AKTIVITAS ANTIKANKER SENYAWA PTEROKARPAN DARI Erythrina fusca L.

Abstract

AKTIVITAS ANTIKANKER SENYAWA PTEROKARPAN DARI Erythrina fusca L.

Novi Anggreini¹⁾, Ratih Dewi Saputri¹⁾, Tjitjik Srie Tjahjandarie¹⁾, Mulyadi Tanjung^1*)

¹⁾Natural Products Chemistry Research Group, Organic Chemistry Division,

Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia

mulyadi-t@fst.unair.ac.id

ABSTRACT

Two pterocarpans  namely as sandwicensin (1)  dan phaseollin (2) were isolated from  the stem bark of. Erythrina fusca L. Their structures were determined  based on spectroscopic data such as UV, IR, MS, 1D and 2D NMR. Compounds 1–2 were evaluated for their anticancer against murin leukemia P-388 cells showing their IC₅₀ were 1.20 and 1.05 µg/ml, respectively and very high activity.

Keywords : Erythrina fusca L., sandwicensin, phaseollin, anticancer

ABSTRAK

Dua senyawa pterokarpan yakni sandwisensin (1)  dan paseollin (2) telah diisolasi dari kulit batang Erythrina fusca L. Struktur senyawa pterokarpan ditetapkan berdasarkan analisis spektroskopi UV, IR, MS, 1D dan 2D NMR. Uji aktivitas antikanker senyawa 1–2 terhadap sel murin leukemia P-388 memperlihatkan IC₅₀ 1,20 dan 1,05 µg/ml yang dikategorikan sangat aktif.

Kata kunci : Erythrina fusca L., sandwisensin, paesolin, antikanker