EFEK ANTIHIPERGLIKEMIA DARI EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.) YANG DIINDUKSI SUKROSA

Abstract

This study aims to determine the effects of pericarp extracts of mangosteen antihiperglikemia in
wistar strain male mice induced sucrose and compare its effectiveness with glibenclamide. The
method used is a laboratory experiment using a Completely Randomized Design. Subjects in the form
of 15 male white rats tail with weight ranging from 100g-210g are divided into 3 groups of each
group as much as 5 tails. The treatment begins with administration of sucrose solution is adjusted to
the weight of each rat. On the second day evening, the test animals fasted for twelve hours, and the
third day in the morning followed by blood glucose level measured sucrose solution, after thirty
minutes of administration of sucrose solution was measured blood glucose level, the first group were
given distilled water, the second group were given mangosteen rind extract 20%, The third group was
given glibenclamide and 0.3030 mg/g weight had made suspension in 1% CMC solution is then
measured blood sugar test animals one, two, three, and four hours. Data were analyzed with spss
ver.17, the real difference between treatments was tested by one way ANOVA. The results of
statistical analysis gave a significant difference p-value=0.00 (p <0.05) in which the extract can
suppress the KBM 20% increase in KGD in mice and provide similar effectiveness with
glibenclamide.
Key Word : Garcinia mangostana L., Rattus norvegicus L., Sucrose, CMC