Evaluasi Penggunaan Obat Proton Pump Inhibitors pada Pasien Rawat jalan dengan Gastroesophageal Reflux Disease di Rumah Sakit Swasta
DOI:
https://doi.org/10.35790/ecl.v13i3.61406Abstract
Abstract: Proton pump inhibitors (PPIs) are one of the primary therapies for managing gastroesophageal reflux disease (GERD). Inadequate dosing for managing GERD symptoms can result in prolonged discomfort and reduced quality of life. The GERD Questionnaire (GERDQ) is a questionnaire-based tool designed to aid in the diagnosis of GERD and assess therapeutic response. This study aimed to evaluate the use of PPIs based on demographic factors, dosing accuracy, and appropriate use as assessed by the GERDQ. This was a descriptive and observational study with a retrospective approach, using medical records of GERD patients in the Outpatient Department of a Type C Private Hospital for the period of January 2024 to September 2024. The results showed that most patients were aged 36-40 years (30%), married (>50%), occupation as students (33.,3%), and females (73.,3%). Accurate drug dosing was observed in 76.7% of cases. However, the evaluation of GERDQ progression could not be fully conducted due to limitations in medical record data. In conclusion, the majority of GERD patients are female, young adults, married, and employed as students or college students. Most patients received medication doses according to the guidelines. However, the appropriateness of drug use could not be assessed through improvements in GERDQ
Keywords: proton pump inhibitors; gastroesophageal reflux disease; dosage accuracy
Abstrak: Proton pump inhibitor (PPI) merupakan salah satu terapi utama untuk menangani gastroesophageal reflux diseases (GERD). Dosis yang tidak memadai untuk mengatasi gejala GERD dapat menyebabkan ketidaknyamanan berkepanjangan dan penurunan kualitas hidup. GERD questionnaire (GERDQ) dikembangkan untuk membantu diagnosis GERD dan mengukur respons terhadap terapi. Penelitian ini bertujuan untuk mengevaluasi penggunaan obat PPI berdasarkan demografi, ketepatan dosis, dan penggunaan tepat yang dinilai oleh GERDQ. Jenis penelitian ialah observasional deskriptif dengan pendekatan retrospektif berdasarkan rekam medis pasien GERD rawat jalan salah satu RS Swasta tipe C di Minahasa periode Januari hingga September 2024. Hjasil penelitian mendapatkan berdasarkan usia didapatkan yang terbanyak ialah pasien berusia 36-40 tahun (30%), sudah kawin (>50%), pekerjaan pelajar atau mahasiswa (33,3%), dan jenis kelamin perempuan (73,3%). Tepat dosis obat sebanyak 76,7%. Evaluasi perkembangan GERDQ tidak dapat dilakukan secara penuh karena keterbatasan data rekam medis. Simpulan penelitian ini ialah mayoritas pasien GERD ialah perempuan, usia dewasa muda, sudah kawin, dan memiliki pekerjaan sebagai pelajar atau mahasiswa. Mayoritas pasien sudah mendapatkan dosis obat sesuai dengan panduan. Ketepatan penggunaan obat tidak dapat dinilai dengan perbaikan GERDQ.
Kata kunci: proton pump inhibitor; gastroesophageal reflux disease; tepat dosis
References
Ariyani F, Martini M, Hestiningsih R, Fauzi M. Gambaran perilaku (pengetahuan, sikap, dan perilaku) pencegahan gastroesophageal reflux disease (GERD) pada mahasiswa. Jurnal Kesehatan Masyarakat. 2024;12(1):115–9. Available from: https://ejournal3.undip.ac.id/index.php/jkm/article/view/39705
Putri AKZ, Sopiah P, Ridwan H. Modifikasi gaya hidup dan kajian pengobatan pada penderita gastroesophageal reflux disease (GERD). Jurnal Ilmiah Keperawatan. 2023;9(2):358–66. Available from: https://journal. stikespemkabjombang.ac.id/index.php/jikep/article/view/1499
Zeind CS, Carvalho MG. Applied Therapeutics: The Clinical Use of Drugs (11the ed). Philadelphia: Wolters Kluwer Health; 2018. Available from: https://premiumpharmacy.lwwhealthlibrary.com/book.aspx?bookid=2324
Greenberger N, Blumberg R, Burakoff R. Current Diagnosis & Treatment Gastroenterology, Hepatology, & Endoscopy. (3rd ed). McGraw-Hill Education/Medical; 2015. Available from: https://accessmedicine. mhmedical.com/book.aspx?bookid=1621
Sadafi S, Azizi A, Pasdar Y, Shakiba E, Darbandi M. Risk factors for gastroesophageal reflux disease: a population-based study. BMC Gastroenterol. 2024;24(1):1–7. Available from: https://bmcgastroenterol. biomedcentral. com/articles/10.1186/s12876-024-03143-9
Syam AF, Sobur CS, Hapsari FCP, Abdullah M, Makmun D. Prevalence and risk factors of GERD in Indonesian population—an internet-based study. Adv Sci Lett. 2017;23(7):6734–8. Available from: https://scholar.ui.ac.id/en/publications/prevalence-and-risk-factors-of-gerd-in-indonesian-populationan-in
Gunawan DF, Waleleng BJ, Polii EBI. Profil pasien endoskopi gastrointestinal di RSUP Prof. Dr. R. D. Kandou periode Januari 2018-Agustus 2019. e-CliniC. 2019;7(2):157–63. Available from: https://ejournal.unsrat.ac.id/ index.php/eclinic/article/view/26834
DiPiro JT, Yee GC, Haines ST, Nolin TD, Ellingrod VL, Posey LM. No Title. In: DiPiro’s Pharmacotherapy: A Pathophysiologic Approach (12th ed). New York, NY: McGraw Hill; 2023. Available from: http://accesspharmacy.mhmedical.com/content.aspx?aid=1201057727
Ndraha S, Harefa GA, Khumar B. Hubungan gaya hidup terhadap kejadian GERD (Gastroesophageal Reflux Disease) di RSUD Koja Jakarta Utara. Jurnal MedScientiae. 2023;2(3):341–6. Available from: https://ejournal.ukrida.ac.id/index.php/ms/article/view/2909
Lin CC, Geng JH, Wu PY, Huang JC, Hu HM, Chen SC, et al. Sex difference in the associations among risk factors with gastroesophageal reflux disease in a large Taiwanese population study. BMC Gastroenterol. 2024;24(1):165. Available from: https://doi.org/10.1186/s12876-024-03254-3
Tseng H, Lee JI, Geng JH, Chen SC. Sex difference in the associations among risk factors with depression in a large Taiwanese population study. Front Public Health. 2023;11. Available from: https://www.frontiersin. org/articles/10.3389/fpubh.2023.1070827/full
Tayibu AM, Rijal S, Musa IM, Hapsari P, Natsir P. Karakteristik penderita gastroesophageal reflux disease. Fakumi Medical Journal. 2024;4(5):402–11. Available from: https://fmj.fk.umi.ac.id/index.php/fmj/article/view/451
Clarrett DM, Hachem C. Gastroesophageal reflux disease (GERD). Mo Med. 2019;115(3):214–8. Available from: https://www.ncbi.nlm.nih.gov/pubmed/30228725
Andrade ML, Herbella FAM. The sequel of age and frailty on the pathophysiology and treatment of surgical esophageal diseases. Annals of Esophagus. 2024;7(2):5–5. Available from: https://aoe.amegroups.com/article/view/7403/html
Yamasaki T, Hemond C, Eisa M, Ganocy S, Fass R. The changing epidemiology of gastroesophageal reflux disease: are patients getting younger? J Neurogastroenterol Motil. 2018;24(4):559–69. Available from: http://www.jnmjournal.org/journal/view.html?doi=10.5056/jnm18140
Suputra IGLRD, Saputra IWE. Hubungan gastroesophageal reflux disease dengan kualitas tidur pada pasien rawat jalan di RSUD Sanjiwani Gianyar. Jurnal Ilmu Kedokteran dan Kesehatan [Internet]. 2023;10(2):1546–53. Available from: https://ejurnalmalahayati.ac.id/index.php/kesehatan/article/view/9378
Nirwan JS, Hasan SS, Babar ZUD, Conway BR, Ghori MU. Global prevalence and risk factors of gastro-oesophageal reflux disease (GORD): systematic review with meta-analysis. Sci Rep. 2020;10(1):5814. Available from: https://pubmed.ncbi.nlm.nih.gov/32242117/
Kariri AM, Darraj MA, Wassly A, Arishi HA, Lughbi M, Kariri A, et al. Prevalence and risk factors of gastroesophageal reflux disease in Southwestern Saudi Arabia. Cureus. 2020;12(1):1–9. Available from: https://www.cureus.com/articles/25967-prevalence-and-risk-factors-of-gastroesophageal-reflux-disease-in-southwestern-saudi-arabia
Kazakova T, Danoff R, Esteva I, Shchurin A. Gastro-esophageal reflux disease in primary care practice: a narrative review. AOE. 2023;6:25–25. Available from: https://aoe.amegroups.com/article/view/7211/html
Delshad SD, Almario CV, Chey WD, Spiegel BMR. Prevalence of gastroesophageal reflux disease and proton pump inhibitor-refractory symptoms. Gastroenterology. 2020;158(5):1250-61.e2. Available from: https://doi.org/ 10.1053/j.gastro.2019.12.014
Baklola M, Terra M, Badr A, Fahmy FM, Elshabrawy E, Hawas Y, et al. Prevalence of gastro-oesophageal reflux disease, and its associated risk factors among medical students: a nation-based cross-sectional study. BMC Gastroenterol. 2023;23(1):269. Available from: https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-023-02899-w
Bin Abdulrahman KA, Alsaif AF, Almehaidib IA, Almtehe MA, Alqahtani NM, Alabdali AK. Prevalence and risk factors of gastro-esophageal reflux disease among college students at a public university in Riyadh, Saudi Arabia. J Family Med Prim Care. 2024;13(4):1401–7. Available from: https://journals.lww.com/ 10.4103/jfmpc.jfmpc_1715_23
Kementerian Kesehatan. Keputusan Menteri Kesehatan Republik Indonesia tahun 2022 Tentang Panduan Praktik Klinis di FKTP. Kementerian Kesehatan. 2022. p. 122–5. Available from: https://paralegal.id/peraturan/ keputusan-menteri-kesehatan-nomor-hk-01-07-menkes-1186-2022/
Shanika LGT, Reynolds A, Pattison S, Braund R. Proton pump inhibitor use: systematic review of global trends and practices. Eur J Clin Pharmacol. 2023;79(9):1159–72. Available from: https://doi.org/10.1007/s00228-023-03534-z
Wabe N, Urwin R, Meulenbroeks I, Seaman K, Raban MZ, Neupane S, et al. Over- and underuse of proton pump inhibitors in nursing homes : a multisite longitudinal cohort study. J Am Med Dir Assoc. 2024;(December):105393. Available from: https://doi.org/10.1016/j.jamda.2024.105393
Mambo CD, Masengi ASR, Onibala FWR. Pengaruh penggunaan proton pump inhibitors (PPIs) jangka panjang terhadap kanker lambung. e-CliniC. 2023;12(1):6–15. Available from: https://ejournal.unsrat.ac.id/ v3/index.php/eclinic/article/view/45428
Helgadottir H, Bjornsson ES. Problems associated with deprescribing of proton pump inhibitors. Int J Mol Sci [Internet]. 2019;20(21):5469. Available from: https://www.mdpi.com/1422-0067/20/21/5469
Tielemans MM, van Oijen MGH. Online follow-up of individuals with gastroesophageal reflux disease using a patient-reported outcomes instrument: results of an observational study. BMC Gastroenterol [Internet]. 2013;13(1):144. Available from: https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-13-144
Tandarto K, Tenggara R, Chriestya F, Steffanus M. Correlation between quality of life and gastroesophageal reflux disease. Majalah Kedokteran Bandung. 2020;52(2):81–6. Available from: http://journal.fk.unpad.ac.id/index. php/mkb/article/view/2003
Fahrial A, Chaidir S, Kaka A, Marcellus R, Murdani S, Tjahjadi A, et al. Revisi Konsensus Nasional Penatalaksanaan Penyakit Refluks Gastroesofageal [Internet]. Cikini, Jakarta Pusat: Perkumpulan Gastroenterologi Indonesia; 2019. 1–20 p. Available from: https://pbpgigastro.com/pedoman/konsensus/
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