Hubungan Kadar High Density Lipoprotein (HDL) dengan Tekanan Darah pada Pasien Hipertensi
DOI:
https://doi.org/10.35790/ecl.v13i2.60874Abstract
Abstract: One of the indicators to identify a person's risk of hypertension is by measuring lipid profile. Measuring the high-density lipoprotein (HDL) cholesterol level in the lipid profile plays an important role in evaluating the risk of hypertension. This study aimed to determine the relationship between HDL level and blood pressure among patients with hypertension at ODSK Hospital in North Sulawesi Province. This was a retrospective and analytical study using a cross-sectional design. The data used in this study were medical records of all patients with hypertension at the ODSK Hospital in the North Sulawesi Province during the period of April 2022 to September 2023. Samples consisted of patients with hypertension at the ODSK Hospital who meet the inclusion and exclusion criteria. The results showed that the majority patients with hypertension patients with low HDL levels were female (64.9%). Additionally, based on blood pressure the highest percentage of patients with hypertension was in the grade 1 category (57.1%). However, there was no significant correlation between HDL level and blood pressure (both systolic and diastolic) with p-values>0.05 (p=0.683 and p=0.121). In conclusion, there is no significant relationship between HDL level and blood pressure in patients with hypertension at ODSK Regional Hospital, North Sulawesi Province.
Keywords: hypertension; blood pressure; high density lipoprotein
Abstrak: Salah satu indikator yang digunakan untuk mengidentifikasi potensi seseorang terkena penyakit hipertensi ialah dengan mengukur profil lipid. Pengukuran kadar kolesterol high-density lipoprotein (HDL) dalam profil lipid berperan penting dalam mengevaluasi risiko hipertensi. Penelitian ini bertujuan untuk mengevaluasi hubungan kadar HDL dengan tekanan darah pada pasien hipertensi di RSUD ODSK Provinsi Sulawesi Utara. Jenis penelitian ialah analitik retrospektif dengan desain potong lintang. Data yang digunakan ialah rekam medik seluruh pasien hipertensi di RSUD ODSK Provinsi Sulawesi Utara pada periode April 2022 – September 2023. Sampel meliputi kelompok kasus pasien hipertensi di RSUD ODSK Provinsi Sulawesi Utara yang memenuhi kriteria inklusi dan eksklusi. Hasil penelitian mendapatkan bahwa berdasarkan kadar HDL, yang terbanyak yaitu kategori kadar HDL pada perempuan <50 mg/dL (64,9%), dan berdasarkan tekanan darah yang terbanyak yaitu kategori derajat 1 (57,1%). Tidak terdapat hubungan bermakna antara kadar HDL dengan tekanan darah sistol dan diastol) pada pasien hipertensi dengan nilai p>0,05 (p=0,683 dan p=0,121). Simpulan penelitian ini ialah tidak terdapat hubungan bermakna antara kadar HDL dengan tekanan darah pada pasien Hipertensi di RSUD ODSK Provinsi Sulawesi Utara.
Kata kunci: hipertensi; tekanan darah; high density lipoprotein
References
Naamin J, Kuhon F V, Ottay RI. Gambaran penanganan penyakit kronis: program rujuk balik penyakit jantung koroner pada dokter keluarga di Kota Manado. Manado; 2022 [cited 2023 Aug 16]. Available from: https://ejournal.unsrat.ac.id/v3/index.php/JKKT/article/view/44875
Linda O, Sri Rahayu L. Prevensi awal dan lanjutan penyakit degeneratif untuk usia dewasa di masa pandemi Covid-19. 2021 [cited 2023 Aug 16]. Available from: https://doi.org/10.22236/ardimas.v2i1.7572
Murphy M, Srivastava R, Deans K. Clinical Biochemistry: An Illustrated Colour Text. Hypertension (6th ed). Elsevier; 2019. p. 138–9.
WHO. Hypertension overview. 2022 [cited 2023 Aug 16]. Available from: https://www.who.int/health-topics/hypertension
WHO. Hypertension. 2021 [cited 2023 Aug 16]. Available from: https://www.who.int/news-room/fact-sheets/detail/hypertension
Kementerian Kesehatan Republik Indonesia. Hasil Utama Riskesdas 2018 [Internet]. Jakarta: Badan Litbangkes, Depkes RI. Jakarta; 2018 [cited 2023 Aug 16]. 158 p. Available from: https://kesmas.kemkes.go.id/assets/ upload/dir_519d41d8cd98f00/files/Hasil-riskesdas-2018_1274.pdf
Badan Pusat Statistik Kota Manado. Jumlah Kasus 10 Jenis Penyakit Terbanyak di Kota Manado 2020. 2020 [cited 2023 Aug 16]. Available from: https://manadokota.bps.go.id/
Nurtya A, Tjempakasari A, Maimunah U, Sulistiawati, Harsa IMS. Hypertension and lipid profiles in middle-aged male patients: a study at a tertiary hospital in Surabaya, Indonesia. Folia Medica Indonesiana. 2023;59(4):321-7. Available from: https://doi.org/10.20473/fmi.v59i4.49674
Pujiastuti SER. The effect of nanoparticles turmeric consumption (Curcuma Domestica Val) on blood pressure and lipid profile in hypertension patients with hypercholesterolemia. International Journal of Nursing and Health Services (IJNHS). 2021;4(5):3. Available from: https://doi.org/10.35654/ijnhs.v4i5.487
Goldman L, Cooney KA. Goldman Cecil Medicine. Disorders of Lipid Metabolism (27th ed). Kennedy J., editor. Vol. 978-0-323-93035–2. Elsevier; 2023. p. 1404–15.
Murphy M, Srivastava R, Deans K. Lipoprotein metabolism. Clinical Biochemistry: An Illustrated Colour Text (6th ed). Elsevier; 2019. p. 134–5..
Rakel D, Minichiello VJ, Devries S . Integrative Medicine. Coronary Artery Disease (5th ed). Elsevier; 2023. p. 233–41.
Rafieian-Kopaei M, Setorki M, Doudi M, Baradaran A, Nasri H. Atherosclerosis: process, indicators, risk factors and new hopes. Int J Prev Med. 2014;5(8):927–46. Available from: https:// pubmed.ncbi. nlm.nih.gov/25489440/
Rafsanjani MS, Asriati A, Kholidha AN, Akifariki La Ode. Hubungan kadar high density lipoprotein (HDL) dengan kejadian hipertensi. Jurnal Profesi Medika. 2019;13(2):74-81. Available from: https://doi.org/ 10.33533/jpm.v13i2.1274
Cho KH, Park HJ, Kim JR. Decrease in serum HDL-C level is associated with elevation of blood pressure: correlation analysis from the Korean National Health and Nutrition Examination Survey 2017. Int J Environ Res Public Health. 2020;17(3):1101. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036966/
Pebrisiana P, Tambunan L, Baringbing E. The relationship of characteristics with the event of hypertension in outpatient patients in RSUD Dr. Doris Sylvanus Central Kalimantan Province. Jurnal Surya Medika. 2022;8(3):176-86. Available from: https://doi.org/10.33084/jsm.v8i3.4511
Suryonegoro SB, Elfa MM, Noor MS. Literature Review: Hubungan hipertensi pada wanita menopause dan usia lanjut terhadap kualitas hidup. Homeostasis. 2021;4(2):387-97. Available from: https://doi.org/ 10.20527/ht.v4i2.4030
Khasanah DN. The risk factors of hypertension in Indonesia (Data study of Indonesian family life survey 5). Journal of Public Health Research and Community Health Development. 2022;5(2):80-89. Available from: s://doi.org/10.20473/jphrecode.v5i2.27923
Bura ASN, Mahmud NU, Masriadi. Gambaran karakteristik perilaku hipertensi lansia di wilayah kerja Puskesmas Antara Makassar. Window of Public Health Journal. 2023;4(4):678-89. Available from: https://doi.org/10.33096/woph.v4i4.811
Pramitasari A, Cahyati WH. Kejadian hipertensi pada lansia di wilayah kerja Puskesmas Banyudono 1 Kabupaten Boyolali. Higeia. 2022;6(4):204-15. Available from: https://doi.org/10.15294/higeia.v6i4.57037
Akbar F, Nur H, Humaerah UI. Karakteristik hipertensi pada lanjut usia di Desa Buku (Characteristics of hypertension in the elderly). Jurnal Wawasan Kesehatan. 2020;5(2):35-41. Available from: https://stikessantupaulus.e-journal.id/JWK/article/view/88
Jabani AS, Kusnan A, Cristian IMB. Prevalensi dan faktor risiko hipertensi derajat 2 di wilayah kerja Puskesmas Poasia Kota Kendari. Nursing Update. 2021;12(4):31-42. Available from: https://doi.org/ 10.36089/nu.v12i4.494
Santosa LHK, Chasani S, Pramudo SG. Faktor risiko kejadian hipertensi di Puskesmas Kenduran, Kabupaten Tuban. Jurnal Kedokteran Diponerogo. 2016;5(4):1182-91. Available from: https://doi.org/10.14710/ dmj.v5i4.14806
Wang HH, Wong MC, Mok RY, Kwan MW, Chan WM, Fan CK, et al. Factors associated with grade 1 hypertension: implications for hypertension care based on the Dietary Approaches to Stop Hypertension (DASH) in primary care settings. BMC Fam Pract. 2015;16:26. Doi: 10.1186/s12875-015-0239-4
Purwa SAA, Suryandari D. Description of high density lipoprotein (HDL) and low density lipoprotein (LDL) levels in hypertension patients in Dr. Soeratno Gemolong [Undergraduate degree]. Surakarta: Universitas Kusuma Husada; 2022.
Utama FW, Herawati S, Wande IN. Gambaran rasio profil lipid pada pasien penyakit jantung koroner di RSUP Sanglah periode Januari-Juni 2018. E-Jurnal Medika Udayana. 2021;10(4):23-8. Available from: https://ojs.unud.ac.id/index.php/eum
Thristy I, Mardia RS, Mampatdi CM, Karim Chan MZ. Gambaran tingkat stres dan kadar HDL kolesterol darah pada mahasiswa fakultas kedokteran. Pandu Husada. 2020;1(3):149-53. Doi: https://doi.org/10.30596/jph.v1i3.4907
Ridayani N, Santri NF, Naim R. Gambaran hasil pemeriksaan kadar high density lipoprotein (HDL) dan low density lipoprotein (LDL) pada penderita obesitas di Rumah Sakit Umum Daerah Syekh Yusuf Kabupaten Gowa. Jounal Media Laboran. 2018;8(1):15–20.
Andini J, Nugroho P, Dewi EB. Hubungan kadar high density lipoprotein HDL terhadap kendali tekanan darah pada pasien hipertensi poliklinik penyakit dalam RSIPN Dr. Cipto Mangunkusumo Jakarta [Skripsi]. Jakarta: Universitas Indonesia; 2013.
Mandala AS, Esfandiari F, Anton KN. Hubungan tekanan darah terkontrol dan tidak terkontrol terhadap kadar high density lipoprotein pasien hipertensi. Jurnal Ilmiah Kesehatan Sandi Husada. 2020; 11(1):379-386. Doi: 10.35816/jiskh.v11i1.296
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