Peran Planetary Health Diet dalam Pencegahan Primer Kanker Kolorektal dan Relevansinya terhadap Pola Pangan Indonesia
DOI:
https://doi.org/10.35790/3tar4f42Keywords:
planetary health diet; EAT-Lancet; kanker kolorektal; pencegahan primer; pola pangan IndonesiaAbstract
Abstract: Colorectal cancer is a major health burden in Indonesia. Diet is a modifiable risk factor, including red and processed meat consumption and low fiber intake. This structured narrative review evaluated the role of the planetary health diet in primary prevention of colorectal cancer and its relevance to Indonesian dietary patterns. Literature searches were conducted through July 2026 using PubMed/MEDLINE, ScienceDirect, and SpringerLink, supplemented by backward citation searching and official institutional sources. There were 26 sources included, comprising 19 journal articles and seven official documents. Cohort studies generally reported a lower colorectal cancer risk with greater adherence to the EAT-Lancet diet, whereas recent meta-analyses yielded inconsistent estimates. Potential mechanisms included higher fiber intake and butyrate production and reduced exposure to carcinogenic compounds associated with processed meat and high-temperature cooking. Red meat may still contributed high-quality protein and key micronutrients when consumed in appropriate amounts. In conclusion, the planetary health diet may support colorectal cancer prevention, but its application in Indonesia should consider nutritional adequacy, diversity of protein sources, and local food availability.
Keywords: planetary health diet; EAT-Lancet; colorectal cancer; primary prevention; Indonesian dietary pattern
Abstrak: Kanker kolorektal merupakan salah satu keganasan dengan beban kesehatan yang tinggi di Indonesia. Pola makan merupakan faktor risiko yang dapat dimodifikasi, termasuk konsumsi daging merah dan daging olahan serta rendahnya asupan serat. Tinjauan naratif terstruktur ini bertujuan mengevaluasi peran planetary health diet dalam pencegahan primer kanker kolorektal dan relevansinya terhadap pola pangan Indonesia. Penelusuran dilakukan hingga Juli 2026 melalui PubMed/MEDLINE, ScienceDirect, dan SpringerLink, disertai penelusuran sitasi balik dan sumber institusi resmi. Sebanyak 26 sumber digunakan, terdiri atas 19 artikel jurnal dan tujuh dokumen resmi. Studi kohort menunjukkan kecenderungan risiko kanker kolorektal yang lebih rendah pada kepatuhan EAT-Lancet diet yang lebih tinggi, tetapi hasil meta-analisis terbaru belum sepenuhnya konsisten. Mekanisme potensial meliputi peningkatan asupan serat dan produksi butirat serta berkurangnya paparan senyawa karsinogenik dari daging olahan dan pemasakan suhu tinggi. Daging merah tetap dapat berkontribusi sebagai sumber protein dan mikronutrien bila dikonsumsi dalam jumlah yang sesuai. Simpulan penelitian ini ialah planetary health diet berpotensi mendukung pencegahan kanker kolorektal, tetapi penerapannya di Indonesia perlu disesuaikan dengan kecukupan gizi, keragaman sumber protein, dan pangan lokal.
Kata kunci: planetary health diet; EAT-Lancet; kanker kolorektal; pencegahan primer; pola pangan Indonesia
References
1. Ferlay J, Ervik M, Lam F, Laversanne M, Colombet M, Mery L, et al. Global Cancer Observatory: Cancer Today (version 1.1). Lyon: International Agency for Research on Cancer; 2024 [cited 2026 Jul 30]. Available from: https://gco.iarc.who.int/today
2. Lukman K, Muhammad A, Ghozali M, Nugraha P, Sribudiani Y, Nursabur BM. Epidemiological and clinicopathological characteristics of colorectal cancer patients in tertiary hospital in West Java. Clin Epidemiol Glob Health. 2024 Jul-Aug;28:101688. Doi: https://doi.org/10.1016/j.cegh.2024.101688
3. Miller V, Reedy J, Cudhea F, Zhang J, Shi P, Erndt-Marino J, et al. Global, regional, and national consumption of animal-source foods between 1990 and 2018: findings from the Global Dietary Database. Lancet Planet Health. 2022 Mar;6(3):e243-e256. Doi: https://doi.org/10.1016/S2542-5196(21)00352-1
4. Menteri Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan Republik Indonesia Nomor 41 Tahun 2014 tentang Pedoman Gizi Seimbang [Internet]. Jakarta: Kementerian Kesehatan Republik Indonesia; 2014 [cited 2026 Sep 26]. Berita Negara Republik Indonesia Tahun 2014 Nomor 1110. Available from: https://peraturan.bpk.go.id/Details/119080/permenkes-no-41-tahun-2014
5. Darmawan ES, Kusuma D, Permanasari VY, Amir V, Tjandrarini DH, Dharmayanti I. Beyond the plate: uncovering inequalities in fruit and vegetable intake across Indonesian districts. Nutrients. 2023;15(9):2160. Doi: https://doi.org/10.3390/nu15092160
6. Badan Penelitian dan Pengembangan Kesehatan. Laporan Nasional Riskesdas 2018. Jakarta: Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan; 2019 [cited 2026 Sep 26]. Available from: https://www.badankebijakan.kemkes.go.id/repositori/id/eprint/3514/. ISBN: 978-602-373-118-3.
7. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Red meat and processed meat. Lyon: International Agency for Research on Cancer; 2018 [cited 2026 Sep 26]. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 114. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507971/. PubMed PMID: 29949327.
8. Willett W, Rockstrom J, Loken B, Springmann M, Lang T, Vermeulen S, et al. Food in the anthropocene: the EAT-Lancet Commission on healthy diets from sustainable food systems. Lancet. 2019;393(10170):447-92. Doi: https://doi.org/10.1016/S0140-6736(18)31788-4
9. Bulanda S, Janoszka B. Consumption of thermally processed meat containing carcinogenic compounds (polycyclic aromatic hydrocarbons and heterocyclic aromatic amines) versus a risk of some cancers in humans and the possibility of reducing their formation by natural food additives: a literature review. Int J Environ Res Public Health. 2022;19(8):4781. Doi: https://doi.org/10.3390/ijerph19084781
10. Ungvari Z, Fekete M, Varga P, Lehoczki A, Munkacsy G, Fekete JT, et al. Association between red and processed meat consumption and colorectal cancer risk: a comprehensive meta-analysis of prospective studies. Geroscience. 2025;47(3):5123-40. Doi: https://doi.org/10.1007/s11357-025-01646-1
11. Al-Qadami GH, Secombe KR, Subramaniam CB, Wardill HR, Bowen JM. Gut microbiota-derived short-chain fatty acids: impact on cancer treatment response and toxicities. Microorganisms. 2022;10(10):2048. Doi: https://doi.org/10.3390/microorganisms10102048
12. Mirzaei R, Afaghi A, Babakhani S, Sohrabi MR, Hosseini-Fard SR, Babolhavaeji K, et al. Role of microbiota-derived short-chain fatty acids in cancer development and prevention. Biomed Pharmacother. 2021;139:111619. Doi: https://doi.org/10.1016/j.biopha.2021.111619
13. Zhu R, Wang L, Chen H, Ren J, Wang R, Gong Y, et al. The health and environmental impacts, safety, and affordability of the EAT-Lancet Planetary Health Diet: a multidisciplinary systematic review and meta-analysis. Adv Nutr. 2026;17(7):100666. Doi: https://doi.org/10.1016/j.advnut.2026.100666
14. Li X, Chen J, Sun Z, Ni M, Fu M, Tang Y. Association between EAT-Lancet diet adherence and cancer incidence/mortality: a systematic review and meta-analysis. Front Oncol. 2026;16:1823812. Doi: https://doi.org/10.3389/fonc.2026.1823812
15. Rosendal LB, Bundgaard C, Zhang J, Olsen A, Rostgaard-Hansen AL, Dahm CC, et al. Adherence to the EAT-Lancet diet and risk of colorectal cancer in the general population and among individuals with diabetes: a cohort study. Eur J Nutr. 2026;65(3):90. Doi: https://doi.org/10.1007/s00394-026-03936-6
16. Ren X, Yu C, Peng L, Gu H, Xiao Y, Tang Y, et al. Compliance with the EAT-Lancet diet and risk of colorectal cancer: a prospective cohort study in 98,415 American adults. Front Nutr. 2023;10:1264178. Doi: https://doi.org/10.3389/fnut.2023.1264178
17. Hu FL, Liu JC, Li DR, Xu YL, Liu BQ, Chen X, et al. EAT-Lancet diet pattern, genetic risk, and risk of colorectal cancer: a prospective study from the UK Biobank. Am J Clin Nutr. 2025;121(5):1017-24. Doi: https://doi.org/10.1016/j.ajcnut.2025.02.025
18. Huang L, Li W, Lu Y, Ju Q, Ouyang M. Iron metabolism in colorectal cancer. Front Oncol. 2023;13:1098501. Doi: https://doi.org/10.3389/fonc.2023.1098501
19. National Cancer Institute. Chemicals in meat cooked at high temperatures and cancer risk. Bethesda (MD): National Cancer Institute; 2017 [cited 2026 Aug 5]. Available from: https://www.cancer.gov/about-cancer/causes-prevention/risk/diet/cooked-meats-fact-sheet
20. Zhao H, Yang F, Yang J, Yang S. Multifaceted roles of microbiota-derived deoxycholic acid in gastrointestinal cancers: from barrier disruption to therapeutic implications. Hum Cell. 2025;38(6):176. Doi: https://doi.org/10.1007/s13577-025-01304-w
21. Liu Y, Zhang S, Zhou W, Hu D, Xu H, Ji G. Secondary bile acids and tumorigenesis in colorectal cancer. Front Oncol. 2022;12:813745. Doi: https://doi.org/10.3389/fonc.2022.813745
22. Liu B, Huang Y, Wang X, Liu X, Luo Y, Wang N, et al. Butyrate blocks cell cycle progression in colorectal cancer organoids partially through HDAC2 inhibition. Front Immunol. 2026;17:1788434. Doi: https://doi.org/10.3389/fimmu.2026.1788434
23. Rock CL, Thomson C, Gansler T, Gapstur SM, McCullough ML, Patel AV, et al. American Cancer Society guideline for diet and physical activity for cancer prevention. CA Cancer J Clin. 2020;70(4):245-71. Doi: https://doi.org/10.3322/caac.21591
24. World Cancer Research Fund International. Limit consumption of red and processed meat. London: World Cancer Research Fund International; 2018 [cited 2026 Sep 26]. Available from: https://www.wcrf.org/research-policy/evidence-for-our-recommendations/limit-red-processed-meat/
25. Badan Kebijakan Pembangunan Kesehatan. Survei Kesehatan Indonesia (SKI) 2023 dalam angka. Jakarta: Badan Kebijakan Pembangunan Kesehatan; 2024 [cited 2026 Jul 23]. Available from: https://www.badankebijakan.kemkes.go.id/repositori/id/eprint/5539/
26. Nurhasan M, Ariesta DL, Utami MMH, Fahim M, Aprillyana N, Maulana AM, et al. Dietary transitions in Indonesia: the case of urban, rural, and forested areas. Food Secur. 2024;16(6):1313-31. Doi: https://doi.org/10.1007/s12571-024-01488-3
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Ni Luh Wayan Pani A. Sari, Nurul R. M. Manikam

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
COPYRIGHT
Authors who publish with this journal agree to the following terms:
Authors hold their copyright and grant this journal the privilege of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that permits others to impart the work with an acknowledgment of the work's origin and initial publication by this journal.
Authors can enter into separate or additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (for example, post it to an institutional repository or publish it in a book), with an acknowledgment of its underlying publication in this journal.
Authors are permitted and encouraged to post their work online (for example, in institutional repositories or on their website) as it can lead to productive exchanges, as well as earlier and greater citation of the published work (See The Effect of Open Access).





















