Profil Penyandang Diabetes Melitus Tipe 2 Disertai Anemia di Poli Endokrin RSUP Prof. Dr. R. D. Kandou Manado Periode September-November 2023
DOI:
https://doi.org/10.35790/msj.v7i1.58525Abstract
Abstract: Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by elevated blood sugar level. Anemia is a hematological disorder that often occurs in T2DM patients due to complication of secondary diseases, such as kidney dysfunction. The potential for anemia in T2DM patients can worsen the complications. This study aimed to determine the profile of T2DM patients with anemia at the endocrine polyclinic of Prof. Dr. R. D. Kandou Hospital from September to November 2023. This was a prospective and descriptive study with a cross-sectional design, using medical records at the endocrine polyclinic. The results showed that T2DM patients with anemia in this study (n=40) were dominated by females (55%) and age group of 45-60 years (62.5%). The average levels in laboratory examination were, as follows: HbA1c was 8.683, hemoglobin was 9.583, creatinine was 3.080, and eLFG was 23.38. Classification of anemia types based on erythrocyte morphology was dominated by hypochromic microcytic anemia, experienced by females (47.5%) and in the age group of 45-60 years (55%). In conclusion, the majority of type 2 diabetes mellitus patients with anemia are females aged 45-60 years who experience hypochromic microcytic anemia.
Keywords: type 2 diabetes mellitus; anemia; HbA1c glomerular filtration rate
Abstrak: Diabetes melitus tipe 2 (DMT2) adalah gangguan metabolisme yang ditandai adanya peningkatan gula darah. Anemia merupakan gangguan hematologi yang sering terjadi pada penyandang DMT2 yang disebabkan oleh komplikasi penyakit sekunder, seperti gangguan fungsi ginjal. Potensi anemia pada pasien DMT2 dapat memperburuk komplikasi. Penelitian ini bertujuan untuk mengetahui profil penyandang DMT2 disertai anemia di Poli Endokrin RSUP Prof. Dr. R. D. Kandou periode September–November 2023. Jenis penelitian ialah deskriptif prospektif dengan desain potong lintang, menggunakan data rekam medis Poli Endokrin. Hasil penelitian mendapatkan bahwa pasien DMT2 disertai anemia di RSUP Prof. Dr. R. D. Kandou (n=40), didominasi oleh perempuan (55%) dan kelompok usia 45-60 tahun (62,5%). Rerata nilai HbA1c 8,683, Hb 9,583, kreatinin 3,080, dan eLFG 23,38. Klasifikasi jenis anemia berdasarkan morfologi eritrosit didominasi oleh jenis anemia hipokrom mikrositik yang dialami oleh perempuan (47,5%) dan pada kelompok usia 45-60 tahun (55%). Simpulan penelitian ini ialah mayoritas pasien diabetes melitus tipe 2 disertai anemia terjadi pada perempuan dan kelompok usia 45-60 tahun yang mengalami anemia hipokrom mikrositik.
Kata kunci: diabetes melitus tipe 2; anemia; HbA1c; laju filtrasi glomerulus
References
Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018;14(2):88-98. Doi: 10.1038/nrendo.2017.151
Patoulias D, Papadopoulos C, Stavropoulos K, Zografou I, Doumas M, Karagiannis A. Prognostic value of arterial stiffness measurements in cardiovascular disease, diabetes, and its complications: The potential role of sodium-glucose co-transporter-2 inhibitors. J Clin Hypertens (Greenwich). 2020;22(4):562-71. Doi: 10.1111/jch.13831
Liakopoulos V, Franzén S, Svensson AM, Miftaraj M, Ottosson J, Näslund I, Gudbjörnsdottir S, Eliasson B. Pros and cons of gastric bypass surgery in individuals with obesity and type 2 diabetes: nationwide, matched, observational cohort study. BMJ Open. 2019;9(1):1-9. Doi: 10.1136/bmjopen-2018-023882
IDF Diabetes Atlas. Global diabetes report 2000-2045 (10th ed). 2021. Doi: https://diabetesatlas.org/ idfawp/resource-files/2021/07/IDF_Atlas_10th_Edition_2021.pdf
Kementerian Kesehatan Republik Indonesia. Tetap Produktif, Cegah, dan Atasi Diabetes Melitus. Kemenkes RI; 2020.
Kementerian Kesehatan Republik Indonesia. Hasil Utama RISKESDAS. Kemenkes RI; 2018.
Turner J, Parsi M, Badireddy M. Anemia. StatPearls Publ. 2023. Doi: https://www.ncbi.nlm.nih.gov/ books/NBK499994/
Saxena R. Chamoli S, Batra M. Clinical evaluation of different types of anemia. World Journal of Anemia. 2018;2(1):26-30. Doi: 10.5005/jp-journals-10065-0024
World Health Organization. In: de Benoist B, Mclean E, Egli I, Cogswell M (eds.). Worldwide Prevalence of Anaemia 1993 – 2005. WHO Global Database on Anaemia. Geneva: World Health Organization; 2008 (NLM: WH 155).
Kementerian Kesehatan Republik Indonesia. Profil Kesehatan Indonesia ahun 2017. Kemenkes RI; 2018.
Mohamedahmed KA, Mohammed RM, Talha AA. Anemia and its risk factors among patients with type II diabetes mellitus, Alkhair Medical Center, Wad Medani, Gezira State, Sudan (2020). Int J Health Med Sci. 2022;8(3):13-18. Doi: https://doi.org/10.21203/rs.3.rs-1723846/v2
Farooqi M, Tahir Y, Rehan B. Anemia in patients with type 2 diabetes: a common but neglected clinical finding. Acta Biomed. 2022;93(1):1-2. Doi: 10.23750/abm.v93i1.11204
Barbieri J, Fontela PC, Winkelmann ER, Zimmermann CEP, Sandri YP, Mallet EKV, et al. Anemia in patients with type 2 diabetes mellitus. Hindawi Publishing Corporation. 2015;1(1):1-7. Article ID 354737. Doi: https://doi.org/10.1155/2015/354737
Sukmaningsih WR. Faktor risiko kejadian diabetes melitus tipe II di wilayah kerja puskesmas Purwodiningratan Surakarta [Publikasi Ilmiah]. Surakarta: Universitas Muhammadiyah Surakarta; 2016. Doi: https://eprints.ums.ac.id/42800/1/NASKAH%20PUBLIKASI.pdf
Saraswati PAV, Rena NMRA, Dwipayana IMP, Putra TR. Karakteristik anemia pada penderita diabetes melitus tipe 2 (DMT2) di RSUP Prof. Dr. I.G.N.G. Ngoerah, Bali, Indonesia tahun 2019-2021. Intisari Sains Medis. 2023;14(2):630-634. Doi: https://isainsmedis.id/index.php/ism/article/download/1734/1326
AlDallal SM, Jena N. Prevalence of anemia in type 2 diabetic patients. J Hematol. 2018;7(2):57-61. Doi: 10.14740/jh411w
Alamsyah PR, Andrias DR. Hubungan kecukupan zat gizi dan konsumsi makanan penghambat zat besi dengan kejadian anemia pada lansia. Media Gizi Indonesia. 2019;11(1):48-54. Doi: https://e-journal.unair.ac.id/ MGI/article/view/4389
Prasetya HR, Sistiyono S, Naur MEE. Gambaran anemia pada lanjut usia di panti sosial Tresna Werdha Abiyoso Yogyakarta tahun 2013. Journal of Health. 2014;1(1):23. Doi: https://doi.org/10.30590/vol1-no1-p23-28
Vadila A, Izhar D. Faktor-faktor kejadian diabetes melitus tipe 2 di Puskesmas Putri Ayu. Media Kesehatan Politeknik Kesehatan Makassar. 2021;16(2):229-37. Doi: https://journal.poltekkes-mks.ac.id/ojs2/ index.php/mediakesehatan/article/view/2282/1676
Sherwani SI, Khan HA, Ekhzaimy A, Masood A, Sakharkar MK. Significance of HbA1c test in diagnosis and prognosis of diabetic patients. Biomark Insights. 2016;11:95-104. Doi: 10.4137/BMI.S38440
Yogiswara KS, Herawati S, Wande IN. Gambaran proporsi dan faktor resiko anemia pada pasien diabetes melitus di RSUP Sanglah, Bali, Indonesia. Intisari Sains Medis. 2021;12(1):171-6. Doi: https://doi.org/ 10.15562/ism.v12i1.882
Veronika E, Hartono B. Nilai estimasi glomerulus filtration rate (GFR) menggunakan persamaan Cockcroft and Gault pada masyarakat terpajan merkuri di area pertambangan emas skala kecil (PESK) Desa Lebaksitu Kabupaten Lebak Banten. Forum Ilmiah. 2019;16(2):130-8. Doi: https://ejurnal.esaunggul. ac.id/index.php/Formil/article/view/2810/2393
Ningsih SA, Rusmini H, Purwaningrum R, Zulfian Z. Hubungan kadar kreatinin dengan durasi pengobatan HD pada penderita gagal ginjal kronik. Jurnal Ilmiah Kesehatan Sandi Husada. 2021;10(1):202-7. Doi: https://doi.org/10.35816/jiskh.v10i1.581
Taderegew MM, Gebremariam T, Tareke AA, Woldeamanuel GG. Anemia and its associated factors among type 2 diabetes mellitus patients attending Debre Berhan Referral Hospital, North-East Ethiopia: a cross-sectional study. Journal of Blood Medicine. 2020;11:47-58. Doi: 10.2147/JBM.S243234
Fiseha T, Adamu A, Tesfaye M, Gebreweld A. Prevalence of anemia in diabetic adult outpatients in northeast ethiopia. PLoS One. 2019;14(9):1-12. Doi: https://doi.org/10.1371/journal.pone.0222111
Shariff SA, Akbar N. Hubungan antara status gizi dan pola menstruasi dengan kejadian anemia pada mahasiswi prodi DIII kebidanan universitas muslim indonesia. Window of Health. 2018;1(1):34-35. Doi: https://doi.org/10.33096/woh.v1i1.557
Chaudhry HS, Kasarla MR. Microcytic hypochromic anemia. StatPearls Publ. 2023. Doi: https://www.ncbi. nlm.nih.gov/books/NBK470252/
Yildirim T, Yalcin A, Atmis V, Cengiz OK, Aras S, Varli M, et al. The prevalence of anemia, iron, vitamin B12 and folic acid deficiencies in community dwelling elderly in ankara, turkey. Archives of Gerontology and Geriatrics. 2015;60(2):344-8. Doi: 10.1016/j.archger.2015.01.001
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Gardenia G. E. Rumengan, Bisuk P. Sedli, Linda W. A. Rotty
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
COPYRIGHT
Authors who publish with this journal agree to the following terms:
Authors hold their copyright and grant this journal the privilege of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that permits others to impart the work with an acknowledgment of the work's origin and initial publication by this journal.
Authors can enter into separate or additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (for example, post it to an institutional repository or publish it in a book), with an acknowledgment of its underlying publication in this journal.
Authors are permitted and encouraged to post their work online (for example, in institutional repositories or on their website) as it can lead to productive exchanges, as well as earlier and greater citation of the published work (See The Effect of Open Access).