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UJI EFEK ANTIINFLAMASI EKSTRAK ETANOL KULIT BATANG JAMBU BIJI (PSIDIUM GUAJAVA) TERHADAP EDEMA KAKI TIKUS JANTAN GALUR WISTAR
Abstract
Inflamation is a protective response of body from injury of cell. Edema is one of
inflammation sign. Guava stem leather contains of flavonoid which has potency to inhibit
edema. The aims of this research were to study antiinflamation effect of ethanolic extract
ofguava stem leather (Psidium guajava L.) on edema of white mice strain wistar legs.The
subjects in this research were 25 wistar male which divided into 5 groups, namely negative
control (aquades), positive control (indometasin) and extract group with concentration 1%,
2% and 4%. Every group consists of five mices. Aquades, indometasin and extract
supplementation were done per oral, followed with 5% of white egg induction on mice left
leglead to edema formation.Measurement of edema volume was done using plestimometer,
and observation of edema were made every hour during 7 hours. Data which obtained were
analyzed with ANOVA, if there is a differences between treatment, analysis continue to LSD
test. The result shows that supplementation of ethanolic extract of guava stem leather
concentration 1% and 2 % decrease edema significantly with percent of inhibition 37,37 and
32,59%, but supplementation of ethanolic extract of guava stem leather concentration 1% did
not shows inhibition effect .
Keywords: guava stem leather, antiinflamation, edema
inflammation sign. Guava stem leather contains of flavonoid which has potency to inhibit
edema. The aims of this research were to study antiinflamation effect of ethanolic extract
ofguava stem leather (Psidium guajava L.) on edema of white mice strain wistar legs.The
subjects in this research were 25 wistar male which divided into 5 groups, namely negative
control (aquades), positive control (indometasin) and extract group with concentration 1%,
2% and 4%. Every group consists of five mices. Aquades, indometasin and extract
supplementation were done per oral, followed with 5% of white egg induction on mice left
leglead to edema formation.Measurement of edema volume was done using plestimometer,
and observation of edema were made every hour during 7 hours. Data which obtained were
analyzed with ANOVA, if there is a differences between treatment, analysis continue to LSD
test. The result shows that supplementation of ethanolic extract of guava stem leather
concentration 1% and 2 % decrease edema significantly with percent of inhibition 37,37 and
32,59%, but supplementation of ethanolic extract of guava stem leather concentration 1% did
not shows inhibition effect .
Keywords: guava stem leather, antiinflamation, edema
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PDFDOI: https://doi.org/10.35799/pha.1.2012.508
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