Effects of Amino Acid Infusion on Amniotic Fluid Volume and Perinatal Outcomes in Oligohydramnios Patients: An Evidence-Based Case Report
DOI:
https://doi.org/10.35790/yqg6v656Keywords:
amino acid infusion; amniotic fluid index (AFI); oligohydramnios; perinatal outcomeAbstract
Abstract: Oligohydramnios is associated with perinatal morbidity and mortality. Intravenous (IV) amino acid infusion is a proposed management strategy to improve amniotic fluid volume and fetal nutrition. This evidence-based case report evaluates the efficacy of IV amino acid infusion versus standard IV hydration on Amniotic Fluid Index (AFI) and perinatal outcomes. This was a systematic search conducted on PubMed, Scopus, Cochrane, and Google Scholar for randomized controlled trials or semi-experimental studies. Critical appraisal was performed using OCEBM criteria. The results showed that literature screening process yielded three eligible studies, comprising one RCT and two semi-experimental studies. Two of these studies reported a statistically significant increase in AFI among patients in the amino acid infusion group (p<0.001), while one study observed no significant difference compared to standard IV hydration. However, all three studies consistently demonstrated significant clinical improvements in estimated fetal weight gain and the prolongation of gestational age. Additionally, the need for NICU admission and perinatal mortality rates were lower in the amino acid groups. A notable methodological limitation identified across the appraised studies was the absence of reported confidence intervals. In conclusion, intravenous amino acid infusion serves as a potential and effective adjuvant therapy for patients with oligohydramnios. While evidence showing superior AFI improvement remains inconsistent across the studies, the intervention consistently improves fetal weight gain, reduces the risk of preterm birth, and enhances overall perinatal survival rates.
Keywords: amino acid infusion; amniotic fluid index (AFI); oligohydramnios; perinatal outcome
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