PENGARUH EKSTRAK ETANOL BUAH KETUMBAR (Coriandrum sativum L.) TERHADAP PENURUNAN KADAR GULA DARAH TIKUS PUTIH YANG DIINDUKSI ALOKSAN
DOI:
https://doi.org/10.35799/pha.3.2014.5417Abstract
ABSTRACTCoriander fruit (Coriandrum sativum L.) has been used and exploited by native people as
drugs to decrease blood sugar levels. The aim of this study was to examine the ability of
ethanol extract of the Coriander fruit (Coriandrum sativum L.) to decrease blood sugar levels
of alloxan-induced rats. This study was used 15 white male rats which induced with alloxan
solution intravenously at dose 130mg/KgBW and divided into 5 groups, which were positive
control (glibenclamide 1:26 mg/kg), negative control (CMC 0.5%), and treatment groups
(fruit extract dose coriander 0:09 g/KgBW, 12:18 g/KgBW, 12:36 g/kg). The treatments were
done on day 7, after the rats had been induced by alloxan, and the blood sugar measurements
were done on day 7, day 11 and day 15 after treatments were given. The percentage of blood
sugar levels decreasing of rats were analyzed by Oneway ANOVA test and Duncan test (α =
0.05 level). Results of statistical analysis shows that there are significant differences between
the dose of coriander friut extracts and negative control, and there are no significant
differences between the dose of coriander fruit extracts 12:09 g/KgBW, 12:18 g/KgBW,
12:36 g/KgBW and positive control.
Key words : Blood Sugar Levels, alloxan, White Male Rats Wistar, Coriandrum sativum L.
ABSTRAK
Buah ketumbar (Coriandrum sativum L.) sejak lama digunakan dan dimanfaatkan oleh
manusia sebagai obat untuk menurunkan kadar gula darah. Penelitian ini bertujuan untuk
menguji ekstrak etanol buah ketumbar (Coriandrum sativum L.) terhadap penurunan kadar
gula darah tikus putih yang diinduksi aloksan. Penelitian ini menggunakan 15 ekor tikus putih
jantan yang diinduksi dengan larutan aloksan dengan dosis 130mg/KgBB secara intravena
dan dibagi menjadi 5 kelompok perlakuan yaitu kontrol positif glibenklamid 1.26 mg/KgBB,
kontrol negatif CMC 0.5%, kelompok perlakuan ekstrak buah ketumbar dosis 0.09 g/KgBB,
0.18 g/KgBB, 0.36 g/KgBB. Pemberian perlakuan dilakukan setelah 7 hari diinduksi aloksan
dan pengukuran kadar gula darah dilakukan pada hari ke-7, hari ke-11 dan hari ke-15 setelah
diberikan perlakuan. Persentase penurunan kadar gula darah tikus dianalisis dengan uji
Oneway ANOVA dan uji Duncan (α = 0.05). Hasil analisa statistik menunjukan bahwa
terdapat perbedaan bermakna antara ekstrak etanol dengan kontrol negatif dan tidak ada
perbedaan yang bermakna antara ekstrak buah ketumbar dosis 0.09 g/KgBB, 0.18 g/KgBB,
0.36 g/KgBB dengan kontrol positif yang berarti ekstrak etanol buah ketumbar mempunyai
efek yang sama dengan kontrol positif.
Kata kunci : Kadar Gula Darah, Aloksan, Tikus Putih Jantan Galur Wistar, Coriandrum
sativum L.
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How to Cite
Umbu Sogara, P. P. (2014). PENGARUH EKSTRAK ETANOL BUAH KETUMBAR (Coriandrum sativum L.) TERHADAP PENURUNAN KADAR GULA DARAH TIKUS PUTIH YANG DIINDUKSI ALOKSAN. PHARMACON, 3(3). https://doi.org/10.35799/pha.3.2014.5417
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