PENGARUH BASIS SALEP TERHADAP FORMULASI SEDIAAN SALEP EKSTRAK DAUN KEMANGI ( Ocimum sanctum L.) PADA KULIT PUNGGUNG KELINCI YANG DIBUAT INFEKSI Staphylococcus aureus

Abstract

The basil plant (Ocimum sanctum L.) contains alkaloids, triterpenoids, flavonoids are able to
provide an antibacterial effect.The aims of this research were to study ointment base effect
against physical properties and antibacterial effect of basil leaf extract ointment on Rabbits
(Oryctolagus cuniculus) back skin infected with staphylococcus aureus.Extraction was done
by soxhlet extraction using ethanol 95% as solvent.Observation of healing time was done by
observing infectionhealingtime on rabbits back skin after anointment treatment, which based
onthe disappearance oferythema and pus. The result shows differences ointment base effected
on the physical properties of an ointment which include shape, color, pH, and dispersive
power, but had no effect on the smell and homogeneity of the preparation. Basil leaves
extract ointment with base type hydrocarbons provide healing infections more quickly,
followed by the type of water-soluble base, absorption, and washable base.
Keywords: Base ointment, basil (Ocimum sanctum L.), Staphylococcus aureus, rabbit