Analisis Pemberian Propolis terhadap Kadar CA 15-3 Kasus Kanker Payudara Stadium Lanjut

Authors

  • Filandy Pai Universitas Sam Ratulangi
  • Christian Manginstar Universitas Sam Ratulangi
  • Marselus Merung Universitas Sam Ratulangi
  • Fredrik G. Langi Universitas Sam Ratulangi

DOI:

https://doi.org/10.35790/msj.v6i1.48478

Abstract

Abstract: Breast cancer is the first rank of cancer incidence and the second mortality rate in Indonesia. Propolis is already known as a potential anticancer agent. This study aimed to evaluate the effect of propolis administration on CA 15-3 level in breast cancer patients. This was a quasi experimental study with a pre and post test design. Subjects were patients with advanced breast cancer at the Surgery-Oncology polyclinic and Surgery nursing room at Prof. Dr. R. D. Kandou Hospital Manado from June 2022 to March 2023. There were 20 patients with breast cancer in this study, divided into two groups (treatment and control groups) with age and cancer location. Data were analyzed with th independent t-test. The results showed that the increase of CA 15-3 level in treatment group was 8.3±3.5 U/mL meanwhile in the control group was 11.4±3.4 U/mL. There was no significant difference in the increased level of CA 15-3 in the two groups (p=0.069). In conclusion, propolis administration has descriptive effect on breast cancer patients with lower increase of CA 15-3 level compared to the control group, however, there is no significant difference between the two groups.

Keywords: propolis; breast cancer; CA 15-3 marker

 

Abstrak: Kanker payudara menduduki peringkat pertama insidensi kanker dan angka mortalitas kedua di Indonesia. Propolis telah dikenal sebagai agen antikanker yang potensial. Penelitian ini bertujuan untuk mengevaluasi efek pemberian propolis terhadap kadar plasma CA 15-3 penderita kanker payudara. Penelitian ini menggunakan metode kuasi eksperimental pre dan post tes dengan desain potong lintang. Subjek penelitian ialah pasien kanker payudara stadium lanjut di Poliklinik Bedah-Onkologi dan Ruang Perawatan Bedah RSUP Prof. Dr. R. D. Kandou Manado sejak bulan Juni 2022 hingga Maret 2023. Jumlah subjek penelitian sebanyak 20 pasien, dibagi atas dua kelompok (kelompok uji dan kontrol) dengan data demografi usia dan lokasi kanker. Uji satistik yang digunakan ialah uji t tidak berpsangan. Hasil penelitian mendapatkan peningkatan kadar CA 15-3 kelompok uji ialah 8,3±3,5 U/mL sedangkan pada kelompok kontrol sebesar 11,4±3,4 U/mL. Tidak didapatkan perbedaan bermakna untuk kenaikan CA 15-3 pada kelompok uji dan kelompok kontrol (p=0,069). Simpulan penelitian ini ialah pemberian propolis pada pasien kanker payudara stadium lanjut secara deskriptif berefek dengan kadar peningkatan CA 15-3 yang lebih rendah dibandingkan kelompok kontrol tetapi secara statistik tidak terdapat perbedaan bermakna antara kedua kelompok penelitian.

Kata kunci: propolis; kanker payudara; penanda CA 15-3

Author Biographies

Filandy Pai, Universitas Sam Ratulangi

Program Pendidikan Dokter Spesialis Bagian Ilmu Bedah Fakultas Kedokteran Universitas Sam Ratulangi - RSUP Prof. Dr. R. D. Kandou, Manado, Indonesia

Christian Manginstar, Universitas Sam Ratulangi

Divisi Onkologi Bagian Ilmu Bedah Fakultas Kedokteran Universitas Sam Ratulangi - RSUP Prof. Dr. R. D. Kandou, Manado, Indonesia

Marselus Merung, Universitas Sam Ratulangi

Divisi Onkologi Bagian Ilmu Bedah Fakultas Kedokteran Universitas Sam Ratulangi - RSUP Prof. Dr. R. D. Kandou, Manado, Indonesia

Fredrik G. Langi, Universitas Sam Ratulangi

Fakultas Kesehatan Masyarakat Universitas Sam Ratulangi, Manado, Indonesia

References

Ananda SK, Tragoolpua K, Chantawannakul P, Tragoolpua Y. Antioxidant and anticancer cell proliferation of propolis extracts from two extraction methods. Asian Pac J Cancer Prev. 2013; 14(11):6991-5.

Chiu DK, Tse AP, Xu IM, Di Cui J, Lai RK, Li LL, et al. Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma. Nat Commun. 2017;8:517. Doi: 10.1038/s41467-017-00530-7.

Darvishi N, Yousefinejad V, Akbari ME, Abdi M, Moradi N, Darvishi S, et al. Antioxidant and anti-inflammatory effects of oral propolis in patients with breast cancer treated with chemotherapy: a Randomized controlled trial. Journal of Herbal Medicine. 2020;23;100385. Available from: 10.1016/j.hermed.2020.100385.

Davoodi SH, Yousefinejad V, Ghaderi B, Akbari ME, Darvishi S, Mehrabi Y, et al. Oral propolis, nutritional status and quality of life with chemotherapy for breast cancer: a randomized, double-blind clinical trial. Nutr Cancer. 2022;74(6):2029-37. Doi: 10.1080/01635581.2021.1988118.

Eales KL, Hollinshead KE, Tennant DA. Hypoxia and metabolic adaptation of cancer cells. Oncogenesis. 2016;5:e190. Doi: 10.1038/oncsis.2015.50.

Ebeid S, El Moneim NAA, El-Benhawy S,A Hussain N, Hussain M. Assessment of the radioprotective effect of propolis in breast cancer patients undergoing radiotherapy. New perspective for an old honey bee product. Journal of Radiation Research and Applied Sciences. 2016;9(4). Doi: 10.1016/j.jrras.2016.06.001

Kartal M, Yildiz S, Kaya S, Kurucu S, Topcu G. Anti-microbial activity of propolis samples from two different regions of Anatolia. J Ethnopharmacol. 2003;86(1):69-73. Doi: 10.1016/s0378-8741(03)00042-4.

Kaufmann M, Hortobagyi GN, Goldhirsch A, Scholl S, Makris A, Valagussa P, et al. Recommendation from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: an update. J Clin Oncol. 2006;24(12):1940-9. Doi: 10.1200/JCO. 2005.02.6187.

Kubina R, Dzik AK, Dziedzic A, Bielec B, Wojtczka RD, Buldok RJ, et al. The ethanol extract of polish propolis exhibits anti-proliferative and/or pro-apoptotic effect on HCT 116 colon cancer and Me45 malignant melanoma cell in vitro conditions. Adv Clin Exp Med. 2015[24(2):203-12.

Khalil ML. Biological activity of bee propolis in health and disease. Asia Pac J Cancer Prev. 2006;7)1:22-31.

Toi M, Inada K, Hoshina S, Suzuki H, Kondo S, Tominaga T. Vascular endothelial growth factor and platelet-derived endothelial cell growth factor are frequently co-expressed in highly vascularized human breast cancer. Clin Cancer Res. 1995;1:961-4.

Komite Penanggulangan Kanker Nasional. Panduan Penatalaksanaan Kanker Payudara. Jakarta: Kementerian Kesehatan Republik Indonesia; 2018.

Paulino N, Abreu SRL, Machodo G, Silveira E. 2009. Scientific evidences to pharmacological anticancer action of Baccharis dracunculifolia Brazilian propolis. Rev Pesq Inov Farm. 2009;1(1):15-26

Seyhan MF, Yılmaz E, Timirci-Kahraman Ö, Saygılı N, Kısakesen Hİ, Gazioğlu S, et al. Different propolis samples, phenolic content, and breast cancer cell lines: Variable cytotoxicity ranging from ineffective to potent. IUBMB Life. 2019;71(5):619–31.

Vatansever HS, Sorkun K, Gurhan SID, Ozdal-Kurt F, Turkoz E, Gencay O, et al. Propolis from Turkey induces apoptosis through activating caspases in human breast carsinoma cell lines. Acta Histochem. 2010;112(6):546-56. Doi: 10.1016/j.acthis.2009.06.001

Vaupel P, Mayer A, Hockel M. Tumor hypoxia and malignant progression. Methods Enzymol. 2004; 381:335–54. Doi: 10.1016/S0076-6879(04)81023-1

Wagh VD. Propolis: A wonder bees product and its pharmacological potentials. Adv Pharmacol Sci. 2013;2013:308249. doi: 10.1155/2013/308249.

Chang H, Wang Y, Yin X, Liu X, Xuan H. Ethanol extract of propolis and its constituent caffeic acid phenethyl ester inhibit breast cancer cells proliferation in inflammatory microenvironment by inhibiting TLR4 signal pathway and inducing apoptosis and autophagy. BMC Complement Altern Med. 2017;17(1):471. Doi: 10.1186/s12906-017-1984-9.

Xuan H, Li Z, Yan H, Sang Q, Wang K, He Q, et al. Antitumor activity of Chinese propolis in human breast cancer MCF-7 and MDA-MB-231 cells. Evid Based Complement Alternat Med. 2014;2014:280120. Doi: 10.1155/2014/280120.

Downloads

Published

2023-09-13

How to Cite

Pai, F., Manginstar, C., Merung, M., & Langi, F. G. (2023). Analisis Pemberian Propolis terhadap Kadar CA 15-3 Kasus Kanker Payudara Stadium Lanjut. Medical Scope Journal, 6(1), 1–6. https://doi.org/10.35790/msj.v6i1.48478