PENGARUH SUHU TERHADAP STABILITAS SERTA PENETAPAN KADAR TABLET FUROSEMIDA MENGGUNAKAN SPEKTROFOTOMETER UV-VIS

Abstract

Stability is the ability of product to maintain its nature and characteristics similar to its
origin during storage and use period. Furosemide is one of drugs product that works as diuretic.
The aim of this research was to study the effect of temperature on furosemide stability. The
method using in this research is factorial Complete Random design. There are two factors in this
research,factor A is temperature (40oC, 50 oC, and 60 oC) and factor B are period (60, 120 and
180 minutes). There are three samples in this research. Analysis of furosemide content using
Spectrophotometer UV-Vis at λ = 271 nm. Obtained data were analyzed using spss ver. 20. The
differences between variable were statistical analyzed. The result shows that the decreasing of
furosemide in tablet starts at temperature 50°Cafter60minutes heating for sample A and C.
Sample B decrease at temperature 50°C after 120 minutes heating.
Keywords: stability, furosemide, spectrophotometry UV-Vis