Gambaran Fungsi Ginjal pada Pasien Sepsis Neonatorum di RSUP. Prof. Dr. R. D. Kandou
Abstract
Abstract: Neonatal sepsis is a systemic response to infection caused by bacterias, virus, fungi, and protozoa within the first 28 days after birth. In neonatal sepsis, inflammation of the entire body occurs in response to infection. If during the aforementioned inflammation process a homeostasis between proinflammatory and anti inflammatory cytokine was not present, a maladaptive inflammatory process will occur which will cause multiple organ dysfunction that most often manifest as acute renal impairment. This study was aimed to identify renal function in neonatal sepsis patients admitted to Prof. Dr. R. D. Kandou Hospital during July 2016 to June 2018. This was a descriptive study with a cross sectional design. Samples were all neonatal sepsis patients that conduct renal function examination using glomerular filtration rate (GFR) as measurement instrument of the research. Out of 405 samples, 75,80% neonatal sepsis patients had decreased GFR level. Conclusion:Â Neonatal sepsis patients often experienced decreased renal function.
Key Words: GFR, neonatal sepsis, renal function.
Â
Abstrak: Sepsis neonatorum merupakan respon sistemik terhadap infeksi yang disebabkan oleh bakteri, virus, jamur, dan protozoa dalam 28 hari pertama kehidupan setelah kelahiran. Pada sepsis neonatorum, terjadi inflamasi seluruh tubuh sebagai respon terhadap infeksi. Bila pada proses inflamasi tersebut tidak terdapat homeostasis antara sitokin proinflamatori dan antiinflamatori, maka akan terjadi proses inflamasi yang maladaptif dimana keadaan ini akan menyebabkan gangguan organ multipel (MODS/MOF) yang pada sepsis paling sering bermanifestasi sebagai gangguan ginjal akut. Penelitian ini bertujuan untuk mengetahui gambaran fungsi ginjal pada pasien sepsis neonatorum yang dirawat di RSUP Prof. Dr. R. D. Kandou periode Juli 2016 hingga Juni 2018. Jenis penelitian ialah deskriptif dengan desain potong lintang. Responden merupakan seluruh pasien sepsis neonatorum yang melakukan pemeriksaan fungsi ginjal dengan menggunakan pengukuran LFG (Laju Filtrasi Glomerulus) sebagai instrumen penelitian. Dari 405 sampel didapatkan bahwa 75,80% pasien sepsis neonatorum mengalami penurunan LFG. Kesimpulan: Pasien sepsis neonatorum sering mengalami penurunan fungsi ginjal.
Kata Kunci: Â Fungsi ginjal, LFG, sepsis neonatorum
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