Identifikasi Drug Related Problems (DRPs) pada Pasien Penyakit Jantung Koroner di Instalasi Rawat Inap CVBC RSUP Prof. Dr. R. D. Kandou Manado
DOI:
https://doi.org/10.35790/ecl.v13i2.60743Abstract
Abstract: Patients with coronary heart disease (CHD) are prone to Drug Related Problems (DRPs) due to the many therapies received by patients. This study aimed to identify the prevalence of DRPs in each category of CHD patients. This was a descriptive and retrospective study using medical records of CHD patients during the period September-November 2023 who fulfilled the inclusion criteria. The results obtained 64 CHD patients as samples. There were 27 patients (42.19%) who had the potential to experience DRPs with 31 cases of DRPs in the identified DRPs categories including indications without therapy (77.41%) and therapy without indications (22.59%). There were no DRPs in the categories of ineffective drugs, dose too high, and dose too low. In conclusion, the therapy obtained by coronary heart disease patients in the CVBC inpatient installation of Prof. Dr. R. D. Kandou Hospital Manado still experienced DRPs, especially in the categories of indication without therapy and therapy without indication.
Keywords: coronary heart disease; drug related problems
Abstrak: Pasien dengan penyakit jantung koroner (PJK) rentan mengalami Drug Related Problems (DRPs) karena terapi yang diterima pasien cukup banyak. Penelitian ini bertujuan untuk mengidentifikasi prevalensi kejadian DRPs pada setiap kategori dari pasien PJK. Jenis penelitian ialah deskriptif retrospektif dengan pengambilan data rekam medik pasien PJK yang memenuhi kriteria inklusi selama periode September-November 2023. Hasil penelitian mendapatkan 64 pasien PJK sebagai sampel. Terdapat 27 pasien (42,19%) yang berpotensi mengalami DRPs dengan 31 kejadian DRPs pada kategori DRPs indikasi tanpa terapi (77,41%) dan terapi tanpa indikasi (22,59%); tidak terdapat kejadian DRPs pada kategori obat tidak efektif, dosis terlalu tinggi, dan dosis terlalu rendah. Simpulan penelitian ini ialah terapi yang diperoleh pasien penyakit jantung koroner di instalasi rawat inap CVBC RSUP Prof. Dr. R. D. Kandou Manado masih mengalami kejadian Drug Related Problems, terutama pada kategori indikasi tanpa terapi dan terapi tanpa indikasi.
Kata kunci: penyakit jantung koroner; drug related problems
References
Riset Kesehatan Dasar (Riskesdas). Badan Penelitian dan Pengembangan. Jakarta: Kementerian Kesehatan RI; 2018
Lestari RD, Dewi R, Sanuddin M. Evaluasi penggunaan obat pada pasien penyakit jantung koroner di instalasi rawat inap RSUD Raden Mattaher Jambi. J Healthcare Technol Med. 2020;6(1):54-61. Available from: https://jurnal.uui.ac.id/index.php/JHTM/article/view/665
Martha AF. Evaluasi drug related problems (DRPs) pada pasien dengan diagnosa jantung koroner di salah satu rumah sakit Jakarta Utara [Skripsi]. Jakarta: UIN Syarif Hidayatullah; 2016. Available from: https://repository.uinjkt.ac.id/dspace/handle/123456789/34275
Lenander C, Elfsson B, Danielsson B, Midlöv P, Hasselström J. Effects of a pharmacist-led structured medication review in primary care on drug-related problems and hospital admission rates: a randomized controlled trial. Scand J Prim Health Care. 2014;32(4):180–6. Available from: http://dx.doi.org/10.3109/ 02813432.2014.972062
Jamal I, Amin F, Jamal A, Saeed A. Pharmacists interventions in reducing the incidences of drug related problems in any practice setting. Int Curr Pharm J. 2015;4(2):347–52. Available from: http://dx.doi.org/ 10.3329/icpj.v4i2.21483
Al-Arifi M, Abu-Hashem H, Al-Meziny M, Said R, Aljadhey H. Emergency department visits and admissions due to drug related problems at Riyadh military hospital (RMH), Saudi Arabia. Saudi Pharm J. 2014;22(1):17–25. Available from: http://dx.doi.org/10.1016/j.jsps.2013.01.001
Kawengian S, Wiyono WI, Mamarimbing M. Identifikasi drug related problems (DRPs) pada tahap administration pasien penyakit jantung koroner di Instalasi Rawat Inap RSUP Prof. Dr. R. D. Kandou Manado. Pharmacon. 2019;8(1):1. Available from: http://dx.doi.org/10.35799/pha.8.2019.29227
Sugiyono. Metode Penelitian Kuantitatif, Kualitatif, dan R&D. Bandung: Alfabeta; 2018.
Dahlan M, Sopitudin. Besar Sampel dan Cara Pengambilan Sampel dalam Penelitian Kedokteran dan Kesehatan (3rd ed). Jakarta: Salemba Medika; 2013.
Harvey RE, Coffman KE, Miller VM. Women-specific factors to consider in risk, diagnosis and treatment of cardiovascular disease. Women’s Health. 2015;11(2):239–57. Available from: http://dx.doi.org/ 10.2217/whe.14.64
Ryczkowska K, Adach W, Janikowski K, Banach M, Bielecka-Dabrowa A. Menopause and women’s cardiovascular health: is it really an obvious relationship? Arch Med Sci. 2022;19(2):458–66. Available from: http://dx.doi.org/10.5114/aoms/157308
Stanhewicz AE, Wenner MM, Stachenfeld NS. Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan. Am J Physiol-Heart Circ Physiol. 2018;315(6):H1569–88. Available from: http://dx.doi.org/10.1152/ajpheart.00396.2018
Deng B, Guo M. Risk factors and intervention status of cardiovascular disease in elderly patients with coronary heart disease. Health. 2020;12(07):857–65. Available from: http://dx.doi.org/10.4236/health.2020.127063
Lawton JS, Tamis-Holland JE, Bangalore S, Bates ER, Beckie TM, Bischoff JM, et al. 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145(11). Available from: http://dx.doi.org/10.1161/cir.0000000000001061
Lin CF, Chang YH, Chien SC, Lin YH, Yeh HY. Epidemiology of dyslipidemia in the Asia Pacific region. Int J Gerontol. 2018;12(1):2–6. Available from: http://dx.doi.org/10.1016/j.ijge.2018.02.010
Perkumpulan Endokrinologi Indonesia (PERKENI). 2021. Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia. PB PERKINI. Available from: https://pbperkeni.or.id/wp-content/uploads/2021/11/22-10-21-Website-Pedoman-Pengelolaan-dan-Pencegahan-DMT2-Ebook.pdf
Zuo T, Liu X, Jiang L, Mao S, Yin X, Guo L. Hyperuricemia and coronary heart disease mortality: a meta-analysis of prospective cohort studies. BMC Cardiovascular Disorders [Internet]. 2016;16(1). Available from: http://dx.doi.org/10.1186/s12872-016-0379-z
Ayele Y, Tesfaye ZT. Drug-related problems in Ethiopian public healthcare settings: Systematic review and meta-analysis. SAGE Open Medicine. 2021;9:205031212110097. Available from: http://dx.doi.org/ 10.1177/20503121211009728
Rashed AN, Neubert A, Tomlin S, Jackman J, Alhamdan H, AlShaikh A, et al. Epidemiology and potential associated risk factors of drug-related problems in hospitalised children in the United Kingdom and Saudi Arabia. Eur J Clin Pharmacol. 2012;68(12):1657–66. Available from: http://dx.doi.org/10.1007/ s00228-012-1302-x
Cipolle RJ, Strand LM, Morley PC. Pharmaceutical Care Practice: The Patient-Centered Approach to Medication Management Services (3rd ed). New Yoork: The McGraw-Hill; 2012.
Garin N, Sole N, Lucas B, Matas L, Moras D, Rodrigo-Troyano A, et al. Drug related problems in clinical practice: a cross-sectional study on their prevalence, risk factors and associated pharmaceutical interventions. Sci Rep. 2021;11(1). Available from: http://dx.doi.org/10.1038/s41598-020-80560-2
Prestinaci F, Pezzotti P, Pantosti A. Antimicrobial resistance: a global multifaceted phenomenon. Pathogens and Global Health [Internet]. 2015;109(7):309–18. Available from: http://dx.doi.org/10.1179/ 2047773215y.0000000030
Morusupalli RV, Khan AA, Mathai D, Ramanalah CJ, Leon TC, Khaleel M, et al. Prevalence and risk factors for hospital-acquired infections “clean care is safer care”. IJRSR. 2020;11(4):38021-8. Available from: https://api.semanticscholar.org/CorpusID:218862197
Perhimpunan Dokter Spesialis Kardiovaskular Indonessia (PERKI). Panduan Praktik Klinis dan Clinical Pathway. Jakarta: Centra Communications. 2016. Available from: https://www.inaheart.org/storage/ guideline/d0fc9c0365362ca4586f8376e378b023.pdf
Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Kardiologia Polska. 2018;76(2):229–313. Available from: http://dx.doi.org/10.5603/kp.2018.0041
Perhimpunan Reumatologi Indonesia. Pedoman Diagnosis dan Pengelolaan Gout. Jakarta: Perhimpunan Reumatologi Indonesia; 2018 Available from: https://reumatologi.or.id/wp-content/uploads/2020/10/ Rekomendasi_GOUT_final.pdf
Lepor NE. Acute Coronary Syndromes: NICE guideline. Reviews in Cardiovascular Medicine. 2020. National Institute for Health and Care Excellence. Available from: https://www.nice.org.uk/guidance/ng185
Valgimigli M, Bueno H, Byrne RA, Collet JP, Costa F, Jeppsson A, et al. Special article 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS. Revista Española de Cardiología (English Edition). 2018;71(1):42. Available from: http://dx.doi.org/ 10.1016/j.rec.2017.11.020
Truong TTA, Phan NK, Vo QV, Diep HG, Vuong HTK, Le TV, et al. Masalah terkait obat dalam peresepan penyakit arteri koroner di Vietnam: studi cross-sectional. Pengobatan Tropis & Kesehatan Internasional. 2019;24(11):1335–40. Available from: http://dx.doi.org/10.1111/tmi.13310
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Carmelita Laloan, Weny I. Wiyono, Deby A. Mpila

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
COPYRIGHT
Authors who publish with this journal agree to the following terms:
Authors hold their copyright and grant this journal the privilege of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that permits others to impart the work with an acknowledgment of the work's origin and initial publication by this journal.
Authors can enter into separate or additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (for example, post it to an institutional repository or publish it in a book), with an acknowledgment of its underlying publication in this journal.
Authors are permitted and encouraged to post their work online (for example, in institutional repositories or on their website) as it can lead to productive exchanges, as well as earlier and greater citation of the published work (See The Effect of Open Access).