Gambaran Kadar Kreatinin Serum dan Estimasi Laju Filtrasi Glomerulus (eLFG) pada Wanita Hamil Normal

Abstract

Abstract: Creatinine is the end result of the metabolism of muscle creatine phosphate which was synthesized in the kidney. Serum creatinine level can normally decrease during pregnancy due to hyperfiltation of the renal glomeruli. Estimation of glomerular filtration rate (GFR) with CKD-EPI formula is beneficially used in populations with GFR >60 ml/min/1.73m2 especially in pregnant women. The creatinine levels of normal pregnant women are lower than of non-pregnant women and pregnant women with pre-eclampsia. This study was aimed to obtain the serum creatinine level and estimated GFR (eGFR) in normal pregnant women. This was a descriptive observational study with a cross sectional design. Samples were obtained by using non-probability sampling of purposive sampling method. Blood samples of 30 normal pregnant women were obtained at three Public Health Centers (Minanga, Sario, and Bahu Manado) from October to November 2017. The laboratory examinations revealed that all samples (100%) showed decreased serum creatinine levels with a mean of 0.53 mg/dL and increased eGRF >90 ml/min/1.73m2. Conclusion: During pregnancy, there was an increase in eGFR and a decrease in serum creatinine level in all trimesters.

Keywords: normal pregnant women, serum creatinine, eGFR

Abstrak: Kreatinin merupakan hasil akhir metabolisme dari kreatin fosfat otot, yang awalnya disintesis di ginjal. Pemeriksaan kreatinin sering digunakan untuk mengetahui fungsi ginjal. Kadar kreatinin serum normalnya dapat menurun selama kehamilan karena terjadi hiperfiltasi glomerulus ginjal. Estimasi Laju Filtrasi Glomerulus (eLFG) dengan formula CKD-EPI lebih baik digunakan pada populasi dengan laju filtrasi glomerulus >60 ml/min/1,73m2 khususnya wanita hamil. Kadar kreatinin wanita hamil normal lebih rendah daripada wanita tidak hamil dan wanita hamil dengan pre-eklampsi. Penelitian ini bertujuan untuk mengetahui gamabaran kreatinin serum dan eLFG pada wanita hamil normal. Jenis penelitian ialah deskriptif observasional dengan desain potong lintang. Sampel diambil dengan cara non-probability sampling jenis purposive sampling. Sampel penelitian ialah sampel darah dari 30 wanita hamil normal yang memeriksakan diri di Puskesmas Minanga, Sario, dan Bahu selama bulan Oktober-November 2017. Berdasarkan hasil pemeriksaan laboratorium didapatkan 30 orang (100%) wanita hamil normal mengalami penurunan kreatinin dengan rerata 0,53 mg/dL dan peningkatan laju filtrasi glomerulus dengan nilai eLFG >90 ml/min/1,73m2. Simpulan: Selama kehamilan terjadi peningkatan eLFG dan penurunan kreatinin serum pada semua trimester.

Kata kunci: wanita hamil normal, kreatinin serum, eLFG