UJI EFEKTIVITAS EKSTRAK ETANOL RAMBUT JAGUNG (Zea mays L.) TERHADAP PENURUNAN KADAR GULA DARAH TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.) YANG DIINDUKSI ALOKSAN

Authors

  • Kristover Koloay

DOI:

https://doi.org/10.35799/pha.4.2015.8835

Abstract

UJI EFEKTIVITAS EKSTRAK ETANOL RAMBUT JAGUNG (Zea mays L.) TERHADAP PENURUNAN KADAR GULA DARAH TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.) YANG DIINDUKSI ALOKSAN

 

Kristover Koloay1), Gayatri Citraningtyas1),  Widya Astuty Lolo1)

1)Program Studi Farmasi FMIPA UNSRAT Manado, 95115

 

 

ABSTRACT

 

Hair corn (Zea mays L.) is a plant that has been known to lowering blood glucose level, but it has not been proved experimentally. This study aims to test the effectiveness of the ethanol extract of hair corn to lowering blood glucose levels white male rats strain Wistar induced alloxan. This study design is randomized experimental design, using white male rats strain Wistar (Rattus norvegicus L.) were made hyperglycemia using alloxan 130 mg/kgBB intraperitoneally. The sample consisted of 15 rats were divided 5 groups. A positive control group (glibenclamide 0,63 mg/kg), group B as a negative control (aquadest), group C (hair corn extract 0,63 g/KgBW), group D (hair corn extract 1,26 g/kg) and group E (hair corn extract 2,52 g/KgBW). The treatment was given once for two weeks. Data were analyzed using SPSS, significant difference between treatments was tested by one-way ANOVA followed by LSD to see significant differences between each treatment group. The results showed that the hair corn extract has the effect of lowering glucose level and the most effective dose is 2,52 g/KgBW. This study showed that the extract of hair corn (Zea mays L.) has the effect of lowering blood glucose levels in white male rats strain Wistar (Rattus norvegicus L.) induced by alloxan.

 

Key words : Zea mays L., hyperglycemia, alloxan, Rattus norvegicus L.

 

ABSTRAK

 

Rambut jagung (Zea mays L.) merupakan tanaman yang telah diketahui mampu menurunkan kadar gula darah, namun belum dibuktikan secara eksperimental. Penelitian ini bertujuan untuk menguji efektivitas dari ekstrak etanol rambut jagung terhadap penurunan kadar gula darah tikus putih jantan galur wistar yang diinduksi aloksan. Desain penelitian ini adalah eksperimental dengan rancangan acak, menggunakan tikus putih jantan galur wistar (Rattus norvegicus L.) yang dibuat hiperglikemia menggunakan aloksan 130 mg/KgBB secara intraperitoneal. Sampel terdiri dari 15 ekor tikus yang dibagi 5 kelompok. Kelompok A sebagai kontrol positif (glibenklamid 0,63 mg/KgBB), kelompok B sebagai kontrol negatif (akuades), kelompok C (ekstrak rambut jagung 0,63 g/KgBB), kelompok D (ekstrak rambut jagung 1,26 g/KgBB) dan kelompok E (ekstrak rambut jagung 2,52 g/KgBB). Data di analisis menggunakan program SPSS, beda nyata antar perlakuan diuji dengan one way ANOVA dan dilanjutkan dengan LSD untuk melihat perbedaan signifikan antar setiap kelompok perlakuan. Hasil penelitian menunjukkan bahwa ekstrak rambut jagung memiliki efek menurunkan kadar gula darah dan dosis yang paling efektif ialah 2,52 g/KgBB. Penelitian ini menunjukkan bahwa ekstrak rambut jagung (Zea mays L.) memiliki efek menurunkan kadar gula darah pada tikus putih jantan galur wistar (Rattus norvegicus L.) yang diinduksi aloksan.

 

Kata kunci : Zea mays L., hiperglikemia, aloksan, Rattus norvegicus L.

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Published

2015-08-06

How to Cite

Koloay, K. (2015). UJI EFEKTIVITAS EKSTRAK ETANOL RAMBUT JAGUNG (Zea mays L.) TERHADAP PENURUNAN KADAR GULA DARAH TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.) YANG DIINDUKSI ALOKSAN. PHARMACON, 4(3), 34–40. https://doi.org/10.35799/pha.4.2015.8835

Issue

Vol. 4 No. 3 (2015): Pharmacon

Section

Articles

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