UJI EFEKTIVITAS EKSTRAK KULIT BATANG JAMBU METE (Anacardium Occidentale L.) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) YANG DIINDUKSI ALOKSAN

Authors

  • Fitri Prihartini Carolus

DOI:

https://doi.org/10.35799/pha.3.2014.5418

Abstract

ABSTRACT
Cashew (Anacardium occidentale L.) is one of the plant that used by native people as
diabetics medicin. This research was intended to find out the effectiveness of cashew stem’s
bark extract upon the reduction of blood sugar levels on white male wistar which were
inducted with aloxane. 30 mices were made to being diabetic by aloxan 130 mg/KgBB
intravenously. Then they were devide into 5 treatment groups, they were dose extract 0,085
g/KgBB, dose 0,17 g/KgBB, dose 0,34 g/KgBB, as the comparison of Glibenklamid 0,63
mg/KgBB (positive control) and CMC 0,5 % (negative control) and 5 mices for normal
control. The collected data were analyzed by Duncan test. analyzed Shows that there are
significant difference (α <0.05) between dose of extract and the negative control but nothing
significant difference with positive control. Based on this result, it can be concluded that the
ethanol extract of stem’s bark of Anacardium occidentale L. has effect upon the reduction of
blood sugar levels on white male wistar which are inducted with aloxane.
Key words : cashew stem bark, blood glucose, Rattus norvegicus
ABSTRAK
Jambu mete (Anacardium occidentale L.) merupakan salah satu spesies tumbuhan yang
dimanfaatkan masyarakat sebagai obat untuk penyakit kencing manis. Penelitian ini bertujuan
untuk mengetahui efektivitas ekstrak kulit batang jambu mete terhadap penurunan kadar
glukosa darah pada tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi
aloksan. Sebanyak 30 ekor tikus dibuat diabetes dengan menggunakan aloksan 130 mg/kgBB
secara intravena. Kemudian dibagi menjadi 5 kelompok perlakuan, yaitu: ekstrak dosis 0,085
g/KgBB, dosis0,17 g/KgBB, dosis 0,34 g/KgBB, sebagai pembanding Glibenklamid 0,63
mg/KgBB (control positif) dan CMC 0,5% (control negatif) serta 5 ekor tikus untuk kontrol
normal. Data yang diperoleh dianalisis dengan SPSS ver.20, uji one way ANOVA dan
dilanjutkan dengan uji Duncan. Hasil analisa statistik menunjukkan terdapat perbedaan
penurunan kadar gula darah yang signifikan antara kelompok perlakuan dosis ekstrak dengan
kontrol negatif, tetapi tidak memiliki perbedaan secara signifikan dengan control positif.
Berdasarkan hasil tersebut dapat disimpulkan ekstrak etanol kulit batang Anacardium
occidentale L. memiliki efek terhadap penurunan kadar gula darah tikus putih jantan galur
wistar yang diinduksi aloksan.
Kata kunci : kulit batang jambu mete, gula darah, Rattus norvegicus

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How to Cite

Carolus, F. P. (2014). UJI EFEKTIVITAS EKSTRAK KULIT BATANG JAMBU METE (Anacardium Occidentale L.) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) YANG DIINDUKSI ALOKSAN. PHARMACON, 3(3). https://doi.org/10.35799/pha.3.2014.5418

Issue

Vol. 3 No. 3 (2014)

Section

Articles

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