UJI EFEK ANTIPIRETIK EKSTRAK ETANOL DAUN PRASMAN (Eupatorium triplinerve Vahl.) PADA TIKUS JANTAN GALUR WISTAR (Rattus Norvegicus L.) YANG DIINDUKSI VAKSIN DTP HB

Authors

  • Stefany Kalay

DOI:

https://doi.org/10.35799/pha.3.2014.5415

Abstract

ABSTRACT
Prasman leaves (Eupatorium triplinerve Vahl.) empirically efficacious as treatment of fever.
This study aims to prove the antipyretic effects of ethanol extract of leaves Prasman against
white male rats Wistar strain vaccines induced DTP HB. This study used 15 male rats were
divided into 5 groups, namely, negative control (CMC), the treatment group (administration
of leaf extracts Prasman 0.03 g/kgBB, 0.06 g/kgBB and 0.12 g/kgBB) and positive control
(Paracetamol). Rat fever induced with vaccine DTP HB intramuscularly 0.08 ml/100 KgBB.
Rectal temperature of mice was measured every 1 hour for 4 hours after oral administration.
The decrease in temperature of mice were analyzed by one-way ANOVA and LSD (α =
0.05%). The results showed that the ethanol extract of the leaves prasman with a dose of 0.03
g/kgBB, 0.06 g/kgBB and 0.12 g/kgBB has an antipyretic effect on white male rats Wistar
strain induced vaccine DTP HB.
Key words : Antipyretics, Eupatorium triplinerve Vahl., vaccine DTP HB
ABSTRAK
Daun Prasman (Eupatorium triplinerve Vahl.) secara empiris berkhasiat sebagai pengobatan
demam. Penelitian ini bertujuan untuk membuktikan efek antipiretik ekstrak etanol daun
Prasman terhadap tikus putih jantan galur wistar yang diinduksi vaksin DTPHB. Penelitian
ini menggunakan 15 ekor tikus jantan dan dibagi menjadi 5 kelompok perlakuan yaitu,
kontrol negatif (CMC), kelompok perlakuan (pemberian ektrak daun Prasman 0,03 g/kgBB,
0,06 g/kgBB dan 0,12 g/kgBB) dan kontrol positif (Parasetamol). Tikus diinduksi demam
dengan vaksin DTP HB dosis 0,08 ml/100 gBB secara intramuskular. Suhu rektal tikus
diukur setiap 1 jam selama 4 jam setelah pemberian per oral. Penurunan suhu tikus dianalisis
dengan uji ANOVA satu arah dan LSD (α = 0,05%). Hasil penelitian menunjukkan bahwa
ekstrak etanol daun prasman dengan dosis 0,03 g/kgBB, 0,06 g/kgBB dan 0,12 g/kgBB
mempunyai efek antipiretik terhadap tikus putih jantan galur wistar yang diinduksi vaksin
DTP HB.
Kata kunci : Antipiretik, Eupatorium triplinerve Vahl., Vaksin DTP HB

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How to Cite

Kalay, S. (2014). UJI EFEK ANTIPIRETIK EKSTRAK ETANOL DAUN PRASMAN (Eupatorium triplinerve Vahl.) PADA TIKUS JANTAN GALUR WISTAR (Rattus Norvegicus L.) YANG DIINDUKSI VAKSIN DTP HB. PHARMACON, 3(3). https://doi.org/10.35799/pha.3.2014.5415

Issue

Vol. 3 No. 3 (2014)

Section

Articles

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