Evaluasi Shear Wave Elastography, Fibroscan dan Kecepatan Aliran Vena Porta pada Pasien Non-Alcoholic Fatty Liver Disease

Abstract

Absract: This research aims to investigate the congruity between the Shear Wave Elastography, Fibroscan and changes in the portal vein flow velocity in non-alcoholic fatty liver disease patients.The research used was a cross-sectional study method. The research was conducted in the Radiology Section of Dr. Wahidin Sudirohusodo, Makassar from July to December 2020. The research populations were all patients with the clinical non-alcoholic fatty liver and fulfilled the inclusive and exclusive criteria. On the research samples, the Shear Wave Elastography and hepatic hemodynamics were examined using transabdominal ultrasonography, continued by determining the fibrosis degree based on Transient Elastography. Data were analyzed statistically through the Spearman’s correlation test, it was stated congruent if the P value was <0.05.The research involved 32 people, with the gender of 19 males (59.4%) with the range of 46-55 years old (31.3%) of the non-alcoholic fatty liver patients. Based on bivariate analysis, the research result indicates that there is no correlation between mean portal vein velocity and degree of fibrosis with Fibroscan and Shear Wave Elastography. The fibrosis degree with Shear Wave Elastography has a strong correlation (p = 0.001, r = 0.672) with the fibrosis degree based on the Fibroscan.

Key words: Non-alcoholic fatty liver; Shear Wave Elastography; Transient Elastography

Abstrak: Penelitian ini bertujuan mengetahui kesesuaian antara Shear Wave Elastography, Fibroscan dan perubahan kecepatan aliran vena porta pada pasien non-alcoholic fatty liver disease. Metode penelitian yang digunakan adalah kajian potong lintang. Penelitian dilaksanakan di Bagian Radiologi RS Dr. Wahidin Sudirohusodo, Makassar pada Juli sampai dengan Desember 2020. Populasi penelitian ini adalah semua pasien dengan klinis non-alcoholic fatty liver dan memenuhi kriteria inklusi dan ekslusi. Pada sampel penelitian ini dilakukan pemeriksaan Shear Wave Elastography dan hemodinamik hepar dengan ultrasonografi transabdominal, dilanjutkan dengan penentuan derajat fibrosis berdasarkan Transient Elastography. Data dianalisis secara statistik melalui uji korelasi Spearman dikatakan sesuai jika nilai P<0,05. Penelitian ini melibatkan sebanyak 32 orang, dengan jenis kelamin laki-laki 19 (59,4%) orang  dengan rentang usia terbanyak 46-55 (31,3%) tahun pada pasien non-alcoholic fatty liver. Hasil penelitian menunjukkan tidak didapatkan korelasi antara mean kecepatan vena porta dengan derajat fibrosis dengan Fibroscan dan Shear Wave Elastography. Pada derajat fibrosis dengan Shear Wave Elastography mempunyai korelasi kuat (p=0,001, r=0,672) dengan derajat fibrosis berdasarkan Fibroscan.

Kata kunci: Non-alcoholic fatty liver; Shear Wave Elastography; Transient Elastography