Korelasi antara Rasio Limfosit Neutrofil dan Nilai Ambang Batas Siklus RT-PCR pada Bayi Terinfeksi Covid-19
DOI:
https://doi.org/10.35790/msj.v6i2.51694Abstract
Abstract: Covid-19 pandemic has been a new illness since the start of 2019 which was caused by SARS-CoV-2 coronavirus. In children, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has been linked to a multisystem inflammatory syndrome and coronavirus disease 2019 (Covid-19). This study aimed to obtain the correlation between the neutrophil-lymphocyte ratio (NLR) and the cycling threshold (CT) value (viral load) of RT-PCR for Covid-19 in infant patients. This was a descriptive and analytical study with a cross-sectional design. Secondary data were obtained from medical records of March 2020 to February 2022 at Prof. Dr. R. D. Kandou Hospital, Manado. Subjects were all infants admitted or born during the recording period, with suspected or confirmed Covid 19, including infants with mothers whose Covid-19 antigen tests were reactive. Data of age, gender, diagnosis, outcome CT value of RT-PCR test, and NLR were retrieved, and analyzed with Pearson correlation, meanwhile comparison based on gender and outcome of care using the independent T-test. All analyses were conducted with IBM SPSS 26.0. The results showed that the correlation between CT value and NLR was -0.361 with a p-value of 0.067. In conclusion, there is no significant correlation between CT value and NLR level with weak correlation. However, CT and NLR values appeared to be inversely associated; the higher the NLR value, the lower the CT value.
Keywords: infants; Covid-19; cycle threshold of RT-PCR; neutrophil-lymphocyte ratio
Abstrak: Pandemi Covid-19 menjadi penyakit baru sejak awal tahun 2019 sebagai akibat dari virus corona SARS-CoV-2. Pada anak, infeksi sindrom pernapasan akut parah coronavirus-2 (SARS-CoV-2) telah dikaitkan dengan sindrom inflamasi multisistem dan penyakit virus corona 2019 (Covid-19). Penelitian ini bertujuan untuk mengetahui hubungan antara rasio neutrofil-limfosit (NLR) dan nilai ambang batas siklus (CT) RT-PCR Covid-19 pada bayi. Jenis penelitian ialah deskriptif analitik dengan desain potong lintang. Data sekunder diperoleh dari rekam medis sejak Maret 2020 hingga Februari 2022 di RSUP Prof. Dr. R. D. Kandou Manado. Semua bayi yang dirawat atau lahir selama periode pencatatan, dengan suspek atau konfirmasi Covid-19, termasuk bayi dengan ibu yang tes antigen Covid-19-nya reaktif. Data yang dianalisis pada penelitian ini antara lain usia, jenis kelamin, diagnosis, nilai CT hasil tes RT-PCR, dan NLR. Analisis data yang dilakukan yaitu analisis deskriptif, korelasi Pearson, dan perbandingan berdasarkan jenis kelamin dan hasil perawatan dengan analisis uji t independen. Semua analisis dilakukan dengan software IBM SPSS 26.0. Hasil analisis menunjukkan nilai korelasi antara nilai CT dan NLR sebesar -0,361 (p=0,067). Simpulan penelitian ini ialah tidak terdapat hubungan bermakna antara nilai CT dan nilai NLR dengan korelasi yang lemah. Nilai CT dan NLR tampaknya berkorelasi terbalik dengan NLR yang lebih tinggi dikaitkan dengan nilai CT yang lebih rendah.
Kata kunci: bayi; Covid-19; nilai ambang batas siklus RT-PCR; rasio neutrofil-limfosit
References
Malcangi G, Inchingolo AD, Inchingolo AM, Piras F, Settanni V, Garofoli G, et al. COVID-19 Infection in children and infants: current status on therapies and vaccines. Children. 2022;9(2):1–28. Doi: 10.3390/children9020249
Huang X, Wei F, Hu L, Wen L, Chen K. Epidemiology and clinical characteristics of COVID-19. Arch Iran Med [Internet]. 2020;23(4):268–71. Doi: 10.34172/aim.2020.09
Pathak EB, Salemi JL, Sobers N, Menard J, Hambleton IR. Covid-19 in children in the United States: Intensive care admissions, estimated total infected, and projected numbers of severe pediatric cases in 2020. J Public Heal Manag Pract. 2020;26(4):325–33. Doi: 10.1097/PHH.0000000000001190
Ayed M, Alsafar Z, Bahzad Z, Buhamad Y, Abdulkareem A, AlQattan A, et al. Coronavirus infection in neonates: neurodevelopmental outcomes at 18 months of age. Can J Infect Dis Med Microbiol. 2023;2023(6140085):1–7. Doi: https://doi.org/10.1155/2023/6140085
Zhang J, Wang X, Jia X, Li J, Hu K, Chen G, et al. Risk factors for disease severity, unimprovement, and mortality in COVID-19 patients in Wuhan, China. Clin Microbiol Infect. 2020;26(6):767–72. Doi: 10.1016/j.cmi.2020.04.012
Prozan L, Shusterman E, Ablin J, Mitelpunkt A, Weiss-Meilik A, Adler A, et al. Prognostic value of neutrophil-to-lymphocyte ratio in COVID-19 compared with Influenza and respiratory syncytial virus infection. Sci Rep. 2021;11(1):1–8. Doi: 10.1038/s41598-021-00927-x
Yuki K, Fujiogi M, Koutsogiannaki S. Covid-19 pathophysiology: a review. Sci Clin. 2020;215 (108427):1–8. Doi: 10.1016/j.clim.2020.108427
Dhochak N, Singhal T, Kabra SK, Lodha R. Pathophysiology of Covid-19: Why children fare better than adults? Indian J Pediatr. 2020;87(7):537–46. Doi: 10.1007/s12098-020-03322-y
Penna C, Mercurio V, Tocchetti CG, Pagliaro P. Sex-related differences in Covid-19 lethality. Br J Pharmacol. 2020;177(19):4375–85. Doi: 10.1111/bph.15207
Arifputra J, Waleleng BJ, Gosal F, Wenas NT, Rotty L, Winarta J, et al. Liver transaminase levels and neutrophil to lymphocyte ratio as prognostic and predictor in coronavirus disease 2019. Open Access Maced J Med Sci. 2020;8(T1):282–5. Doi: https://doi.org/10.3889/oamjms.2020.5395
Kawatra S, Ranjan M, Singh S, Shveta. Correlation of hematological parameters to cycle threshold value of real time reverse transcriptase-polymerase chain reaction positive Covid-19 patients admitted in intensive care unit: study from a tertiary care center in Eastern India. Int J Pharm Clin Res. 2022;14(8):316–23. Available from: impactfactor.org/PDF/IJPCR/14/IJPCR,Vol14,Issue8, Article43.pdf
Xia XY, Wu J, Liu HL, Xia H, Jia B, Huang WX. Epidemiological and initial clinical characteristics of patients with family aggregation of Covid-19. J Clin Virol. 2020;127(104360):1–7. Doi: 10.1016/j.jcv.2020.104360
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Suryadi N. N. Tatura, Rifrita F. Halim
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
COPYRIGHT
Authors who publish with this journal agree to the following terms:
Authors hold their copyright and grant this journal the privilege of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that permits others to impart the work with an acknowledgment of the work's origin and initial publication by this journal.
Authors can enter into separate or additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (for example, post it to an institutional repository or publish it in a book), with an acknowledgment of its underlying publication in this journal.
Authors are permitted and encouraged to post their work online (for example, in institutional repositories or on their website) as it can lead to productive exchanges, as well as earlier and greater citation of the published work (See The Effect of Open Access).
