Resection of Distal Radius Giant Cell Tumor and Reconstruction with Non-Vascularized Fibular Graft: A Case Report

Authors

  • Stefan A. G. P. Kambey Universitas Sam Ratulangi
  • Rangga B. V. Rawung Universitas Sam Ratulangi
  • Tooy D. Christorei Universitas Sam Ratulangi

DOI:

https://doi.org/10.35790/msj.v8i1.63895

Keywords:

giant cell tumor; fibular graft; distal radius; reconstruction

Abstract

Abstract: Giant cell tumor (GCT) is a benign and locally aggressive tumor. Cases of GCT found at the distal radius were rare and difficult to control locally. We reported a case of GCT with en bloc resection and reconstruction using non-vascularized fibular autograft. A 57-year-old female patient presented with a lump on the wrist joint of left arm, and was confirmed to have a giant cell tumor by histological study. The tumor was classified as a Campanacci Grade III tumor, therefore, an en bloc resection with non-vascularized fibular autograft was performed. Arthrodesis was added to increase stability. Resection with a clear margin, with no complications, was possible despite not previously receiving downsizing neoadjuvant chemotherapy. Acceptable functional results were achieved postoperatively; however, wrist motion was reduced due to the arthrodesis. Long-term follow-up should consider recurrence and graft-related complications, including fractures, dislocations, or subluxations. In conclusion, while there is no general consensus of how to treat GCT, the Campannaci classification is useful to make a surgical decision. Resection and reconstruction with non-vascularized fibular autograft were satisfactory, having achieved free margin resection. However, there is a decreased range of motion due to arthrodesis of wrist, in order to prevent subluxation and dislocation. Long term follow up is necessary to observe recurrences and complications related to bone autograft utilization.

Keywords: giant cell tumor; fibular graft; distal radius; reconstruction

Author Biographies

Stefan A. G. P. Kambey, Universitas Sam Ratulangi

Division of Orthopedic Surgery, Department of Surgery, Faculty of Medicine, Universitas Sam Ratulangi - Prof. Dr. R. D. Kandou Hospital, Manado, Indonesia

Rangga B. V. Rawung, Universitas Sam Ratulangi

Division of Orthopedic Surgery, Department of Surgery, Faculty of Medicine, Universitas Sam Ratulangi -  Prof. Dr. R. D. Kandou Hospital, Manado, Indonesia

Tooy D. Christorei, Universitas Sam Ratulangi

Abstract: Giant cell tumor (GCT) is a benign and locally aggressive tumor. Cases of GCT found at the distal radius were rare and difficult to control locally. We reported a case of GCT with en bloc resection and reconstruction using non-vascularized fibular autograft. A 57-year-old female patient presented with a lump on the wrist joint of left arm, and was confirmed to have a giant cell tumor by histological study. The tumor was classified as a Campanacci Grade III tumor, therefore, an en bloc resection with non-vascularized fibular autograft was performed. Arthrodesis was added to increase stability. Resection with a clear margin, with no complications, was possible despite not previously receiving downsizing neoadjuvant chemotherapy. Acceptable functional results were achieved postoperatively; however, wrist motion was reduced due to the arthrodesis. Long-term follow-up should consider recurrence and graft-related complications, including fractures, dislocations, or subluxations. In conclusion, while there is no general consensus of how to treat GCT, the Campannaci classification is useful to make a surgical decision. Resection and reconstruction with non-vascularized fibular autograft were satisfactory, having achieved free margin resection. However, there is a decreased range of motion due to arthrodesis of wrist, in order to prevent subluxation and dislocation. Long term follow up is necessary to observe recurrences and complications related to bone autograft utilization.

Keywords: giant cell tumor; fibular graft; distal radius; reconstruction

References

1. Hosseinzadeh S, Tiwari V, De Jesus O. Giant cell tumor (osteoclastoma) [Updated 2024 Jan 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559229/

2. Beebe-Dimmer JL, Cetin K, Fryzek JP, Schuetze SM, Schwartz K. The epidemiology of malignant giant cell tumors of bone: an analysis of data from the Surveillance, Epidemiology and end results program (1975-2004). Rare Tumors. 2009;1(2):e52. Doi: 10.4081/rt.2009.e52

3. Parmeggiani A, Miceli M, Errani C, Facchini G. State of the art and new concepts in giant cell tumor of bone: imaging features and tumor characteristics. Cancers (Basel). 2021;13(24):6298. Doi: 10.3390/cancers13246298

4. Sobti A, Agrawal P, Agarwala S, Agarwal M. Giant cell tumor of bone - an overview. Arch Bone Jt Surg. 2016;4(1):2-9. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4733230/

5. Singh VA, Koh TW, Haseeb A, Yasin NF. Functional outcome following excision of giant cell tumour of the distal radius and reconstruction by autologous non-vascularized osteoarticular fibula graft. J Orthop Surg (Hong Kong). 2022;30(1):23094990221074103. Doi: 10.1177/23094990221074103

6. Taraz-Jamshidi MH, Gharadaghi M, Mazloumi SM, Hallaj-Moghaddam M, Ebrahimzadeh MH. Clinical outcome of en-block resection and reconstruction with nonvascularized fibular autograft for the treatment of giant cell tumor of distal radius. J Res Med Sci. 2014;19(2):117-21. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC3999596/

7. Panchwagh Y, Puri A, Agarwal M, Anchan C, Shah M. Giant cell tumor - distal end radius: Do we know the answer? Indian J Orthop. 2007;41(2):139-45. Doi: 10.4103/0019-5413.32046

8. Agrawal AC, Garg AK, Choudhary R, Verma S, Dash RN. Giant cell tumor of the distal radius: wide resection, ulna translocation with wrist arthrodesis. Cureus. 2021;13(5):e15034. Doi: 10.7759/cureus.15034

9. Wysocki RW, Soni E, Virkus WW, Scarborough MT, Leurgans SE, Gitelis S. Is intralesional treatment of giant cell tumor of the distal radius comparable to resection with respect to local control and functional outcome? Clin Orthop Relat Res. 2015;473(2):706-15. Doi: 10.1007/s11999-014-4054-3

10. Koucheki R, Gazendam A, Perera J, Griffin A, Ferguson P, Wunder J, et al. Management of giant cell tumors of the distal radius: a systematic review and meta-analysis. Eur J Orthop Surg Traumatol. 2023;33(4):759-772. Doi: 10.1007/s00590-022-03252-9

11. Peng-Fei S, Yu-Hua J. Reconstruction of distal radius by fibula following excision of grade III giant cell tumour: follow-up of 18 cases. Int Orthop. 2011 Apr;35(4):577-80. Doi: 10.1007/s00264-010-0967-y

12. Taqi M, Llewellyn CM, Estefan M. Fibula tissue transfer. [Updated 2023 Jan 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK563283/

13. Liu S, Tao S, Tan J, Hu X, Liu H, Li Z. Long-term follow-up of fibular graft for the reconstruction of bone defects. Medicine (Baltimore). 2018 Oct;97(40):e12605. Doi: 10.1097/MD.0000000000012605

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Published

2025-11-23

How to Cite

Kambey, S. A. G. P., Rawung, R. B. V., & Christorei, T. D. (2025). Resection of Distal Radius Giant Cell Tumor and Reconstruction with Non-Vascularized Fibular Graft: A Case Report. Medical Scope Journal, 8(1), 207–211. https://doi.org/10.35790/msj.v8i1.63895