Hubungan Faktor Risiko Penyakit Jantung Koroner dengan Insidens Kejadian Kardiovaskular Mayor pada Pasien STEMI yang Menjalani IKP Primer di RSUP Prof Dr. R. D. Kandou Manado Periode Januari - Desember 2022
DOI:
https://doi.org/10.35790/msj.v7i1.56486Abstract
Abstract: Major adverse cardiovascular events (MACE) are adverse outcomes in ST elevation myocardial infarction (STEMI) patients, such as death, recurrent myocardial infarction, stroke, rehospitalization, and recurrent revascularization. The occurrence of MACE depends on the patient's age, gender, and lifestyle. This study aimed to determine the relationship between coronary heart disease risk factors and the incidence of MACE in STEMI patients undergoing primary PCI (PPCI). Samples were STEMI patients undergoing PPCI at Prof. Dr. R. D. Kandou Hospital, from January to December 2022. This was a retrospective cohort study using the consecutive sampling method. Data were analyzed using the chi-square test and Fisher's exact test. The results obtained 169 cases STEMI patients undergoing PPCI; 80 of them fulfilled the inclusion criteria. The majority of patients did not experience MACE. The most common type of MACE was rehospitalization. The bivariate analysis, it showed that there was no significant relationship between coronary heart disease risk factors and MACE in STEMI patients undergoing PPCI. In conclusion, there is no significant relationship between coronary heart disease risk factors and major adverse cardiovascular events.
Keywords: major adverse cardiovascular events; coronary heart disease; risk factors
Abstrak: Kejadian kardiovaskular mayor (KKM) merupakan hasil akhir yang merugikan pada pasien dengan ST elevation myocardial infarction (STEMI), berupa kematian, infark miokard berulang, stroke, rehospitalisasi, dan revaskularisasi berulang. Terjadinya KKM bergantung pada usia, jenis kelamin, dan faktor gaya hidup pasien. Penelitian ini bertujuan untuk mengetahui hubungan antara faktor risiko penyakit jantung koroner dengan insidens KKM pada pasien STEMI. Sampel penelitian ialah pasien STEMI yang menjalani IKP Primer di RSUP Prof. Dr. R. D. Kandou Manado periode Januari - Desember 2022. Jenis penelitian ialah cohort retrospektif dengan metode consecutive sampling. Uji statistik ialah analisis univariat dan analisis bivariat menggunakan uji chi square dan uji Fisher’s exact. Hasil penelitian mendapatkan 169 penderita STEMI yang menjalani IKP primer dengan 80 sampel yang memenuhi kriteria inklusi. Sebagian besar pasien tidak mengalami KKM. Jenis KKM yang paling banyak ditemukan ialah rehospitalisasi. Berdasarkan analisis bivariat, tidak didapatkan hubungan bermakna antara faktor risiko penyakit jantung koroner dengan kejadian kardiovaskular mayor pada pasien STEMI yang menjalani IKP Primer. Simpulan penelitian ini ialah tidak terdapat hubungan bermakna antara faktor risiko penyakit jantung koroner dengan kejadian kardiovaskular mayor.
Kata kunci: kejadian kardiovaskular mayor; penyakit jantung coroner; faktor risiko
References
Setiati Si, Alwi I, Sudoyo AW, Simadibrata M, Setiyohadi B, Syam AF, editors. Buku Ajar Ilmu Penyakit Dalam (6th ed). Jakarta: InternaPublishing; 2014. p. 1457–74, 1555, 3417.
Rampengan SH, Akbar MR, Dharma S, Mappangara I, Gunadhi IGN, Prakoso R, et al. Kapita Selekta Kardiologi. Rampengan NH, editor. Jakarta: Badan Penerbit Fakultas Kedokteran Indonesia; 2018. p. 142–72.
Perhimpunan Dokter Spesialis Kardiovaskular Indonesia. Pedoman Tata Laksana Sindrom Koroner Akut [Internet]. Indonesian Heart Association Perhimpunan Dokter Spesialis Kardiovaskular (PERKI); 2018. 1–2 p. Available from: https://www.inaheart.org/guidelines/pedoman-tatalaksana-sindrom-koroner-akut-2018
Poudel I, Tejpal C, Rashid H, Jahan N. Major adverse cardiovascular events: an inevitable outcome of ST-elevation myocardial infarction? A literature review. Cureus. 2019;11(7):e5280. Available from: https://www. ncbi.nlm.nih.gov/pmc/articles/PMC6695291/
Samir A, Almahjori M, Zarif B, Elshinawi M, Yehia H, Elhafy M, et al. Characterization of features and outcomes of young patients (<45 years) presenting with ST-segment elevation myocardial infarction. Egyptian Heart Journal. 2023;75(1):32. Available from: https://tehj.springeropen.com/articles/10.1186/s43044-023-00357-2
Suridanda Danny S, Roebiono PS, Mardiani Soesanto A, Kasim M. Factors influencing major cardiovascular event post acute myocardial infarction in woman. Jurnal Kardiologi Indonesia. 2009;30(1):3–12. Available from: https://ijconline.id/index.php/ijc/article/download/171/175/
Harvey A, Montezano AC, Lopes RA, Rios F, Touyz RM. Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications. Canadian Journal of Cardiology. 2016;32(5):659–68. Doi: 10.1016/j.cjca.2016.02.070
Gaba P, Gersh BJ, Ali ZA, Moses JW, Stone GW. Complete versus incomplete coronary revascularization: definitions, assessment and outcomes. Nature Reviews Cardiology. 2021;18(3):155–68. Available from: https://pubmed.ncbi.nlm.nih.gov/33067581/
Nagaraja V, Ooi S, Nolan J, Large A, De Belder M, Ludman P, et al. Impact of incomplete percutaneous revascularization in patients with multivessel coronary artery disease: a systematic review and meta‐analysis. J Am Heart Assoc. 2016;5(12):1–23. Available from: https://www.ahajournals.org/doi/ 10.1161/JAHA.116.004598
Rizkita N, Yanni M, Miro S. Lokasi Infark memengaruhi kejadian kardiovaskular mayor pasien IMA-EST yang menjalani late intervensi koroner perkutan. Jurnal Ilmu Kesehatan Indonesia. 2022;2(4):224–32. Available from: http://jikesi.fk.unand.ac.id/index.php/jikesi/article/view/336
Sun Y, Feng L, Li X, Gao R, Wu Y. The sex difference in 6-month MACEs and its explaining variables in acute myocardial infarction survivors: data from CPACS-3 study. Int J Cardiol. 2020;311:1–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/32223960
Kanic V, Vollrath M, Naji FH, Sinkovic A. Gender related survival differences in ST-elevation myocardial infarction patients treated with primary PCI. International Journal of Medical Sciences. 2016;13(6):440–4. Available from: http://www.medsci.org/v13p0440.htm
Wahyuni SH. Usia, Jenis kelamin dan riwayat keluarga penyakit jantung sebagai faktor predikator terjadinya major adverse cardiac events pada pasien sindrom koroner akut [Skripsi]. Jakarta: Universitas Islam Negeri Syarif Hidayatullah; 2014; Available from: https://repository.uinjkt.ac.id/dspace/bitstream/123456789/25794/1/ SISKA HESTU WAHYUNI-FKIK.pdf
Reindl M, Holzknecht M, Tiller C, Lechner I, Schiestl M, Simma F, et al. Impact of Infarct location and size on clinical outcome after ST-elevation myocardial infarction treated by primary percutaneous coronary intervention. Int J Cardiol. 2020;301:14-20. Doi: 10.1016/j.ijcard.2019.11.123
Zhang L, Wang Z, Liu X, Zhou Z, Zhao Y, Shi D, et al. Women with early menopause have higher rates of target lesion revascularization after percutaneous coronary intervention. Angiology. 2016;67(4):311–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26032851
Nasution SA, Perkasa H, Ginanjar E, Rinaldi I. In-hospital major adverse cardiac events factor predictors on ST-elevation myocardial infarction after primary percutaneous coronary intervention at dr. Cipto Mangunkusumo General Hospital. eJournal Kedokteran Indonesia. 2022;10(2):107–13. Available from: https://ejki.fk.ui.ac.id/index.php/journal/article/view/193
Sattari PG. Hubungan hipertensi terhadap kejadian kardiovaskular mayor pada pasien infark miokard akut yang dirawat di RSUD Raden Mattaher Provinsi Jambi pada tahun 2021. 2022. Available from: https://repository.unja.ac.id/43712/3/SKRIPSI PANDELA GIBRAN SATTARI G1A119035.pdf
Kristin E, Dinarti LK, Febrinasari R, Pratiwi WR, Yasmina A, Jaya SI. Persistence to antihypertensive and clinical outcomes in acute coronary syndrome patients after percutaneous coronary intervention. Indones J Pharm. 2023;34(3):482–90. Available from: https://journal.ugm.ac.id/v3/IJP/article/view/5499
Mohammed MAH, Sanip Z, Yusof Z, W. Isa WYH. Risk factors for major adverse cardiac events outcomes in post percutaneous coronary intervention during index admission. Malaysian Journal of Medicine and Health Sciences. 2023;19(4):130–8. Available from: https://medic.upm.edu.my/upload/dokumen/ 2023072015174319_MJMHS_1064.pdf
Pedoman Pengelolaan Dislipidemi di Indonesia 2019. PB Perkeni. 2019. Available from: https://pbperkeni.or.id/wp-content/uploads/2021/06/Panduan-pengelolaan-dislipidemia-2019-eBook-PDF.pdf
Azaza N, Baslaib FO, Al Rishani A, Ahmed M, Al-Zainal J, Aboalela M, et al. Predictors of the development of major adverse cardiac events following percutaneous coronary intervention. Dubai Medical Journal. 2022;5(2):117–21. Available from: https://www.karger.com/Article/FullText/522481
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Feiby C. Toliu, Victor F. F. Joseph, Starry H. Rampengan
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
COPYRIGHT
Authors who publish with this journal agree to the following terms:
Authors hold their copyright and grant this journal the privilege of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that permits others to impart the work with an acknowledgment of the work's origin and initial publication by this journal.
Authors can enter into separate or additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (for example, post it to an institutional repository or publish it in a book), with an acknowledgment of its underlying publication in this journal.
Authors are permitted and encouraged to post their work online (for example, in institutional repositories or on their website) as it can lead to productive exchanges, as well as earlier and greater citation of the published work (See The Effect of Open Access).