PENGARUH SUHU TERHADAP STABILITAS BERBAGAI PRODUK TABLET NIFEDIPIN

Authors

  • Elda F Luawo,
  • Gayatri citraningtyas
  • Novel Kojong

DOI:

https://doi.org/10.35799/pha.1.2012.507

Abstract

Drug storage at heat air condition, high humidity room, and exposed with light lead to
drug degradation. Temperature changes is one of external factor cause unstability of
pharmaceutical product.The purpose of this research is to examine the effect of temperature on
nifedipin stability. The method using in this research is factorial Complete Random design.
There are two factors. Factor A is temperature(40oC, 50 oC, and 60 oC) and factor B are period
(60, 120 and 180 minutes). There are three samples in this research research. Analysis of
nifedipin content using Spectrophotometer UV-Vis. Obtained data were analyzed using spss ver.
20. The differences between variable were statistical analyzed. The results shows that sample A
at temperature 60 oC, after 180 minutes treatment decrease to 86,47%, Sample B 86,43%, and
sample C 85,66%, respectively. Temperature significantly effect on the stability of nifedipin
(p<0,05).
Keywords: temperature, stability, Nifedipin

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Published

2012-11-01

How to Cite

Luawo, E. F., citraningtyas, G., & Kojong, N. (2012). PENGARUH SUHU TERHADAP STABILITAS BERBAGAI PRODUK TABLET NIFEDIPIN. PHARMACON, 1(2). https://doi.org/10.35799/pha.1.2012.507

Issue

Vol. 1 No. 2 (2012)

Section

Articles

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