PENGARUH EKSTRAK ETANOL BUAH PINANG YAKI (Areca vestiaria ) TERHADAP GAMBARAN MAKROSKOPIS ORGAN JANTUNG PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus)

Authors

  • I Dewa A.R. Anggraeni

DOI:

https://doi.org/10.35799/pha.6.2017.16579

Abstract

PENGARUH EKSTRAK ETANOL BUAH  PINANG YAKI (Areca vestiaria ) TERHADAP GAMBARAN MAKROSKOPIS ORGAN  JANTUNG PADA TIKUS PUTIH JANTAN GALUR

WISTAR (Rattus norvegicus)

 

I Dewa Ayu Rake Anggraeni1), Widdhi Bodhi1), Herny Simbala1)

 1)Program Studi Farmasi FMIPA UNSRAT Manado, 95115

 

ABSTRACT

 

Crowshaft palm nuts (Areca vestiaria), from the Arecaceae family, have been used by the people of North Sulawesi for cancer medicine, diabetes, and male contraception.This study aims to see the effect of the consumption of crowshaft palm nuts extract on macroscopic description of cardiac organ in white mouse.The study was conducted using 12 male wistar rats, divided into four groups of doses, administered with ethanol extract of crowshaft palm nutsoraly (7,2 mg/mL, 14,4 mg/mL, 21,6mg/mL), and one group as negative control group for a comparison.The testing period was conducted for 40 days, with observations made in the form of rat body weight, macroscopic observation of cardiac organ and observation of organ weight.The results showed that the administered ofcrowshaft palm nuts extracts did not cause significant changes in macroscopic description of cardiac organ.In the analysis of the research using One Way ANOVA test, the result of the test showed that there was no significant difference in the average of body weight weighing and rat organ weight (p> 0.05).It can be concluded that the ethanol extract of crowshaft palm nutsdid not affect the macroscopic description of cardiac organ.

 

Keywords: Crownshaft palm (Areca vestiaria), cardiac macroscopic, white rat (Rattusnorvegicus)

 

ABSTRAK

 

Pinang yaki (Areca vestiaria) termasuk familia Arecaceae, telah digunakan oleh masyarakat Sulawesi Utara sebagai obat kanker,diabetes, dan kontrasepsi pria.Penelitian ini bertujuan untuk  melihat pengaruh yang ditimbulkan dari konsumsi ekstrak  Pinang yaki terhadap gambaran makroskopis organ jantung pada tikus putih.Penelitian dilakukan menggunakan hewan percobaan  tikus putih jantan galur wistar berjumLah 12 ekor, yang dibagi dalam empat kelompok dosis yang diberi ekstrak etanol buah Pinang yaki secara oral yaitu  (7,2mg/mL, 14,4mg/mL, 21,6mg/mL) dan satu kelompok  kontrol negatif sebagai pembanding. Masa pengujian dilakukan selama 40 hari, dengan pengamatan yang dilakukan berupa pengamatan berat badan tikus, pengamatan makroskopis organ jantung dan pengamatan berat organ. Hasil penelitian menunjukkan bahwa pemberian ektrak buah Pinang yaki tidak menimbulkan perubahan yang signifikan pada gambaran makroskopis organ jantung.Pada analisis penelitian menggunanakan uji One way ANOVA hasil  pengujian tersebut menunjukkan tidak ada perbedaan yang bermakna pada hasil penimbangan rata-rata berat badan dan berat organ jantung tikus (p > 0.05). dapat disimpulkan ekstrak etanol buah Pinang yaki tidak berpengaruh pada gambaran makroskopis organ jantung.

 

Kata Kunci : Pinang yaki (Areca vestiaria), makroskopis jantung, tikus putih (Rattus norvegicus)

 

 

Downloads

Published

2017-07-05

How to Cite

Anggraeni, I. D. A. (2017). PENGARUH EKSTRAK ETANOL BUAH PINANG YAKI (Areca vestiaria ) TERHADAP GAMBARAN MAKROSKOPIS ORGAN JANTUNG PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus). PHARMACON, 6(3). https://doi.org/10.35799/pha.6.2017.16579

Issue

Vol. 6 No. 3 (2017): Pharmacon

Section

Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)