Small Lymphocytic Lymphoma Presenting as Breast Mass: A Rare Case Report

Authors

  • Christian Manginstar Universitas Sam Ratulangi
  • Marselus A. Merung Universitas Sam Ratulangi
  • Denny Saleh Universitas Sam Ratulangi
  • Marcella Merung Universitas Sam Ratulangi

DOI:

https://doi.org/10.35790/ecl.v12i2.46852

Abstract

Abstract: Primary breast lymphoma is rare and it accounts for around 0.5% of malignant breast neoplasms. Small lymphocytic lymphoma (SLL) is a subtype of non-Hodgkin lymphoma originating from a B-cell lineage. This report presents a case of primary SLL of the breast with lung metastasis that had excellent clinical response. We reported a 67-year-old female complained a right breast mass that suddenly appeared after she got massage on her right left arm. The mass was swollen and painless with no systemic complications. The specimen was submitted to histopathology department and it revealed small diffuse lymphocytic lymphoma. Chest X-ray showed a lung metastasis. The patient was then treated with CHOP regimens (Cyclophosphamid, Doxorubicin, Vincristin, and Prednison) and the clinical result was excellent. The side effects of the medication were minimal. In conclusion, primary breast lymphocytic lymphoma is rare and this case highlights the differential diagnosis for a painless breast mass. The treatment must be individualized and multimodal, with chemotherapy being the most accepted treatment.

Keywords: breast lymphoma; breast mass; malignancy

Author Biographies

Christian Manginstar, Universitas Sam Ratulangi

Division of Surgical Oncology, Department of Surgery, Medical Faculty, Universitas Sam Ratulangi – Prof. Dr. R. D. Kandou Hospital, Manado, Indonesia

Marselus A. Merung, Universitas Sam Ratulangi

Division of Surgical Oncology, Department of Surgery, Medical Faculty, Universitas Sam Ratulangi – Prof. Dr. R. D. Kandou Hospital, Manado, Indonesia

Denny Saleh, Universitas Sam Ratulangi

Division of Surgical Oncology, Department of Surgery, Medical Faculty, Universitas Sam Ratulangi – Prof. Dr. R. D. Kandou Hospital, Manado, Indonesia

Marcella Merung, Universitas Sam Ratulangi

General Surgery Resident, Department of Surgery, Medical Faculty, Universitas Sam Ratulangi, Manado, Indonesia

References

La Pinta M, Stagnitto D, Lengua G, Aicardi P, Loreti A, Bellioni M, et al. Primary breast lymphoma: case report and review of literature. Minerva Chir. 2007;62(1):33–7. Available from: https:// pubmed.ncbi.nlm.nih.gov/17287692/

Famà F, Barresi V, Giuffrè G, Todaro P, Mazzei S, Vindigni A, et al. An unusual presentation of secondary involvement of B-cell chronic lymphocytic leukemia. A case report. Tumori. 2008;94(4):617–20. Doi: 10.1177/030089160809400431

Moura C, Leite MI, Parreira R, Medeiros A. Primary breast lymphoma. J Surg Case Rep. 2020;(1):1-3. Doi: https://doi.org/10.1093/jscr/rjz405

Brogi E, Harris NL. Lymphomas of the breast: pathology and clinical behavior. Semin Oncol. 1999;26(3):357–64. Available from: https:// pubmed.ncbi.nlm.nih.gov/10375092/

Joks M, Myśliwiec K, Lewandowski K. Primary breast lymphoma - a review of the literature and report of three cases. Arch Med Sci. 2011;7(1):27–33. Doi: 10.5114/aoms.2011.20600

Khan N, Shaaban H, Guron G. Small lymphocytic lymphoma presenting as a breast lump: a rare presentation of non-Hodgkin’s lymphoma. Cureus. 2021;13(11):1-6. Doi: 10.7759/cureus.19401

Lyou CY, Yang SK, Choe DH, Lee BH, Kim KH. Mammographic and sonographic findings of primary breast lymphoma. Clin Imaging. 2007;31(4):234–8. Doi: 10.1016/j.clinimag.2007.02.028

Jennings WC, Baker RS, Murray SS, Howard CA, Parker DE, Peabody LF, et al. Primary breast lymphoma: the role of mastectomy and the importance of lymph node status. Ann Surg. 2007;245(5):784–9. Doi: 10.1097/01.sla.0000254418.90192.59

Mohamed KEH, Ali RAE. Primary breast lymphoma: a case report and review of the literature. Clin Pract. 2017;7(3):939. Doi: 10.4081/cp.2017.939

Wierda WG, Byrd JC, Abramson JS, Bilgrami SF, Bociek G, Brander D, et al. Chronic lymphocytic leukemia/small lymphocytic lymphoma, Version 4.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2020;18(2):185–217. Doi: 10.6004/jnccn.2020.0006

Downloads

Published

2024-02-19

How to Cite

Manginstar, C., Merung, M. A., Saleh, D., & Merung, M. (2024). Small Lymphocytic Lymphoma Presenting as Breast Mass: A Rare Case Report. E-CliniC, 12(2), 201–204. https://doi.org/10.35790/ecl.v12i2.46852

Issue

Section

Articles