FORMULASI SEDIAAN GEL ANTIJERAWAT MINYAK ATSIRI KULIT BATANG KAYU MANIS (Cinnamomum burmanii) DAN UJI AKTIVITAS TERHADAP BAKTERI Staphylococcus aureus

Authors

  • Sarah H. Pelen

DOI:

https://doi.org/10.35799/pha.5.2016.13984

Abstract

FORMULASI SEDIAAN GEL ANTIJERAWAT MINYAK ATSIRI KULIT BATANG KAYU MANIS (Cinnamomum burmanii) DAN UJI AKTIVITAS TERHADAP BAKTERI Staphylococcus aureus

Sarah Pelen1), Adeanne Wullur1), Gayatri Citraningtyas1)

1)Program Studi Farmasi FMIPA UNSRAT Manado, 95115

ABSTRACT

Acne is a pile of oil glands in the skin that are actively being clogged by dirt and infection because of bacteria Staphylococcus aureus. The bark is cinnamon (Cinnmomum burmanii) contains antibacterial compounds sinamaldehid and eugenol. This research aims to create a gel formulation anti-acne essential oil of cinnamon bark with two variations of the concentration of HPMC base that is 3% and 7% gel also examine the effect of essential oils of cinnamon bark on the antibacterial activity. The research proves that the essential oil of cinnamon bark can be formulated as a gel formulation antijerawat eligible organoleptic, homogeneity, pH, dispersive power and consistency. Gel essential oil of cinnamon bark with concentration of 7% is the most excellent gel inhibits the activity of S. aureus because of inhibition zone of 7,8 mm were included in the category of medium inhibition.

Keywords: cinnamon bark, gel, antijerawat, Staphylococcus aureus

ABSTRAK

Jerawat merupakan timbunan kelenjar minyak pada kulit yang terlalu aktif yang tersumbat oleh kotoran dan terjadi infeksi karena adanya bakteri Staphylococcus aureus. Kulit batang kayu manis (Cinnmomum burmanii) mengandung senyawa antibakteri sinamaldehid dan eugenol. Penelitian ini bertujuan untuk membuat formulasi sediaan gel antijerawat minyak atsiri kulit batang kayu manis dengan dua variasi konsentrasi basis HPMC yakni 3% dan 7% juga menguji pengaruh gel minyak atsiri kulit batang kayu manis terhadap aktivitas antibakteri. Hasil penelitian membuktikan bahwa minyak atsiri kulit batang kayu manis dapat diformulasikan sebagai sediaan gel antijerawat yang memenuhi persyaratan organoleptik, homogenitas, pH, daya sebar dan konsistensi. Gel minyak atsiri kulit batang kayu manis dengan konsentrasi 7% merupakan gel yang paling baik menghambat aktivitas bakteri S. aureus karena memiliki zona hambat 7,8 mm yang termasuk dalam kategori daya hambat sedang.

 

 

Kata kunci: Kulit batang kayu manis, gel, antijerawat, Staphylococcus aureus

 

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Published

2016-10-31

How to Cite

Pelen, S. H. (2016). FORMULASI SEDIAAN GEL ANTIJERAWAT MINYAK ATSIRI KULIT BATANG KAYU MANIS (Cinnamomum burmanii) DAN UJI AKTIVITAS TERHADAP BAKTERI Staphylococcus aureus. PHARMACON, 5(4). https://doi.org/10.35799/pha.5.2016.13984

Issue

Vol. 5 No. 4 (2016): Pharmacon

Section

Articles

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