Senyawa Katekin (Flavonoid) dari Kulit Batang Chisocheton balancae C.DC (Meliaceae)

Dewa G Katja, Sisilia A Mantiri, Max R.J Runtuwene, Unang Supratman, Erina Hilmayanti

Abstract


Senyawa katekin (flavonoid) dengan rumus molekul C15H14O6  telah diisolasi dari kulit batang chisocheton balancae C.DC (Meliacea). Penelitian ini bertujuan untuk mendapatkan senyawa katekin (flavonoid). Sampel dimaserasi dengan metanol dan dipartisi dengan pelarut etil asetat. Hasil partisi etil asetat dipisahkan dengan teknik kromatografi dan dihasilkan isolat murni berupa kristal berwarna putih (5,5 mg) dengan titik leleh 175-1770C dengan serapan maksimum pada panjang gelombang 280,30 nm. Struktur kimia senyawa katekin  diidentifikasi dari  data-data spektroskopi meliputi 1H-NMR, 13C-NMR dan DEPT 1350, serta perbandingan dengan data spektroskopi yang diperoleh dari literatur. Hasilnya menunjukkan bahwa kulit batang Chisocheton balancae C.DC (Meliaceae) merupakan senyawa katekin (flavonoid).

Kata kunci: Chisocheton balancae C.DC; katekin ; meliaceae

 

Catechin Compound (Flavonoid) from Chisocheton balancae C.DC (Meliaceae) Bark

ABSTRACT

A catechin compound (flavonoid) with the molecular formula C15H14O6 has been isolated from  Chisocheton balancae C.DC (Meliacee) bark. This study aims to determine the chemical structure of catechins (flavonoids).  The sample is macerated with methanol and partitioned with ehtyl acetate as solvent. The results of the partitioning of ethyl acetate were separated by chromatographic techniques and pure isolates were produced in the form of white crystals (as much as 5,5 mg) with a melting point of 175-1770C and maximum absorption at a wavelength of 280,30 nm. The chemical structure of catechin compound was identified on the basis of spectroscopic data including 1H-NMR, 13C-NMR and DEFT 1350 as well as comparison with spectroscopic data obtained from the literature. The results shows that the bark of  Chisocheton balancae C.DC (Meliaceae) contained catechin compound.

Keywords: Catechin; meliaceae; Chisocheton balancae C.DC


Full Text:

PDF

References


Awang, K., Chong, L., Marthi, M.T., Mokhtar, R.M., Chan, G., Litaudon, M., Gueritte, F., & Mohamad, K. 2012. Malayanines A and B, two novel limonoids from Chisocheton erythrocarpus Hiern, Tetrahedron Letters, 53: 5355-5359.

Heyne. 1987. Tumbuhan Berguna Indonesia Jilid II. Terjemahan Badan Litbang Kehutanan Jakarta. Yayasan Sarana Warna Jaya, Jakarta.

Inada, A., Sukemawa, M., Murata, H., Nakanishi, T., Tokuda, H., Nishino, H., Iwashima, Darnaedi, D., & Murata, J. 1993. Phytochemical studies on Maleaceous Plant. Part VII. Structures and Inhibitory Effects on Epstein-Barr Virus Activation of Triterpenoida from leaves of Chisocheton macrophyllus King. Chem. Pharm. Bull., 41(3): 617-619.

Katja, D.G., Sonda, A.A., Harneti, D., Mayanti, T., & Supratman, U. 2015. 7-Hidroksi-6-Metoksi Kumarin (Skopoletin) dari Kulit Batang Chisocheton celebius (Meliaceae). Jurnal Kimia, 9: 1-4.

Katja, D.G., Farabi, K., Nurlelasari, Harneti, D., Mayanti, T., Supratman, U., Awang, K., & Hayashi, H. 2017. Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae). Journal of Asian Natural Products Research, 19: 194–200.

Lim, C.S. 2008. Chemical Constituents of Chisocheton erythrocarpus hiern. Department of Chemistry Faculty of Science University, Malaya.

Mohammad, K., Hirasawa, Y., Litaudon, M., Awang, K., Hadi, A.H.A., Takeya, K. Ekasari, K., Widyawaruyanti, A., Zaini, N.C., & Morita, H. 2009. Ceramicines B-D new antiplasmodium limonoids from Chisocheton ceramicus. Bioorganic and Medicinal Chemistry, 17: 727-730.

Mohamad, K., Hirasawa, Y., Lim, C.S., Awang, K., Hamid, A., Hadi, A., Takeya, K., & Morita, H. 2008. Ceramicines A and walsogyne A, novel limonoids from two species of Meliaceae. Tetrahedron Letters, 49: 4276-4278.

Najmuldeen, I.A., Ibrahim, A., Tasyriq, M., Lionel, L.A.I., Mohamad, K., Awang, K., & Hasima, N. 2012. 7α-hidroxy-β-sitosterol from Chisocheton tomentosus Induces Apoptosis via Dysregulation of Cellular Bax/Bcl-2 Ratio and Cell Cycle Arrest by Downregulating ERK1/2 Activation. Volume 2012. Article ID 765316, 12 pages. DOI: 10.1155/2012/765316.

Nurlelasari, Muflihah L.F., Wardoyo M.M., Harneti D., & Awang K. 2014. Senyawa 7-Hidroksi-6-Metoksi Kumarin yang bersifat Sitotoksik dari kulit batang Chisocheton macrophyllus. Bionatural-Jurnal Ilmu-ilmu Hayati dan Fisik, 16: 69-72.

Phongmaykin, Kumamoto, Ishikawa, Suttisri, & Saifah. 2008. A new sesquiterpene and other terpenoid constituents of Chisocheton penduliflorus. Archives of pharmacal research, 31: 21–27.

Supratman, U., Naibaho, W., Salam, S., Maharani, L., Hidayat, A.C., Harneti, D., Nurlelasari, & Shiono, Y. 2019. Cytotoxic triterpenoids from the bark of Chisocheton patens Blume (Meliaceae). Phytochemistry Letters, 30: 81-87.

Supriatno, Hidayat, A.T., Farabi, K., Abdullah, F.F., Nurlelasari, Herlina, T., Supratman, U., & Awang, K. 2017. Flavonoid from the stembark of Chisocheton pentandrus (Meliaceae). Jurnal Kimia Valensi, 3:122-126.

Vossen, V.D.H.A.M., & Umali, B.E. (Editors). 2002. Plant resources of south-east Asia No. 14 vegetable oils and fats, Prosea Foundation, Bogor, Indonesia. 150.

Wang, T.Y., Li, Q., & Bi, K.S. 2018. Bioactive Flavonoids in Medicinal Plants: Structure, activity and biological fate. Asian Journal of Pharmaceutical Sciences, 13:12-23.

Wong, C.P., Shimada, M., Nagakura, Y., Nugroho, A.E., Hirasawa, Y., Kaneda, T., Awang, K., Hamid, A., Hadi, A., Mohamad, K., Shio, M., & Morita, H. 2011. Ceramicines E-I, New imonoids from Chisocheton ceramicus. Chem. Frm Bull, 59:407-411.

Wong, C.P., Kaneda, T., Hamid, A., Hadi, A., & Morita, H. 2014. Ceramicine B. a limonoid with anti-lipid droplets accumulation activity from Chisocheton ceramicus. J. Nat Med., 68(1):22-30. DOI: 10.1007/s11418-013-0755-2.

Yang, M.H., Wang, J.S., Luo, J.G., Wang, X.B., and Kong, L.Y. 2009. Tetranortriterpenoids from Chisocheton paniculatus. J. Prod., 72: 2014-2018.




DOI: https://doi.org/10.35799/jis.v21i2.35777

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

         

      

My Visitors:

COPYRIGHT NOTICE: Copyright Holder in Jurnal Ilmias Sains is The Author

LICENSE: (CC-BY-NC)