fped.2020.00219
24. Jamil A, Ikram F, Nawaz R, Hussain M, Naz S, Ateeq S. Congenital heart disease among neonates in a neonatal unit of a tertiary care hospital. Pak Armed Forces Med J. 2024;74(5):1264–7. Doi: https://doi.org/10.51253/pafmj.v74i5.7021
25. Parvar SY, Ghaderpanah R, Naghshzan A. Prevalence of congenital heart disease according to the echocardiography findings in 8145 neonates, multicenter study in southern Iran. Health Sci Rep. 2023;6(4):1-8. Doi: https://doi.org/10.1002/hsr2.1178
26. Akaffou-Gbery AE, Azagoh-Kouadio R, Mobio ALL, Atteby JJY, Anoh SMJN, Yao KR. Epidemiological, clinical progress aspects of congenital heart disease with neonatal revelation at the Mother-Child Hospital of Bingerville. Open J Pediatr. 2024;14(01):89–100. Doi: https://doi.org/10.4236/ojped.2024.141010.
27. Dewi PDR, Gunawijaya E, Yanti NPVK. Early versus late diagnosis of critical congenital heart disease at Sanglah Hospital Denpasar, Bali. GSC Adv Res Rev. 2022;11(3):072–6. Doi: https://doi.org/10.30574/gscarr.2022.11.3.0159
28. Bah MNM, Sapian MH, Alias EY. Birth prevalence and late diagnosis of critical congenital heart disease: A population-based study from a middle-income country. Ann Pediatr Cardiol. 2020;13(4):320. Doi: https://doi.org/10.4103/apc.APC_35_20
29. Dawson AL, Cassell CH, Riehle-Colarusso T, Grosse SD, Tanner JP, Kirby RS, et al. Factors associated with late detection of critical congenital heart disease in newborns. Pediatrics. 2013;132(3):e604–11. Doi: https://doi.org/10.1542/peds.2013-1002
30. Wang T, Li Q, Chen L, Ni B, Sheng X, Huang P, et al. Maternal viral infection in early pregnancy and risk of congenital heart disease in offspring. Clin Epidemiol. 2022;14:71–82. Doi: https://doi.org/10.2147/CLEP.S338870
31. Huang X, Gao Y, Chen W, Sheng W, Huang G. Noncardiac anomalies in children with congenital heart disease. Front Cardiovasc Med. 2023;10:1293210. Doi: https://doi.org/10.3389/fcvm.2023.1293210
32. Holmboe SA, Beck AL, Andersson AM, Main KM, Jørgensen N, Skakkebæk NE, et al. The epidemiology of cryptorchidism and potential risk factors, including endocrine disrupting chemicals. Front Endocrinol. 2024;15:1-8. Doi: https://doi.org/10.3389/fendo.2024.1343887
33. Radvar M, Gol AZ, Fakour Z, Farhadi E. Epidemiology of clinical findings and outcome in neonates with congenital heart disease. Health Sci Monit. 2022;1(2):74–80. Doi: https://doi.org/10.52547/hsm.1.2.74.
34. Aliku T, Beaton A, Lubega S, Dewyer A, Scheel A, Kamarembo J, et al. Profile of congenital heart disease and access to definitive care among children seen at Gulu Regional Referral Hospital in Northern Uganda. J Congenit Cardiol. 2021;5(9):1-6. Doi: https://doi.org/10.1186/s40949-021-00064-0
35. Ayfokru A, Shewasinad S, Ahmed F, Tefera M, Nigussie G, Getaneh M, et al. Incidence and predictors of mortality among neonates admitted for congenital heart disease in public comprehensives specialized hospitals, Amhara Region, Ethiopia 2023. BMC Pediatrics. 2023;24(1):1-11. Doi: https://doi.org/10.1186/s12887-024-05023-3
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Shereen R. L. Rompis, David S. Waworuntu, Rocky Wilar

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
COPYRIGHT
Authors who publish with this journal agree to the following terms:
Authors hold their copyright and grant this journal the privilege of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that permits others to impart the work with an acknowledgment of the work's origin and initial publication by this journal.
Authors can enter into separate or additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (for example, post it to an institutional repository or publish it in a book), with an acknowledgment of its underlying publication in this journal.
Authors are permitted and encouraged to post their work online (for example, in institutional repositories or on their website) as it can lead to productive exchanges, as well as earlier and greater citation of the published work (See The Effect of Open Access).




















