Gambaran Fungsi Ginjal Pasien PJK dengan Oklusi Total Kronik yang Menjalani IKP di RSUP Prof. Dr. R. D. Kandou Manado Periode Januari-Desember 2022
DOI:
https://doi.org/10.35790/msj.v7i1.54929Abstract
Abstract: Accumulation of fat on the walls of blood vessels can affect blood flow to the heart muscles which has an impact on heart and kidney functions. This study aimed to obtain the description of kidney function in patients with coronary artery disease (CAD) with chronic total occlusion (CTO) who underwent percutaneous coronary intervention (PCI). This was a retrospective and descriptive study with a cross-sectional design. Samples were CAD patients with CTO registered in medical records of Prof. Dr. R. D. Kandou Hospital from January to December 2022. The results showed that there were 95 cases of CTO who underwent PCI. There were 36 (37.9%) patients with increased creatinine levels and decreased eGFR including 33 (34.7%) males, 20 (43.5%) aged 45-59 years, seven (7.4%) with hypertension. There were six patients (16.7%) with contrast induced nephropathy (CIN) including five (13.9%) males, three (8.3%) aged ≥70 years, and two (5.6%) with dyslipidemia. In conclusion, elevated creatinine levels and decreased eGFR are more common in males, pre-elderly, and with hypertension, meanwhile contrast induced nephropathy is more common in males, high-risk elderly, and with dyslipidemia as comorbid.
Keywords: kidney function; coronary heart disease; chronic total occlusion; percutaneous coronary intervention
Abstrak: Penumpukan lemak pada dinding pembuluh darah dapat memengaruhi aliran darah ke otot jantung yang berdampak pada fungsi jantung dan ginjal. Penelitian ini bertujuan untuk mengetahui gambaran fungsi ginjal pasien penyakit jantung coroner (PJK) dengan oklusi total kronik (OTK) yang menjalani intervensi koroner perkutan (IKP). Jenis penelitian ialah deskriptif retrospektif dengan desain potong lintang. Sampel penelitian ialah pasien PJK dengan OTK yang tercatat di Rekam Medik RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Desember 2022. Hasil penelitian mendapatkan 95 kasus OTK yang menjalani IKP. Terdapat 36 (37,9%) mengalami peningkatan kadar kreatinin dan penurunan eGFR di antaranya 33 (34,7%) laki-laki, 20 (43,5%) berusia 45-59 tahun, tujuh (7,4%) dengan hipertensi. Terdapat enam pasien (16,7%) yang mengalami contrast induced nephropathy (CIN) diantaranya lima (13,9%) laki-laki, tiga (8,3%) berusia ≥70 tahun, dan dua (5,6%) dengan dislipidemia. Simpulan penelitian ini ialah peningkatan kadar kreatinin dan penurunan eGFR sering terjadi pada laki-laki, kelompok pra lanjut, dengan hipertensi sedangkan contrast induced nephropathy sering terjadi pada pasien laki-laki, usia lanjut berisiko tinggi dan penyakit penyerta dislipidemia.
Kata kunci: fungsi ginjal; penyakit jantung koroner; oklusi total kronik; intervensi koroner perkutan
References
WHO reveals leading causes of death and disability worldwide: 2000-2019 [Internet]. [cited 2023 Jul 16]. Available from: https://www.who.int/news/item/09-12-2020-who-reveals-leading-causes- of-death-and-disability-worldwide-2000-2019
Dharma S. Penyakit arteri koroner. In: Rampengan N, editor. Kapita Selekta Kardiologi (1st ed). Jakarta: Badan Penerbit FK UI; 2018. p. 135–220.
Holck EN, Winther NS, Mogensen LJH, Christiansen EH. Chronic total occlusion is not a risk factor for mortality in patients with successful percutaneous coronary intervention: a cohort study. J Am Heart Assoc. 2023;12(20):e030989. Available from: http://www.ncbi.nlm.nih.gov/pubmed/37830355
Liu Y, Liu YH, Chen JY, Tan N, Zhou YL, Duan CY, et al. Safe contrast volumes for preventing contrast-induced nephropathy in elderly patients with relatively normal renal function during percutaneous coronary intervention. Medicine. 2015;94(12):e615. Available from: https://pubmed.ncbi.nlm.nih.gov/25816028/
Abstract 20748: The Impact of Calcification in Chronic Total Occlusion Percutaneous Coronary Intervention: Insights from a Contemporary Multicenter Registry | Circulation [Internet]. [cited 2023 Dec 13]. Available from: https://www.ahajournals.org/doi/10.1161/circ.134.suppl_1.20748
Melyani, Tambunan LN, Baringbing EP. Hubungan usia dengan kejadian penyakit jantung koroner pada pasien rawat jalan di RSUD dr. Doris Sylvanus Provinsi Kalimantan Tengah. Jurnal Surya Medika. 2023;9(1):119–25. Available from: http://journal.umpalangkaraya.ac.id/index.php/jsm
Gong X, Zhou L, Ding X, Chen H, Li H. The impact of successful chronic total occlusion percutaneous coronary intervention on long-term clinical outcomes in real world. BMC Cardiovasc Disord. 2021;21(1):182. Available from: https://pubmed.ncbi.nlm.nih.gov/33858349/
Chon MK, Chun KJ, Lee DS, Lee SY, Hwang J, Lee SH, et al. Radiation reduction during percutaneous coronary intervention: a new protocol with a low frame rate and selective fluoroscopic image storage. Medicine. 2017;96(30):e7517. Doi: 10.1097/MD.0000000000007517
Suseno I, Martha J, Purnomowati A, Aprami T. Prevalensi dan karakteristik penderita penyakit jantung koroner dengan chronic total occlusion di Rumah Sakit Hasan Sadikin periode tahun 2013 [Internet]. 2014 [cited 2024 Jan 8]. Available from: https://pustaka.unpad.ac.id/archives/tag/chronic-total-occlusions-cto
Reaginta T. Pemeriksaan kadar kreatinin pada penderita jantung koroner yang berobat di Rumah Sakit Umum Pusat Haji Adam Malik Medan. 2019. [cited 2023 Dec 19]. Available from: http://ecampus.poltekkes-medan.ac.id/xmlui/handle/123456789/1554
Aryaningsih R. gambaran kadar kreatinin serum pada penderita hipertensi di RSUD Tabanan [Diploma Tesis]. Denpasar: Politeknik Kesehatan; 2023 [cited 2024 Jan 8]. Available from: http://repository.poltekkes-denpasar.ac.id/id/eprint/10728
Evola S, Lunetta M, MacAione F, Fonte G, Milana G, Corrado E, et al. Risk factors for contrast induced nephropathy: A study among Italian patients. Indian Heart J. 2012;64(5):484. Available from: /pmc/articles/PMC3860804/
Modi K, Padala SA, Gupta M. Contrast-induced nephropathy. 2023 Jul 24 [cited 2023 Nov 22]. Treasure Island (FL): StatPearls Publishing; 2024 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK448066/
Cho E, Ko GJ. The pathophysiology and the management of radiocontrast-induced nephropathy. Diagnostics. 2022;12(1):180. Available from: https://www.mdpi.com/2075-4418/12/1/180/htm
André R, Dumonteil N, Lhermusier T, Lairez O, Van Rothem J, Fournier P, et al. In-hospital and long-term outcomes after percutaneous coronary intervention for chronic total occlusion in elderly patients: a consecutive, prospective, single-centre study. Arch Cardiovasc Dis. 2016;109(1):13–21. Available from: https://pubmed.ncbi.nlm.nih.gov/26507531/
Xu R, Zhang LX, Zhang PH, Wang F, Zuo L, Wang HY. Gender differences in age-related decline in glomerular filtration rates in healthy people and chronic kidney disease patients. BMC Nephrol. 2010;11:20. Available from: https://pubmed.ncbi.nlm.nih.gov/20731848/
Kristin AM, Panda AL, Pangemanan J. Gambaran fungsi ginjal pada penderita sindrom koroner akut. e-CliniC. 2016;4(1):243-8. Available from: https://ejournal.unsrat.ac.id/index.php/eclinic/article/view/10962
Yu Z, Rebholz CM, Wong E, Chen Y, Matsushita K, Coresh J, et al. Association between hypertension and kidney function decline: The Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis, 2019;74(3):310–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760841/
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Ni Made Anjani, Agnes L. Panda, Edmond L. Jim
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
COPYRIGHT
Authors who publish with this journal agree to the following terms:
Authors hold their copyright and grant this journal the privilege of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that permits others to impart the work with an acknowledgment of the work's origin and initial publication by this journal.
Authors can enter into separate or additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (for example, post it to an institutional repository or publish it in a book), with an acknowledgment of its underlying publication in this journal.
Authors are permitted and encouraged to post their work online (for example, in institutional repositories or on their website) as it can lead to productive exchanges, as well as earlier and greater citation of the published work (See The Effect of Open Access).
