Liposarcoma of the Thyroid Gland: A Case Report
DOI:
https://doi.org/10.35790/msj.v6i1.51654Abstract
Abstract: Liposarcoma is one of the most common soft tissue tumors in adults. Liposarcoma is usually found in retroperitoneal organs and extremities, but rarely in the thyroid gland. We presented a case of dedifferentiated liposarcoma in the thyroid gland. A 56-year-old woman with a history of a lump in her neck for ten years. Malignancy was suspected due to the local extension of the tumor, therefore, complete resection of the tumor was performed. Histopathological examination showed a dedifferentiated liposarcoma. Two months post-surgery, the patient suffered from lung and brain metastases and was treated with lenvatinib. The complaints reduced and there was no significant side effect during therapy. The treatments for liposarcoma are surgery, radiotherapy, chemotherapy, and targeted therapy. Surgery followed by radiotherapy and chemotherapy is the option in the treatment of liposarcoma. This patient underwent surgery with the histopathological result of dedifferentiated thyroid liposarcoma. In the nine-month follow-up of therapy, there were no complaint of the patient. In this case, dedifferentiated liposarcoma in the thyroid gland with metastases was treated surgically followed by lenvatinib administration gave satisfactory result.
Keyword: liposarcoma; thyroid gland; dedifferentiated liposarcoma; malignant tumor
References
Brose MS, Worden FP, Newbold KL, Guo M, Hurria A. Effect of age on the efficacy and safety of lenvatinib in radioiodine-refractory differentiated thyroid cancer in the phase III SELECT Trial. J Clin Oncol. 2017;35:2692-9.
Cabanillas M, Habra MA. Lenvatinib: Role in thyroid cancer and other solid tumors. Cancer Treatment Reviews. 2016;42:47–55.
Yang L, Chen S, Luo P, Yan W, Wang C. Liposarcoma: Advances in cellular and molecular genetics alterations and corresponding clinical treatment. J Cancer. 2020;11(1):100-7. Doi:10.7150/jca. 36380. Available from: https://www.jcancer.org/v11p0100.htm
Guarda V, Pickhard A, Boxberg M, Specht K, Buchberger AMS. Liposarcoma of the thyroid: a case report with a review of the literature. Eur Thyroid J. 2018;7(2):102-8. Doi: 10.1159/000486333.
Schlumberger M, Tahara M, Wirth LJ, Robinson B, Brose MS, Elisei R, et al. Lenvatinib versus placebo in radioiodine refractory thyroid cancer. N Engl J Med. 2015;372 (7):621-30. Doi: 10.1056/NEJMoa1406470.
Frampton JE. Lenvatinib: A review in refractory thyroid cancer. Target Oncol. 2016;11(1):115-22. Doi: 10.1007/s11523-015-0416-3.
Hamidi S, Boucher A, Lemieux B, Rondeau G, Lebœuf R, Louis-Georges Ste-Marie L-G, et al. Lenvatinib therapy for advanced thyroid cancer: real-life data on safety, efficacy, and some rare side effects. J Endocr Soc. 2022;6(6):bvac048. Doi: 10.1210/jendso/bvac048.
Padda IS, Parmar M. Lenvatinib. National Library of Medicine. StatPearls [Internet]. Available from: https://www/ncbi.nlm.nih.gov/books/NBK567768/
Palla AR, Bollig CA, Jorgensen JB. Well-differentiated liposarcoma localized to the thyroid gland. Eur Thyroid J. 2018;7(5):262-6. Doi: 10.1159/000490346.
Kishimoto Y, Kishimoto AO, Yamada Y, Kitano M, Kitada Y, Kitamura M, Tet al. Dedifferentiated liposarcoma of the thyroid gland: a case report. Mol Clin Oncol. 2019;11(3):219-24. Doi: 10.3892/mco.2019.1882.
Mitra A, Fisher C, Rhys-Evans P, Harmer C. Liposarcoma of the thyroid. Sarcoma. 2004;8:91–6.
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Copyright (c) 2023 Christian Manginstar, Marselus Merung, Denny Saleh, Leise Limpeleh, Enika Tilaar, Ridel Torar
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