Uji Efek Antidepresan Ekstrak Metanol Jamur Tlethong (Psilocybe cubensis) Pada Tikus Putih Jantan (Rattus norvegicus): ditinjau dari Immobility Time Dengan Metode Forced Swim Test

Abstract

ABSTRACT
Tlethong mushroom (Psilocybe cubensis) contains psilocybin that potential as antidepressant.
The aim of this research was to examine the effect of Tlethong extract as antidepressant on
white male wistar (Rattus norvegicus). Antidepressant test were evaluate on white male
wistar which divided into 5 groups. The first group were administered with aquadest as
negative control, Second group were administered with amitriptilin as positive control, third
group were administered with Tlethong extract with dose 500 mg/KgBB, 625 mg/KgBB and
750 mg/KgBB then tail suspension test were conducted. Immobility time dengan metode
forced swim test. Obtained data were analyzed by one way ANOVA. The result shows that
Tlethong extract possess antidepressant activity evaluated by its immobility time using forced
swim test method.
Keywords: Antidepressant, immobility time, forced swim test, tail suspension test, Psilocybe
cubensis