Hubungan Preeklamsia Berat dengan Kejadian Persalinan Preterm di RSUP Prof. Dr. R. D. Kandou Manado Periode 2021–2022
DOI:
https://doi.org/10.35790/msj.v6i2.53554Abstract
Abstract: Preeclampsia/eclampsia may lead to additional pregnancy complications, including the occurrence of preterm labor either spontaneously or be induced. Severe preeclampsia is a frequent reason for iatrogenic preterm labor. This study aimed to determine the relationship between severe preeclampsia and the incidence of preterm labor at Prof. Dr. R. D. Kandou Hospital, Manado, period 2021–2022. This was a case-control study design. The population in this study were mothers who gave birth at Prof. Dr. R. D. Kandou Hospital, Manado, from January 1st, 2021– December 31st, 2022. The case samples were mothers with preterm labor, meanwhile the control samples were mothers with term labor. Data were obtained from medical records of mothers who gave birth at the Obstetrics and Gynaecologist Department of Prof. Dr. R. D. Kandou Hospital. The chi square test showed that the most common preterm birth in severe preeclampsia was iatrogenic preterm labor (73.7%) and the most frequent indication was severe preeclampsia without impending eclampsia (43.9%). The chi-square test obtained a significant relationship between severe preeclampsia and the incidence of preterm labor (p=0.000, OR=2.359, 95% CI 1.709–3.773). In conclusion, there is a significant relationship between severe preeclampsia and the incidence of preterm labor at Prof. Dr. R. D. Kandou Hospital, Manado, period 2021–2022.
Keywords: severe preeclampsia; preterm labor; term labor
Abstrak: Preeklamsia/eklamsia dapat mengakibatkan masalah kehamilan lainnya, seperti persalinan preterm yang dapat terjadi secara spontan atau melalui tindakan iatrogenik (terminasi). Preeklamsia berat merupakan salah satu indikasi paling sering pada persalinan preterm yang dilakukan secara iatrogenik. Penelitian ini bertujuan untuk mengetahui hubungan preeklamsia berat dengan kejadian persalinan preterm di RSUP Prof. Dr. R. D. Kandou Manado periode 2021–2022. Jenis penelitian ialah deskriptif analitik dengan desain studi kasus-kontrol. Sampel kasus ialah ibu dengan persalinan preterm dan sampel kontrol ialah ibu dengan persalinan aterm yang didapatkan dari data rekam medik ibu bersalin di Bagian Obstetri Ginekologi RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian memperlihatkan bahwa persalinan preterm terbanyak pada preeklamsia berat ialah persalinan preterm iatrogenik (terminasi) (73,7%) dan indikasi terbanyak ialah preeklamsia berat tanpa impending eklamsia (43,9%). Hasil uji chi square mendapatkan hubungan bermakna antara preeklamsia berat dan persalinan preterm (p=0,000; OR=2,539, 95% CI 1,709-3,773). Simpulan penelitian ini ialah terdapat hubungan bermakna antara preeklamsia berat dengan kejadian persalinan preterm di RSUP Prof Dr. R. D. Kandou Manado periode 2021–2022.
Kata kunci: preeklamsia berat; persalinan preterm; persalinan aterm
References
Espinoza J, Vidaeff A, Pettker CM, Simhan H. ACOG Practice Bulletin Clinical Management Guidelines for Obstetrician-Gynecologists. 2020. Available from: http://journals.lww.com/greenjournal
EL-Adl RM, Eid M, Shalan H, Hussien M. Maternal, fetal and neonatal outcomes of severe preeclampsia in Mansoura University Hospitals: a prospective study. Mans Med J. 2021;50(4):154–62. Doi: 10.21608/mjmu.2021.95521.1038
Karrar SA, Long PL. Preeclampsia continuing education activity. StatPearls Publishing [Internet]. 2023;1. Available from: https://www.ncbi.nlm.nih.gov/books/NBK570611/
Wibowo N, Irwinda R, Frisdiantiny E, Karkata MK, Mose JC, Chalid MT, et al. Diagnosis dan tatalaksana pre-eklamsia [Internet]. 2016. Available from: https://www.pogi.or.id/wp-content/uploads/ download-manager-files/PNPK%20PreEklampsia%202016.pdf
Magee LA, Pels A, Helewa M, Rey E, von Dadelszen P, Audibert F, et al. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary. J Obstet Gynaecol Can. 2014;36(5):416-41. Doi: 10.1016/s1701-2163(15)30588-0
World Health Organization. The global action report on preterm birth born too soon [Internet]. 2012. Available from: https://iris.who.int/bitstream/handle/10665/44864/9789241503433_eng.pdf? sequence=1
World Health Organization. Born too soon decade of action on preterm birth [Internet]. Geneva; 2023. Available from: https://who.int/publications/i/item/9789240073890
An H, Jin M, Li Z, Zhang L, Li H, Zhang Y, et al. Impact of gestational hypertension and pre-eclampsia on preterm birth in China: a large prospective cohort study. BMJ Open. 2022;12(9):e058068. Doi: 10.1136/bmjopen-2021-058068
Wen Y, Yang X. Clinical comparison of preterm birth and spontaneous preterm birth in severe preeclampsia. Contrast Media Mol Imaging. 2022;2022:1995803. Doi: 10.1155/2022/1995803
Nopalia P, Purwanti H, Masyita G, Wahyuni R. Hubungan preeklamsi dengan persalinan preterm. Jurnal Ilmiah Multi Disiplin Indonesia [Internet]. 2023;2(8):17916. Available from: https://journal.ikopin. ac.id/index.php/humantech/article/view/3294
Tessema GA, Tekeste A, Ayele TA. Preeclampsia and associated factors among pregnant women attending antenatal care in Dessie referral hospital, Northeast Ethiopia: a hospital-based study. BMC Pregnancy Childbirth. 2015;15(1):73. Doi: 10.1186/s12884-015-0502-7
van Katwijk C. Clinical aspects of pregnancy after the age of 35 years: a review of the literature. Hum Reprod Update. 1998;4(2):185–94. Available from: https://academic.oup.com/humupd/article-lookup/doi/10.1093/humupd/4.2.185
Lisonkova S, Bone JN, Muraca GM, Razaz N, Wang LQ, Sabr Y, et al. Incidence and risk factors for severe preeclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome, and eclampsia at preterm and term gestation: a population-based study. Am J Obstet Gynecol. 2021;225(5):538.e8. Available from: https://doi.org/10.1016/j.ajog.2021.04.261
Youssef AEDA, Mohamed MH, Habib DMES, Moussa SS. Effect of socioeconomic status on preeclampsia cross sectional study. Med J Cairo Univ. 2018;86(7):4229. Available from: www.medicaljournalofcairouniversity.net
Cunningham FG, Leveno KJ, Dashe JS, Hoffman BL, Spong CY, Casey BM, editors. Williams Obstetrics (26th ed). Mc Graw Hill; 2022. Available from: https://books.google.co.id/books?id=2HVKEAA AQBAJ&q=williams+obstetrics+26th+pdf+free+download&dq=williams+obstetrics+26th+pdf+free+download&hl=en&newbks=1&newbks_redir=1&printsec=frontcover&sa=X&ved=2ahUKEwjaoPzRgMiDAxWNd2wGHQfJCmkQ6AF6BAgNEAI
Grum T, Seifu A, Abay M, Angesom T, Tsegay L. Determinants of pre-eclampsia/Eclampsia among women attending delivery services in selected public hospitals of Addis Ababa, Ethiopia: a case control study. BMC Pregnancy Childbirth. 2017;17(1):3-7. Doi: 10.1186/s12884-017-1507-1
Granés L, Torà-Rocamora I, Palacio M, De La Torre L, Llupià A. Maternal educational level and preterm birth: Exploring inequalities in a hospital-based cohort study. PLoS One. 2023;18(4):e0283901. Doi: 10.1371/journal.pone.0283
Rasmussen S, Ebbing C, Irgens LM. Predicting preeclampsia from a history of preterm birth. PLoS One. 2017;12(7):e0181016. Doi: 10.1371/journal.pone.0181016
dos Santos XT, Rodrigues AOC, de Souza BE, Alves LLÁ, Dittz JD, Vogt ES, et al. Labor induction in women with pre-eclampsia: maternal and neonatal outcomes. Rev Med Minas Gerais [Internet]. 2023;33(e-33103):4. Available from: https://rmmg.org/exportar-pdf/3970/en_e33103.pdf
von Dadelszen P, Syngelaki A, Akolekar R, Magee LA, Nicolaides KH. Preterm and term pre-eclampsia: Relative burdens of maternal and perinatal complications. BJOG. 2023;130(5):527. Doi: 10.1111/1471-0528.17370
Davies EL, Bell JS, Bhattacharya S. Preeclampsia and preterm delivery: a population-based case–control study. Hypertens Pregnancy. 2016;35(4):510–9. Available from: https://doi.org/10.1080/ 10641955. 2016.1190846
Nurul HG, Nurlaella HE. Hubungan antara persalinan preterm dengan preeklampsia pada ibu bersalin di RSUD Sumedang. Jurnal Penelitian Kesehatan Suara Forikes. 2022;13(1):214. Available from: http://forikes-ejournal.com/index.php/SF
Gumay DO, Wijayanegara H, Zulmansyah. Hubungan preeklamsi berat dengan hasil luaran janin (fetal outcome) di RSUD Al-Ihsan Kabupaten Bandung. Global Medical & Health Communication (GMHC). 2015;3(2):53. Available from: http://ejournal.unisba.ac.id/index.php/gmhc/article/view/1546
Liu CM, Cheng PJ, Chang SD. Maternal complications and perinatal outcomes associated with gestational hypertension and severe preeclampsia in Taiwanese women. Journal of the Formosan Medical Association. 2008;107(2):129–38. Available from: https://linkinghub.elsevier.com/retrieve/pii/ S0929664608601266
Muti M, Tshimanga M, Notion GT, Bangure D, Chonzi P. Prevalence of pregnancy induced hypertension and pregnancy outcomes among women seeking maternity services in Harare, Zimbabwe. BMC Cardiovasc Disord. 2015;15(1):111. Doi: 10.1186/s12872-015-0110-5
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Cresensia R. N. Widjaja, Erna Suparman, John J. E. Wantania
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
COPYRIGHT
Authors who publish with this journal agree to the following terms:
Authors hold their copyright and grant this journal the privilege of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that permits others to impart the work with an acknowledgment of the work's origin and initial publication by this journal.
Authors can enter into separate or additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (for example, post it to an institutional repository or publish it in a book), with an acknowledgment of its underlying publication in this journal.
Authors are permitted and encouraged to post their work online (for example, in institutional repositories or on their website) as it can lead to productive exchanges, as well as earlier and greater citation of the published work (See The Effect of Open Access).
