Asosiasi Kadar Hemoglobin dan Indeks Massa Tubuh terhadap Kualitas Hidup Pasien Penyakit Ginjal Kronik Stadium 5 Hemodialisis
DOI:
https://doi.org/10.35790/msj.v4i1.44683Abstract
Abstract: The prevalence of chronic kidney disease (CKD) increases every year, and majority of patients suffer from its complications namely anemia. Chronic inflammation also affects nutritional status, therefore, the patients tend to have a low body mass index (BMI). Low hemoglobin and BMI will cause a decrease in quality of life. This study aimed to determine the association of hemoglobin and BMI to the quality of life of patients with CKD stage 5 hemodialysis (CKD 5 HD). This was a cross-sectional study with 42 subjects with CKD 5 HD more than three months. Retrieval of hemoglobin data obtained through medical records, assessment of nutritional status by BMI calculations, and assessment of quality of life by interviewing the Short Form 36 questionnaire (SF-36). The results found that the analysis of the association between hemoglobin and the SF-36 score, carried out with the Pearson test, obtained a r-value of 0.330 and a p-value of 0.033. Analysis of the association between BMI and the SF-36 score carried out using the Kruskal-Wallis test, obtained a p-value of 0.890. In conclusion, there is an association between hemoglobin and quality of life, albeit, there is no association between BMI and quality of life in CKD 5 HD patients.
Keywords: hemoglobin; body mass index; short form 36; chronic kidney disease; hemodialysis
Abstrak: Prevalensi penyakit ginjal kronik (PGK) meningkat setiap tahunnya dan mayoritas pasien mengalami komplikasi PGK yaitu anemia. Inflamasi kronik juga berpengaruh terhadap status nutrisi sehingga pasien tersebut cenderung memiliki indeks massa tubuh (IMT) rendah. Rendahnya hemo-globin dan IMT akan menyebabkan penurunan kualitas hidup. Penelitian ini bertujuan untuk menge-tahui asosiasi hemoglobin dan IMT terhadap kualitas hidup pasien penyakit ginjal kronik stadium 5 hemodialisis (PGK 5 HD). Penelitian ini merupakan studi potong lintang dengan subjek sebanyak 42 pasien PGK 5 HD lebih dari tiga bulan. Pengambilan data hemoglobin diperoleh melalui rekam medik, penilaian status nutrisi dengan perhitungan IMT, dan penilaian kualitas hidup diperoleh dengan wawancara kuesioner Short Form 36 (SF-36). Analisis asosiasi antara hemoglobin dengan skor SF-36. Hasil analisis dengan uji Pearson mendapatkan nilai r=0,330 dan p=0,033. Analisis asosiasi antara IMT dengan skor SF-36, yang dilakukan dengan uji Kruskal-Wallis mendapatkan nilai p=0,890. Simpulan penelitian ialah terdapat asosiasi antara hemoglobin dengan kualitas hidup namun tidak terdapat asosiasi antara IMT dengan kualitas hidup pada pasien PGK 5 HD.
Kata kunci: hemoglobin; indeks massa tubuh; short form 36; penyakit ginjal kronik; hemodialisis
References
Perhimpunan Nefrologi Indonesia. Konsesus Manajemen Anemia Pada Penyakit Ginjal Kronik. Jakarta: PERNEFRI; 2011.
Gaitonde DY, Cook DL, Rivera IM. Chronic Kidney Disease: Detection and Evaluation. Chronic Kidney Dis. 2017;96(12):776-83.
Suwitra K. Buku Ajar Ilmu Penyakit Dalam (6th ed). Jakarta: InternaPublishing; 2014. p. 2156–65.
Kementerian Kesehatan RI. Laporan Nasional RISKESDAS 2018. Jakarta: Kementerian Kesehatan RI: Badan Penelitian dan Pengembangan Kesehatan; 2019.
Perhimpunan Nefrologi Indonesia. 11th Report of Indonesian Renal Registry. Jakarta: PERNEFRI; 2018. p. 46.
Kandarini Y. Penatalaksanaan Anemia Pada Penyakit Ginjal Kronik. Denpasar: Universitas Udayana; 2017.
Hanna RM, Streja E, Kalantar-Zadeh K. Burden of anemia in chronic kidney disease: beyond erythro-poietin. Adv Ther. 2021;38(1):52–75.
Batchelor EK, Kapitsinou P, Pergola PE, Kovesdy CP, Jalal DI. Iron deficiency in chronic kidney disease: updates on pathophysiology, diagnosis, and treatment. J Am Soc Nephrol. 2020;31(3):456–68.
Gafter-Gvili A, Schechter A, Rozen-Zvi B. Iron deficiency anemia in chronic kidney disease. Acta Haematol. 2019;142(1):44–50.
Nakanishi T, Kimura T, Kuragano T. The hepcidin-anemia axis: pathogenesis of anemia in chronic kidney disease. In: Nakanishi T, Kuragano T, editors. Contributions to Nephrology [Internet]. 2019 [cited 2022 Oct 29]. p. 124–34. Available from: https://www.karger.com/Article/FullText/496636
Harmer M, Wootton S, Gilbert R, Anderson C. Association of nutritional status and health-related quality of life in children with chronic kidney disease. Qual Life Res. 2019;28(6):1565–73.
Par’i H, Wiyono S, Harjatmo T. Penilaian Status Gizi. Vol. 1. Jakarta: Kementerian Kesehatan Republik Indonesia: Pusat Pendidikan Sumber Daya Manusia Kesehatan; 2017.
Hoshino J. Renal rehabilitation: exercise intervention and nutritional support in dialysis patients. Nutrients. 2021;13(5):1444.
Tannor EK, Archer E, Kapembwa K, van Schalkwyk SC, Davids MR. Quality of life in patients on chronic dialysis in South Africa: a comparative mixed methods study. BMC Nephrol. 2017; 18(1):4.
Manavalan M, Majumdar A, Harichandra Kumar K, Priyamvada P. Assessment of health-related quality of life and its determinants in patients with chronic kidney disease. Indian J Nephrol. 2017; 27(1):37.
Research and Development Corporation. Scoring Instructions for the 36-Item Short Form Survey (SF-36). RAND; 2009. Available from: 36-Item Short Form Survey Instrument (SF-36) | RAND
Charles C, Ferris AH. Chronic kidney disease. Prim Care Clin Off Pract. 2020;47(4):585–95.
Senduk CR, Palar S, Rotty LWA. Hubungan anemia dengan kualitas hidup pasien penyakit ginjal kronik yang sedang menjalani hemodialisis reguler. e-CliniC. 2016;4(1) [cited 2022 Oct 29]. Available from: https://ejournal.unsrat.ac.id/index.php/eclinic/article/view/10941
Kefale B, Alebachew M, Tadesse Y, Engidawork E. Quality of life and its predictors among patients with chronic kidney disease: A hospital-based cross sectional study. PLOS ONE. 2019;14(2):e0212184.
Tannor EK, Norman BR, Adusei KK, Sarfo FS, Davids MR, Bedu-Addo G. Quality of life among patients with moderate to advanced chronic kidney disease in Ghana - a single centre study. BMC Nephrol. 2019;20(1):122.
Kim YJ, Han KD, Cho KH, Kim YH, Park YG. Anemia and health-related quality of life in South Korea: data from the Korean national health and nutrition examination survey 2008–2016. BMC Public Health. 2019;19(1):735.
Asghar MS, Ahsan MN, Mal P, Tahir MJ, Yasmin F, Abbasher Hussien Mohamed Ahmed K. Assessment of quality of life determinants in hemodialysis patients of a developing country: A cross-sectional study during ongoing COVID-19 pandemic. Medicine (Baltimore). 2022;101(31):e29305.
Günalay S, Öztürk YK, Akar H, Mergen H. The relationship between malnutrition and quality of life in haemodialysis and peritoneal dialysis patients. Rev Assoc Médica Bras. 2018;64(9):845–52.
Pommer W. Preventive nephrology: the role of obesity in different stages of chronic kidney disease. Kidney Dis. 2018;4(4):199–204.
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