The Potential of African Leaf Extract (Gymnanthemum amygdalinum Del.) as Antihypertensive in Male White Rats
Hypertension is a non-communicable disease that often occurs in the community and causes serious health problems. The number of cases of hypertension that occurs in Indonesia increases the exploration of the use of natural ingredients, one of which is African leaves as a traditional medicine that is developed into herbal medicine and standardized herbal medicine. Flavonoids are known to have the ability to inhibit the activity of the angiotensin-converting enzyme. African leaves are one of the plants that contain flavonoid secondary metabolites that can be obtained by the MAE (Microwave Assisted Extraction) extraction method using 70% ethanol as a solvent. Induction of hypertension was carried out by giving 2% prednisone-NaCl solution for 21 days, the positive control used was the ACEI captopril group with a dose of 0.45 mg/200 g BW and the preparation of African leaf extract was made in 3 doses, namely the dose 100 mg.kg-1 BW, dose II 150 mg.kg-1 BW, and dose III 200 mg.kg-1 BW) given orally. Blood pressure was measured every 7 days using a CODA® non-invasive blood pressure measuring device. The results showed that the African leaf has an antihypertensive effect where the most effective dose in lowering blood pressure is dose III 200 mg.kg-1 BW with a blood pressure reduction time of 14 days.