UJI EFEK ANTIINFLAMASI EKSTRAK ETANOL KULIT BUAH MAHKOTA DEWA (Phaleria macrocarpa Boerl.) TERHADAP EDEMA KAKI TIKUS PUTIH JANTAN
DOI:
https://doi.org/10.35799/pha.3.2014.3890Abstrak
This study to prove the ethanol extract of the Mahkota Dewa skin fruit has antiinflammatory effects on foot edema white male rats by induced 5 % solution of white egg and determine ethanol extract dose from Mahkota Dewa Skin Fruit that most effective for decrease the volume of foot edema white male rats induced 5 % solution of white egg . This study used 15 white male rats and divided into 5 groups, negative control group (aquadest), positive control group (natrium diclofenac), treatment group (ethanol extract of Mahkota Dewa Skin Fruit dose 140mg/200gBB , 280mg/200gBB , 420mg/200gBB . after oral gived, the rat foot edema made by induced of a 5% solution of white egg . Rat foot Volumes measured every 1 hour for 7 hours . Based on the results of the study , the ethanol extract of Mahkota Dewa Skin Fruit with a dose 140mg/200gBB have antiinflammatory Effects 16,91 %, 280mg/200gBB by 18.87 % and 420mg/200gBB by 19.09 % and the most effective dose to decrease the volume of foot edema white male rats from ethanol extract of Mahkota Dewa Skin Fruit at doses 420mg/200gBB that have antiinflammatory Effects 19,09 %.
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Key words : Antiinflammatory, edema, Phaleria macrocarpa Boerl
Unduhan
Terbitan
Bagian
Lisensi
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