FORMULASI SALEP EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) dan UJI EFEKTIVITAS TERHADAP PENYEMBUHAN LUKA TERBUKA PADA KELINCI

Abstract

ABSTRACT
Jackfruit leaves is a plant that work as medicine on healing process of skin diseases,
especially in wounds. The purpose of this study is to determine the quality of ointment from
ethanolic extract of Jackfruit leaves at the concentration on 5%, 10% and 15% and the effect
of the open wound healing in rabbits. Type of this research is laboratory experimental. In this
research maceration was done as the extraction method to got the extract of Jackfruit leaves.
The ointment of ethanolic extract from jackfruit leaves made within 3 concentrations of 5%,
10% and 15%. On the testing ointment using organoleptic test, homogenity test and pH test.
The effectiveness assay to heal the open wounds using 5 groups, Betadine ointment (positive
control), basic ointment (negative control), the ointment of ethanolic extract from Jackfruit
leaves 5%, 10%, and 15% of the 3 rabbits with a 1.5 cm was done and observed until 7 days.
The data were processed statistically using One Way ANOVA (Analysis Of Variant) and
followed by LSD (Least Significant Different). Results of this study showed that the ointment
of ethanolic extract from Jackfruit leaves on the concentration of 5%, 10% and 15% produce
qualified ointment of organoleptic test, homogenity test and pH test, also give the effect of
open wound healing in rabbits and the most effective cure is the ointment of ethanolic extract
from Jackfruit leaves 15%.
Keywords: ethanolic extract of Jackfruit leaves, ointment, wound, rabbit.