Efektivitas Terapi Oksigen Hiperbarik pada Nyeri Kronik Osteoartritis Lutut
DOI:
https://doi.org/10.35790/msj.v5i2.46565Abstract
Abstract: Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage degeneration, subchondral bone changes, osteophyte formation, sinovitis or arthritis. The aim of osteoarthritis management is to reduce pain, increase joint function, and decrease disability. Hyperbaric oxygen therapy (HBOT) can inhibit astrocyte activation and inflammatory factor production, and maintain transmission and intergration of sensoric information through dorsal neurons, therefore, resulting in pain reduction. This study aimed to evaluate the effectiveness of HBOT in chronic pain of knee osteoarthritis. This was a parallel, two-arm, placebo-controlled, randomized clinical trial in adults with knee osteoarthritis at two hospitals in Manado, namely Badan Layanan Umum Rumah Sakit Umum Pusat Prof. Dr. R. D. Kandou and Rumah Sakit Siloam. The results obtained 44 patients suffered from knee osteoarthritis grade 1 dan 2 associated with chronic pain as subjects, divided into two groups namely intervention with HBOT and control groups. Determination of normality of numeric variables was performed with Shapiro-Wilk test. The statistic test confirmed that the distribution of VAS scores was relatively not different between before and after HBOT, and the control group (p=0.421 and p=0.634). In conclusion, hyperbaric oxygen therapy can be used to reduce chronic pain in knee osteoarthritis.
Keywords: knee osteoarthritis; hyperbaric oxygen therapy; chronic pain
Abstrak: Osteoartritis (OA) merupakan suatu penyakit sendi degeneratif yang dikarakteristikkan dengan degenerasi kartilago progresif, perubahan tulang subkondral, pembentukan osteofit, dan sinovitis atau inflamasi sendi. Tujuan penatalaksanaan OA ialah untuk meredakan nyeri, meningkatkan fungsi, dan membatasi disabilitas Terapi oksigen hiperbarik (TOHB) dapat menginhibisi aktivasi astrosit dan produksi faktor inflamatorik serta mempertahankan transmisi dan integrasi informasi sensori melalui neuron dorsal sehingga nyeri menurun. Penelitian ini bertujuan untuk menilai efektifitas TOHB dalam penatalaksanaan nyeri kronik pada OA lutut. Penelitian ini didesain sebagai suatu parallel, two-arm, placebo-controlled, randomized clinical trial pada dewasa dengan OA lutut di dua rumah sakit di Manado, Badan Layanan Umum Rumah Sakit Umum Pusat Prof. Dr. R. D. Kandou dan Rumah Sakit Siloam. Sebanyak 44 pasien OA lutut grade 1 dan 2 dengan nyeri kronik menjadi subjek penelitian, yang dibagi secara acak atas dua kelompok: intervensi TOHB dan kontrol. Penentuan normalitas variabel numerik dilakukan menggunakan uji Shapiro-Wilk. Hasil statistik mengonfirmasi distribusi penurunan skor VAS relatif tidak berbeda bermakna sebelum dan setelah TOHB dan kelompok kontrol (p=0,421 dan p=0,634). Simpulan penelitian ini terapi oksigen hiperbarik kemungkinan dapat menurunkan nyeri kronik pada penderita osteoartristis lutut.
Kata kunci: osteoartritis lutut; terapi oksigen hiperbarik; nyeri kronik
References
Litwic A, Edwards MH, Dennison EM, Cooper C. Epidemiology and burden of osteoarthritis. Br Med Bull. 2013;105(1):185–99. Doi: 10.1093/bmb/lds038.
Sutherland AM, Clarke HA, Katz J, Katznelson R. Hyperbaric oxygen therapy: a new treatment for chronic pain? Pain Pract. 2016;16(5):620–8. Doi: 10.1111/papr.12312.
Baskar APM, Kiranmathyi B, Sivaraj C, Saraswathi K. Osteoarthritis: pathophysiology and current treatment modalities. J Drug Deliv Ther. 2019;9(3):661–8. [Online]. Available from: http://dx.doi.org/10.22270/jddt.v9i3.2678.
Mohamed ASE, Abdelrahman AA, Aly UF, Khaled KA. Hyperbaric oxygen therapy: a review. Eur J Clin Pharm. 2018;20(5):263–9.
Johnston BR, Ha AY, Brea B, Liu PY. The mechanism of 70 hyperbaric oxygen therapy in the treatment of chronic wounds and diabetic foot ulcers. R I Med J. 2016;99(2):26–9.
Tanoeisan C. Pengaruh terapi repetitive peripheral magnetic stimulation (Abstrak). J Med Dan Rehabil. 2020;2(2):1–6.
Olex-Zarychta D. Hyperbaric oxygenation as adjunctive therapy in the treatment of sudden sensorineural hearing loss. Int J Mol Sci. 2020;21(22):1–14. Doi: 10.3390/ijms21228588.
Spitaels D, Mamouris P, Vaes B, Smeets M, Luyten F, Hermens R, et al. Epidemiology of knee osteoarthritis in general practice: a registry-based study. BMJ Open. 2020;10(1):e031734. Doi: 10.1136/bmjopen-2019-031734.
Barilaro G, Masala IF, Parracchini R, Iesu C, Caddia G, Sarzi-Puttini P, et al. The role of hyperbaric oxygen therapy in orthopedics and rheumatological diseases. Isr Med Assoc J. 2017;19(7):429-34
Mansbridge J. Skin substitutes to enhance wound healing. Expert Opin Investig Drugs. 1998;7(5):803–9, Doi: 10.1517/13543784.7.5.803.
Racine J, Aaron RK. Pathogenesis and epidemiology of osteoarthriti. R. I. Med. J. 2013;96(3):19–22.
Lespasio MJ, Piuzzi NS, Husni ME, Muschler GF, Guarino A, Mont MA. Knee osteoarthritis: a primer. Perm J. 2017;21:1–7. Doi: 10.7812/TPP/16-183.
Shinomiya N, Asai Y. Hyperbaric Oxygenation Therapy: Molecular Mechanisms and Clinical Applications. Springer Nature; 2019. Doi: https://doi.org/10.1007/978-981-13-7836-2-
Rillo O, Riera H, Acosta C, Liendo V, Bolaños J, Monterola L, et al. PANLAR Consensus Recommendations for the Management in Osteoarthritis of Hand, Hip, and Knee. J Clin Rheumatol. 2016;22(7):345-54. Doi: 10.1097/RHU.0000000000000449.
Yılmaz O, Bilge A, Erken HY, Kuru T. The effects of systemic ozone application and hyperbaric oxygen therapy on knee osteoarthritis: an experimental study in rats. Int Orthop. 2021;45(2):489–96. Doi: 10.1007/s00264-020-04871-9.
Lavigne P, Benderdour M, Shi MQ, Lajeunesse D, Fernandes JC. Involvement of ICAM-1 in bone metabolism: a potential target in the treatment of bone diseases? Expert Opin Biol Ther. 2005;5(3):313–20. Doi: 10.1517/14712598.5.3.313.
Taruc-Uy RL, Lynch SA. Diagnosis and treatment of osteoarthritis. Prim Care Clin Off Pract. 2013;40(4):821–36. Doi: 10.1016/j.pop.2013.08.003.
Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Care Res. 2020;72(2):149–62. Doi: 10.1002/acr.24131.
Lin SS, Yuan LY, Niu CC, Tu YK, Yang CY, Ueng SWN. Hyperbaric oxygen inhibits the HMGB1/RAGE signaling pathway by upregulating Mir-107 expression in human osteoarthritic chondrocytes. Osteoarthr Cartil. 2019;27(9):1372–81. Doi: 10.1016/j.joca.2019.05.011.
Yildiz S, Uzun G, Kiralp Z. Hyperbaric oxygen therapy in chronic pain management. Curr Pain Headache Rep. 2006;10(2):95–100. Doi: 10.1007/s11916-006-0019-x.
Ding Y, Yao P, Hong T, Han Z, Zhao B, Chen W, et al. Early hyperbaric oxygen effects on neuropathic pain and nitric oxide synthase isoforms in CCI rats. Oncotarget. 2018;9(7):7513–21. Doi: 10.18632/oncotarget.23867.
Leung YY, Pua YH, Thumboo J. A perspective on osteoarthritis research in Singapore. Proc. Singapore Healthc. 2013;22(1):31–9. Doi: 10.1177/201010581302200106.
Hawamdeh ZM, Al-ajlouni JM. The clinical pattern of knee osteoarthritis in Jordan : a hospital based study. Int J Med Sci. 2013;10(6):790-5. Doi: 10.7150/ijms.5140.
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