Hubungan Penggunaan Dopamin Agonis dengan Kualitas Tidur pada Pasien Parkinson
DOI:
https://doi.org/10.35790/msj.v8i2.67062Keywords:
penyakit Parkinson; dopamin agonis; kualitas tidur; simtom nonmotorikAbstract
Abstract: Parkinson’s disease is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms, including sleep disturbances that reduce quality of life. Dopamine agonists such as pramipexole and ropinirole not only improve motor symptoms but may also affect sleep quality in Parkinson’s disease patients. This study aimed to evaluate the correlation between the use of dopamine agonist and sleep quality in Parkinson’s disease patients. This was an analytical and observational study using a cross-sectional design, involving 34 outpatient Parkinson’s disease patients at the CVBC Neurology Clinic of Prof. Dr. R. D. Kandou Hospital in September 2025. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and data were analyzed with the chi-square test. The results showed that of the 34 patients, 18 used dopamine agonists and 16 did not. Good sleep quality was observed in 72.2% of dopamine agonist users compared with 25% of non-users. There were significant correlations between dopamine agonist use and sleep quality (p=0.006), and between age and sleep quality (p=0.010). Meanwhile, sex, comorbidities, and disease duration did not show significant correlations. In conclusion, there is a significant correlation between the use of dopamine agonist and sleep quality in Parkinson’s disease patients. Dopamine agonist users tend to have better sleep quality than those who do not use them.
Keywords: Parkinson’s disease; dopamine agonists; sleep quality; non-motor symptoms
Abstrak: Penyakit Parkinson (PP) merupakan gangguan neurodegeneratif progresif dengan gejala motorik dan nonmotorik, termasuk gangguan tidur yang dapat menurunkan kualitas hidup pasien. Dopamin agonis seperti pramipeksol dan ropinirol tidak hanya memperbaiki gejala motorik tetapi juga diduga berpengaruh terhadap kualitas tidur pasien PP. Penelitian ini bertujuan untuk mengetahui hubungan antara penggunaan dopamin agonis dengan kualitas tidur pada pasien PP. Jenis penelitian ialah observasional analitik dengan desain potong lintang yang melibatkan 34 pasien PP rawat jalan di Poliklinik Saraf CVBC RSUP Prof. Dr. R. D. Kandou Manado pada bulan September 2025. Teknik pengambilan sampel menggunakan consecutive sampling dengan menggunakan kuesioner Pittsburgh Sleep Quality Index (PSQI), data rekam medik, dan dianalisis menggunakan uji chi-square. Hasil penelitian mendapatkan dari 34 pasien, 18 pasien menggunakan dopamin agonis dan 16 pasien tidak. Sebanyak 72,2% pasien pengguna dopamin agonis memiliki kualitas tidur baik, sedangkan pada kelompok non-pengguna hanya 25%. Terdapat hubungan bermakna antara penggunaan dopamin agonis dan kualitas tidur (p=0,006); dan antara variabel usia dan kualitas tidur (p=0,010). Jenis kelamin, komorbiditas, dan lama menderita tidak menunjukkan hubungan bermakna. Simpulan penelitian ialah terdapat hubungan bermakna antara penggunaan dopamin agonis dengan kualitas tidur pada pasien penyakit Parkinson. Pasien penyakit Parkinson yang menggunakan dopamin agonis memiliki kualitas tidur yang lebih baik dibandingkan pasien yang tidak menggunakan.
Kata kunci: penyakit Parkinson; dopamin agonis; kualitas tidur; simtom nonmotorik
References
1. Salim S, Ahmad F, Banu A, Mohammad F. Gut microbiome and Parkinson’s disease: Perspective on pathogenesis and treatment. J Adv Res. 2022;50:135-50. Doi: https://doi.org/10.1016/j.jare.2022.10.013
2. Raza C, Anjum R, Shakeel N ul A. Parkinson’s disease: Mechanisms, translational models and management strategies. Life Sciences. 2019;226:77-90. Doi: https://doi.org/10.1016/j.lfs.2019.03.057
3. Kirani R, Putri PH, Sjahriani T, Fitriyani F. Gambaran karakteristik demografi pasien Parkinson di Rumah Sakit Pertamina Bintang Amin periode 2022-2024. Jurnal Ilmu Kedokteran dan Kesehatan. 2025;12(6):1167–74. Doi: https://doi.org/10.33024/jikk.v12i6.19674
4. Zein IS, Khairunnisa K. Parkinson disease. Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE). 2023;2(2):50-63. Doi: https://doi.org/10.55606/jurrike.v2i2.1701
5. Liu Y, Lu T, Liu J, Wang T, Xu H, Zhou M. Sleep disorders in patients with Parkinson’s disease: a systematic review and meta-analysis. Front Aging Neurosci. 2021;13:700799. Doi: https://doi.org/10.3389/fnagi.2021.700799
6. Perhimpunan Dokter Spesialis Saraf Indonesia (PERDOSSI). Panduan Tatalaksana Penyakit Parkinson di Indonesia Edisi 2024. Jakarta: PERDOSSI; 2024.
7. Chahine LM, Amara AW, Videnovic A. A systematic review of the literature on disorders of sleep and wakefulness in Parkinson’s disease from 2005 to 2015. Sleep Med Rev. 2017;35:33–50. Doi: https://doi.org/10.1016/j.smrv.2016.08.001
8. Si TL, Wang YY, Li JX, Bai W, Sun HL, Rao SY, et al. Poor sleep quality among patients with Parkinson’s disease: a meta-analysis and systematic review. Frontiers in Psychiatry. 2025;16:1606743. Doi: https://doi.org/10.3389/fpsyt.2025.1606743
9. Liu Y, Lu T, Liu J, Wang T, Xu H, Zhou M. Sleep disorders in patients with Parkinson’s disease: a systematic review and meta-analysis. Front Aging Neurosci. 2021;13:700799. Doi: https://doi.org/10.3389/fnagi.2021.700799
10. Ledda C, Romagnolo A, Covolo A, Imbalzano G, Montanaro E, Rizzone MG, et al. Effects of dopaminergic therapy on sleep quality in fluctuating Parkinson’s disease patients. Journal of Neurology. 2024;271(6):3625–30. Doi: https://doi.org/10.1007/s00415-024-12351-y
11. Hammadi HA, Hameed WA, Fakhri MA, Khazaal HM, Abood FK, Hameed EK, et al. Does Parkinson’s disease affect sleep quality? Ir J Med Sci (1971-). 2024;193(4):2035–9. Doi: https://doi.org/10.1007/ s11845-024-03689-3
12. Mahale R, Yadav R, Pal PKr. Does gender differences have a role in determining sleep quality in Parkinson’s disease? Acta Neurologica Belgica. 2020. Doi: https://doi.org/10.1007/s13760-020-01498-w
13. Kang KW, Choi SM, Kim BC. Gender differences in motor and non-motor symptoms in early Parkinson disease. Medicine. 2022;101(3):e28643. Doi: https://doi.org/10.1097/md.0000000000028643
14. Pezzini JV, Trevisan DD, Henrique V, Gauer LE, Lima MMS. Sleep quality in Parkinson disease: clinical insights and PSQI reliability assessment. Sleep Sci. 2024;18(02):e147–54. Doi: https://doi.org/10.1055/s-0044-1791235
15. Wang YJ, Wang X, Li XM. The effect of pramipexole combined with rTMS on sleep disorders in Parkinson’s disease patients. Journal of Neurology and Experimental Neuroscience. 2021;7(1):28–32. Doi: https://doi.org/10.17756/jnen.2021-084
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