UJI EFEKTIVITAS EKSTRAK FLAVONOID DAN STEROID DARI GEDI (ABELMOSCHUS MANIHOT) SEBAGAI ANTI OBESITAS DAN HIPOLIPIDEMIK PADA TIKUS PUTIH JANTAN GALUR WISTAR

Abstract

Abelmoschus manihot L. has been used traditionally as folks medicine plant and it contain
flavonoid and steroid that has health benefit. The objectives of this research were to
determine anti obesity and hypolipidemic activity of flavonoid and steroid extract from
Abelmoschus manihot L. on white male Wistar induced with high content of protein and lipid
food. Anti obesity test were evaluated by the decreasing of rats weight, whereas
hypolipidemic test were evaluated by the decreasing of total cholesterol levels
photometrically using Liebermann-Burchard method. The rats were divided into four groups,
namely the negative control (distilled water), extract treatment groups (flavonoids and
steroids), and a positive control group (simvastatin). The percentations of Weight reducing
and cholesterol level were analyzed by ANOVA, if there were significant in groups, it
continued with Duncan Multiple Range Test. The results showed that treatment group posses
anti obesity activity, whereas flavonoid extract decrease 7.85% body weight of rats and
steroids extract were 13.70% of body weight. Flavonoids showed hypolipidemic effects by
decrease rats cholesterol levels by 86.45% and steroid extract decrease cholesterol levels by
72.53%.
Keywords : Abelmoschus manihot L., flavonoid extract, steroid extract, anti obesity,
hypolipidemic