UJI EFEK ANTIINFLAMASI EKSTRAK ETANOL DAUN SUJI (Dracaena angustifolia Roxb) TERHADAP EDEMA KAKI TIKUS PUTIH JANTAN GALUR WISTAR

Abstract

ABSTRACT
Suji (Dracaena angustifolia Roxb.) has been used empirically by the people of North
Sulawesi to cure the disease. Flavonoids and steroids in suji leaves suspected to have
antiinflammatroy effects. This study aims to examine the antiinflammatory effects of ethanol
extract from suji leaves (Dracaena angustifolia Roxb.) on edema of white males wistar foot
induced with 5% white egg solution, and to determine an effective dose of extract to decrease
the edema volume ofrat foot. The test was done using rat hind paw edema or esthablished an
artificial inflammation in left foot of white male rats.The treatments were carried out on five
groups, the positive control group was administered with diclofenac sodium, the negative
control group was administered with aquadest, and the extract groups were administered with
100 mg/KgBB, 300 mg/KgBB and 1000 mg/KgBB of suji leaf extract. Edema volume were
measured every hour for 7 hours using a glass tube. The average of edema volume (mL) and
time (hour) was plotted in a curve to form Area Under Curve (AUC). The AUC values were
used to calculate the percentage of antiinflammatory on each group compared to the negative
control group. Obtained data were analyzed by one-way ANOVA followed by LSD test with
confident level was 0,05. The result of this study indicate that suji leaf can reduce edema
volume of rat foot that induced with 5% white egg solution and antiinflamatory of ethanol
extract from suji leaf 100 mg/KgBB by 33,19 %, 300 mg/KgBB by 14,04 % and 1000
mg/KgBB by 5,80 %.
Keywords: Suji(Dracaena angustifolia Roxb.), antiinflammatory, edema