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REVIEW AKTIVITAS ANTIHIPERTENSI TANAMAN CARICA PAPAYA
Abstract
Kardiovaskular adalah Penyakit tidak menular yang menyerang masyarakat di negara maju hingga negara berkembang seperti Indonesia, salah satu dari penyakit kardiovaskular adalah hipertensi yang disebut sebagai penyumbang kematian terbanyak di dunia setiap tahunnya, seorang dengan tekanan darah abnormal dapat mengalami beberapa penyakit seperti gagal jantung, gagal ginjal, diabetes dan stroke. Tujuan dari penelitian ini untuk mengetahui potensi Carica Papaya dalam penanganan hipertensi dan perkembangan penelitian terhadap potensi Carica Papaya. Subjek review ini adalah artikel nasional dan internasional yang terindeks secara nasional dan international 10 tahun terakhir yang membahas kemampuan antihipertensi pada Carica Papaya dengan melakukan klasifikasi berdasarkan metode pengujian yang digunakan, mekanisme kerja senyawa kimia yang berperan aktif dalam aktivitas hipotensi dan bagian tumbuhan yang digunakan dalam pengujian. Pada studi literatur didapatkan bahwa Carica Papaya memiliki berbagai mineral dan metabolit sekunder yang mampu menurunkan tekanan darah melalu mekanisme yang mirip dengan obat konvensional, Carica Papaya memiliki senyawa saponin, alkaloid, flavonoid dan kalium yang mampu menurunkan tekanan darah dengan mekanisme vasodilatasi, ACE Inhibitor dan diuretik. Carica Papaya memiliki kemampuan antihipertensi yang baik pada seluruh bagian tumbuhan namun perlunya studi lebih lanjut secara spesifik pada senyawa aktif dan mekanisme kerja yang belum diteliti.
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Akhila, S. and Vijayalakshmi, N.G. (2015) “Phytochemical Studies On Carica Papaya Leaf Juice,” International Journal of Pharmaceutical Sciences and Research, 6(2), p. 880. Available at: https://doi.org/10.13040/IJPSR.0975-8232.6(2).880-83.
Akmarawita Kadir (2016) “Hubungan Patofisiologi Hipertensi Dan Hipertensi Renal,” lmiah Kedokteran, 5(1), pp. 15–23.
Anas, Y. and Naimi Hatimah Amalia (2018) “Efek Antihipertensi Ekstrak Etanol Kombinasi Rambut dan Biji Jagung (Zea mays L.) pada Tikus Hipertensi yang Diinduksi Monosodium Glutamat,” Jurnal Ilmu Farmasi dan Farmasi Klinik (JIFFK), 15(1), pp. 29–36. Available at: www.unwahas.ac.id/publikasiilmiah/index.php/ilmufarmasidanfarmasiklinik.
Artha, C., Mustika, A. and Sulistyawati, S.W. (2017) “Pengaruh Esktrak Daun Singawalang Pengaruh Ekstrak Daun Singawalang terhadap Kadar LDL Tikus Putih Jantan Hiperkolesterolemia,” eJurnal Kedokteran Indonesia, 5(2), pp. 105–109. Available at: https://doi.org/10.23886/ejki.5.7151.
Astutik, P., Wirjatmadi, B. and Adriani, M. (2013) “Peranan kadar nitrit oksida (NO) darah dan asupan lemak pada pasien hipertensi dan tidak hipertensi The role levels of blood nitric oxide (NO) and fat intake in patients with hypertension and non hypertension,” Jurnal Gizi Klinik Indonesia, 10(2).
Brasil, G.A. lexandre et al. (2014) “Antihypertensive effect of Carica papaya via a reduction in ACE activity and improved baroreflex,” Planta medica, 80(17), pp. 1580–1587. Available at: https://doi.org/10.1055/s-0034-1383122.
Carvalho, F.A. and Renner, S.S. (2014) “The phylogeny of the Caricaceae,” Genetics and Genomics of Papaya, pp. 81–92. Available at: https://doi.org/10.1007/978-1-4614-8087-7_5.
Chen, M. et al. (2013) “Protective effects of saponin on a hypertension target organ in spontaneously hypertensive rats,” Experimental and Therapeutic Medicine, 5(2), pp. 429–432. Available at: https://doi.org/10.3892/etm.2012.856.
Duarte, J., Francisco, V. and Perez-Vizcaino, F. (2014) “Modulation of nitric oxide by flavonoids,” Food and Function. Royal Society of Chemistry, pp. 1653–1668. Available at: https://doi.org/10.1039/c4fo00144c.
Elekofehinti, O.O. et al. (2013) “Hypoglycemic, antiperoxidative and antihyperlipidemic effects of saponins from Solanum anguivi Lam. fruits in alloxan-induced diabetic rats,” South African Journal of Botany, 88, pp. 56–61. Available at: https://doi.org/10.1016/j.sajb.2013.04.010.
Elisa, N., Anggoro, A.B. and Indriyanti, E. (2021) “Aktivitas Antihipertensi Ekstrak dan Fraksi-Fraksi Daun Avokad (Persea americana Mill) pada Tikus Jantan dengan Parameter Sistolik dan Diastolik,” Jurnal Ilmiah Sains, 21(2), p. 145. Available at: https://doi.org/10.35799/jis.v21i2.35625.
Hakim, E.M., Sivak, K. v. and Kaukhova, I.E. (2021) “Evaluation of the diuretic effect of crude ethanol and saponin-rich extracts of Herniaria glabra L. in rats,” Journal of Ethnopharmacology, 273. Available at: https://doi.org/10.1016/j.jep.2021.113942.
Hasimun, P., Sulaeman, A. and Maharani, I.D.P. (2020) “Supplementation of Carica papaya Leaves (Carica papaya L.) in Nori preparation Reduced Blood Pressure and Arterial Stiffness on Hypertensive Animal Model,” Journal of Young Pharmacists, 12(1), pp. 63–66. Available at: https://doi.org/10.5530/jyp.2020.12.12.
Ilma Arifa, S. et al. (2017) “Faktor Yang Berhubungan Dengan Kejadian Penyakit Ginjal Kronik Pada Penderita Hipertensi Di Indonesia Factors Associated with Chronic Kidney Disease Incidence among Patients with Hypertension in Indonesia,” Jurnal MKMI, 13(4).
Isnania, Fatimawali and Frenly Wehantouw (2014) “Aktivitas Diuretik Dan Skrining Fitokimia Ekstrak Etanol Biji Pepaya (Carica Papaya L.) Pada Tikus Putih Jantan Galur Wistar (Rattus norvegicus),” PHARMACON Jurnal Ilmiah Farmasi-UNSRAT, 3(3).
James, P.A. et al. (2014) “2014 Evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8),” JAMA - Journal of the American Medical Association. American Medical Association, pp. 507–520. Available at: https://doi.org/10.1001/jama.2013.284427.
Karunamoorthi, K. et al. (2014) “Papaya: A gifted nutraceutical plant - a critical review of recent human health research,” TANG [HUMANITAS MEDICINE], 4(1), pp. 2.1-2.17. Available at: https://doi.org/10.5667/tang.2013.0028.
Kementerian Kesehatan RI (2018) Riset Kesehatan Dasar. Jakarta. Available at: https://kesmas.kemkes.go.id/assets/upload/dir_519d41d8cd98f00/files/Hasil-riskesdas-2018_1274.pdf (Accessed: February 20, 2022).
Mulyasari, I. and Septiar Pontang, G. (2017) “The Correlation Between Fat Intake, Fiber, Potassium, Sodium, And The Frequency Of Consuming Fried Food With Hypertension In Men Aged 40-50 Years Old In Gedanganak Village East Ungaran Semarang Regency,” Jurnal Gizi Dan Kesehatan, 9(Vol 9 No 22 (2017): Jurnal Gizi Dan Kesehatan), pp. 166–177. Available at: http://jurnalgizi.unw.ac.id/index.php/JGK/article/view/204/160 (Accessed: February 22, 2022).
Nafiu, A.B. et al. (2018) “Papaya (Carica papaya L., Pawpaw),” Nonvitamin and Nonmineral Nutritional Supplements, pp. 335–359. Available at: https://doi.org/10.1016/B978-0-12-812491-8.00048-5.
Ojo, O A et al. (2017) “Aqueous Extract Of Carica Papaya Linn Roots Halts Sodium Arsenite-Induced Renal Inflammation Through Inhibiting Adenosine Deaminase, 8-Hydroxy-2′-Deoxyguanosine, C-Reactive Protein And Inducible Nitric Oxide Synthase Activity,” / Ser J Exp Clin Res, 46(4), pp. 323–330. Available at: https://doi.org/10.1515/SJECR20170029.
Puspita Anggraini, Rusdi and Ermita Ibrahim Ilyas (2016) “Kadar Na+, K+, Cl-, Dan Kalsium Total Serum Darah Serta Hubungannya Dengan Tekanan Darah Pada Penderita Hipertensi Puspita Anggraini, Rusdi & Ermita Ibrahim Ilyas,” BIOMA, 12(1), pp. 50–66. Available at: https://doi.org/10.21009/Bioma.
Puspitasari and Puti Nadhirah (2020) “Hubungan Hipertensi Terhadap Kejadian Stroke Association Between Hipertension and Stroke Artikel info Artikel history,” Jurnal Ilmiah Kesehatan Sandi Husada, 12, pp. 922–926. Available at: https://doi.org/10.35816/jiskh.v10i2.435.
Ravikant, T. et al. (2012) “Antihypertensive effect of Ethanolic Extract of Indian Carica papaya l. Root bark (caricaceae) in Renal Artery Occluded Hypertensive Rats,” International Journal of Pharmaceutical and Clinical Research, 4(3), pp. 20–23. Available at: www.ijpcr.com.
Roni, A., Maesaroh, M. and Marliani, L. (2019) “Aktivitas Antibakteri Biji,Kulit Dan Daun Pepaya (Carica Papaya L.) Terhadap Bakteri Escherichia Coli dan Staphylococcus Aureus,” Kartika : Jurnal Ilmiah Farmasi, 6(1), p. 29. Available at: https://doi.org/10.26874/kjif.v6i1.134.
Rustiani, E. and Umi Sa, P. (2020) “Efektivitas Herbal Cair Kombinasi Daun Pepaya dan Kelopak Bunga Rosella Sebagai Antihipertensi Effectiveness of Herbal Liquid Combination of Papaya Leaves Extract and Rosella Flower Petals as Antihypertensive,” Acta Veterinaria Indonesiana, 8(1), pp. 10–17. Available at: http://www.journal.ipb.ac.id/indeks.php/actavetindones.
S Gadge, M.G.V.S. (2020) “Marvelous plant Carica papaya Linn: A herbal therapeutic option,” Phytopathology, 9(4), pp. 629–633. Available at: https://doi.org/10.22271/PHYTO.2020.V9.I4I.11771.
Santana, L.F. et al. (2019) “Nutraceutical potential of carica papaya in metabolic syndrome,” Nutrients, 11(7). Available at: https://doi.org/10.3390/nu11071608.
Suneja, M. and Sanders, M.L. (2017) “Hypertensive Emergency,” Medical Clinics of North America, 101(3), pp. 465–478. Available at: https://doi.org/10.1016/j.mcna.2016.12.007.
Tita Khosima Hidayati, Yasmiwar Susilawati and Ahmad Muhtad (2020) “Kegiatan Farmakologis Dari Berbagai Bagian Carica Papaya Linn. Ekstrak: Buah, Daun, Benih, Uap, Kulit Dan Akar,” Jurnal Riset Kefarmasian Indonesia, 2(3), pp. 211–2026.
Unger, T. et al. (2020) “2020 International Society of Hypertension Global Hypertension Practice Guidelines,” Hypertension, 75(6), pp. 1334–1357. Available at: https://doi.org/10.1161/HYPERTENSIONAHA.120.15026.
Wahdi, A. et al. (2020) “The Effectiveness of Giving Papaya Fruit (Carica Papaya) Toward Blood Pressure on Elderly Hypertension Patients,” IOP Conference Series: Earth and Environmental Science, 519(1). Available at: https://doi.org/10.1088/1755-1315/519/1/012007.
Y.Adam et al. (2013) “Diuretic Activity of Roots from Carica papaya L. and Ananas comosus L.,” International Journal of Pharmaceutical Sciences Review and Research, Res., 23(1),(no 32), pp. 163–167. Available at: https://www.researchgate.net/profile/Zuraini-Ahmad/publication/258566298_Diuretic_Activity_of_Roots_from_Carica_papaya_L_and_Ananas_comosus_L/links/00b7d528ab8b0e4842000000/Diuretic-Activity-of-Roots-from-Carica-papaya-L-and-Ananas-comosus-L.pdf (Accessed: February 20, 2022).
Yogiraj, V. et al. (2014) “Carica papaya Linn: An Overview,” International Journal of Herbal Medicine, 2(5), pp. 1–8.
DOI: https://doi.org/10.35799/pha.11.2022.41769
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