Pengaruh Jus Buah Apel Merah (Pyrus malus L.) Terhadap Kadar Kolesterol HDL (High Density Lipoprotein) Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus)

Abstract

The aims of this research were to study the effect of red apple juice (Pyrus malus L.)
on Blood HDL cholesterol (High Density Lipoprotein) of white male mice strain wistar
(Rattus norvegicus).This research using experimental method,and Pre and Post test
Randomized Controlled Group Design. The subjects in these research were 25 mices, which
possess 180-200g weight. Mices were divided into 5 groups, namely negative control
(aquadest), positive control (Simvastatin) and Pyrus malus juice treatments concentration 2
ml per day treatment (P1), 4 ml/day treatment (P2) and 8 ml/day treatment (P3). Every group
consists of five mices.Treatment starts by feds mices with high content of lipids diet for ten
days.At day eleven, all mices were analyzedits HDL cholesterol (pre-test).Thenall mices
were feds with high content of lipids diet and its treatment.After ten days of treatment, posttest
were conducted.Data were analyzed using spss ver.19. The differences between
treatmentswere analyzed usingone way ANOVA. The results shows that 8 ml/day Pyrus
malus juice significantly increase HDL cholesterol of white male wistar(p<0,05). Pyrus
malus juice(P3)possess activity as simvastatin.
Keywords: Pyrus malus L., Rattus norvegicus L., HDL cholesterol