UJI AKTIVITAS ANTIINFLAMASI DAN ANTIBAKTER KRIM MINYAK ATSIRI DAUN ROSEMARY (Rosemarinus officinalis L

Abstract

Rosemary leaves contain essential oil compounds that have antibacterial and anti-inflammatory activities. The main components of essential oils are α-pinene, 1,8-cineole, camphene, kmafer, sabinene, bornyl acetate linalool. The cream formulation was chosen because of its more practical use. This study aims to obtain a formula for a rosemary leaf essential oil cream preparation as a treatment for rabbit back skin infections and antibacterial activity against Staphylococcus aureus. Isolation of essential oils was obtained using the water distillation extraction method. Anti-inflammatory activity testing was carried out by infecting the injured rabbit back skin and giving Staphylococcus aureus bacteria. After 24 hours, they were treated with rosemary leaf essential oil cream with concentrations of 5%, 10%, and 15%. The diffusion method was used to test the antibacterial activity of rosemary leaf essential oil cream. The results showed that the antibacterial activity of rosemary leaf essential oil cream was characterized by the formation of inhibition zones around the wells. Anti-inflammatory testing on rabbit backs showed that rosemary leaf essential oil cream with a concentration of 15% had more effective anti-inflammatory activity than concentrations of 5% and 10%.